ASPET

DECEMBER 21, 2023

Based on the druggability of DR3penA, we sought to investigate its effects on respirable particulate silicon dioxide (SiO 2 )- and soluble chemical paraquat (PQ)-induced pulmonary fibrosis in this study by using western blot, RT-qPCR, immunofluorescence, H&E and Masson staining, immunohistochemistry and serum biochemical assays.

Biochemical Assays 100

Biochemical Assays Small Molecule Disease Regulations 100

Agency IQ

JUNE 26, 2023

This includes treatments or therapeutics that are intended to serve a specific population that can only be selected (or excluded) via diagnostic guidelines, products for which a diagnostic could identify high-risk patients, and/or those that require monitoring for treatment adjustments. For now, LDTs are filling the gap.

FDA 40

FDA Clinical Trials Laboratories Science 40

Drug Target Review

JANUARY 5, 2024

Å resolution) 6 is now being targeted for small molecule inhibitor discovery and development, by exploiting emergent computational tools to identify potential candidate compounds in silico and then test these predicted inhibitors in in vitro biochemical assays. NIH R01 DA048153 (to D.P.S.), Epub 20230720. doi: 10.1128/jcm.01269-22.

Small Molecule 59

Small Molecule Drugs Biochemical Assays Regulations 59