Biochemical Pharmacology and Regulations

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Biochemical Pharmacology

Regulations

Bile acids and the microbiome: revolutionising disease approaches

Drug Target Review

MARCH 12, 2024

Bile acids are crucial signalling molecules that aid the regulation of the immune system and have essential metabolic functions, like controlling lipid and glucose metabolism. Biochemical Pharmacology. Also, they help to explain how microbes in the gut can influence distant organ systems. Gut Microbes.

Disease

Disease Biochemical Pharmacology FDA Approval Pharmacy

Targeting the immunotherapy potential of cytokines IL-12 and IL-18 with new advancements in protein engineering

Drug Target Review

JUNE 6, 2023

This suppressive mechanism involves a negative regulator – a protein called IL-18BP or IL-18 binding protein, that works as a “decoy receptor” by binding to IL-18 and preventing it from binding to its functional receptor. Clinical development of IL-18 therapies has been curtailed, however, by the protein’s lack of efficacy.

Engineering

Engineering Immune Response Biochemical Pharmacology Clinical Trials

Drug Discovery Digest

Bile acids and the microbiome: revolutionising disease approaches

Targeting the immunotherapy potential of cytokines IL-12 and IL-18 with new advancements in protein engineering

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