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Biochemical assays and deep cyclic inhibition in cancer treatment

Drug Target Review

Molecular-level biochemical assays like transcriptomics, genomics and proteomics have emerged as valuable tools for identifying potential targets in cancer treatment through deep cyclic inhibition (DCI). Author Bio: Brett Hall Brett has been Chief Scientific Officer at Immuneering since November 2019.

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Target-directed cancer: protein-ligand interactions  

Drug Target Review

We often screen using a biochemical assay, but we can conduct cell-based screening as well. For fragment screening, we can screen with biophysical methods, such as thermal shift assays or, you may have heard about Surface Plasmon Resonance (SPR) which is a very sensitive biophysical technique used for fragment screening.

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Top 10 Drug Discovery Trends at the Top 20 Pharma

PerkinElmer

Biochemical assays have the highest success rate. To lead in product development and partner with customers in solving everyday challenges, we gather information regularly about current practices and future trends,” said Volker Eckelt, PhD, Senior Strategy Leader, PerkinElmer Life Sciences. Biologics are booming. Think again.

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Accelerating Medicinal Chemistry Cycle Times Through Cloud-Accessible Smart Automated Labs - A Preview of Strateos’ Presentation at SLAS 2022

The Strateos Blog: Drug Discovery

SLAS 2022 is set to be an exciting conference where scientists can come together to learn about the innovative technologies transforming the way life sciences research is executed.

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Variability in biological activity measurements reported in the drug discovery literature

Molecular Design

In the Compatibility Issues section the authors state: Looking beyond laboratory-to-laboratory variability of assays that are nominally the same, there are numerous reasons why literature results for different assays measured against the same “target” may not be comparable.

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New gene found plays essential role in stem cell differentiation

Drug Target Review

Researchers from the Bon-Kyoung Koo laboratory at the Institute of Molecular Biotechnology (IMBA) and the Institute for Basic Science have used intestinal organoids to find a new gene, Daam1, that plays an essential role in switching on the development of secretory cells in the intestine. This was published in Science Advances.

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Unique self-activating proteins for drug discovery

Drug Target Review

Å resolution) 6 is now being targeted for small molecule inhibitor discovery and development, by exploiting emergent computational tools to identify potential candidate compounds in silico and then test these predicted inhibitors in in vitro biochemical assays. Thousand Oaks, CA) in 1999 before returning to academia. fowleri. (