Chemical Biology and Drug Design

FEBRUARY 3, 2025

An in-house molecule library was screened using in silico molecular docking, and a myo-inositol derivative was identified as a potent hit molecule. The invitro biochemical assays validated that J1-65 inhibits PTP-PEST activity competitively and the inhibitor binding stabilizes the protein-ligand complex.

Small Molecule 100

Small Molecule Biochemical Assays Regulations Drugs 100

Drug Target Review

JULY 12, 2023

Molecular-level biochemical assays like transcriptomics, genomics and proteomics have emerged as valuable tools for identifying potential targets in cancer treatment through deep cyclic inhibition (DCI). Our approach is to treat cancer in fundamentally new ways based on emergent data to optimise therapeutic outcomes.

Biochemical Assays 98

Biochemical Assays Treatment Bioinformatics Disease 98

ASPET

DECEMBER 21, 2023

Our previous research showed that the novel and low-toxicity peptide DR3penA had a strong antifibrotic effect on a bleomycin-induced murine model. The results showed that DR3penA alleviated the extent of fibrosis by inhibiting the expression of fibronectin and collagen I and suppressed oxidative stress and EMT in vitro and in vivo.

Biochemical Assays 100

Biochemical Assays Small Molecule Disease Regulations 100

Drug Target Review

NOVEMBER 1, 2023

Could you provide an overview of your research on target directed cancer drug discovery, particularly your focus on protein lagging interactions. How do structural biology and biochemical methods play a role in your world? We often screen using a biochemical assay, but we can conduct cell-based screening as well.

Fragment Screening 96

Fragment Screening Biochemical Assays Small Molecule Biophysical Assays 96

The Strateos Blog: Drug Discovery

DECEMBER 13, 2021

SLAS 2022 is set to be an exciting conference where scientists can come together to learn about the innovative technologies transforming the way life sciences research is executed. Progress from target ID through to IND submission in conventional workflows can take upwards of 6+ years, where success hinges on iterative cycles of DMTA.

Biochemical Assays 52

Biochemical Assays Small Molecule Laboratories Science 52

PerkinElmer

FEBRUARY 18, 2021

Small screens are better than large ones. Biochemical assays have the highest success rate. Small molecules are making a comeback. These simple, stable compounds, used to treat various conditions, are the focus for 78% of preclinical research. Biologics are booming. Think again.

Biochemical Assays 52

Biochemical Assays Drugs Small Molecule Pharma Companies 52

Molecular Design

DECEMBER 19, 2023

In any case, it needed to be made clear that the quality criteria proposed by the authors for covalently acting small-molecule probes only apply to probes that act irreversibly. Carefully designed biochemical assays used in determining IC50 values can be well-suited as surrogates for k.inact/K.i measurements. (

Small Molecule 65

Small Molecule Biochemical Assays Cell Based Assays Drugs 65