Drug Target Review
NOVEMBER 1, 2023
For fragment screening, which are much smaller compounds, we have a library of about 3000 fragments. We can screen with many different formats and modalities. We often screen using a biochemical assay, but we can conduct cell-based screening as well.
Practical Cheminformatics
AUGUST 3, 2023
It is quite a bit more potent than the values one finds with screening hits, which typically have IC50s in the single to double-digit µM range. Initially, I would recommend aqueous solubility, membrane permeability, in vitro metabolic stability, and biochemical assays. 200nM is an odd choice for an activity cutoff.
Expert insights. Personalized for you.
96 
Let's personalize your content