The Open Targets Blog

OCTOBER 31, 2023

This blog post is part of a series that will explore applications and expansions of the Open Targets informatics ecosystem, particularly the Open Targets Platform and Open Targets Genetics through conversations with our users. Open Targets delivers easy-to-navigate aggregated information and evidence linking therapies, genes, and diseases.

Bioinformatics 67

Bioinformatics Engineering Clinical Trials Therapies 67

The Premier Consulting Blog

JUNE 18, 2023

One exciting application of these technologies is the use of in silico trials in the development of novel therapies for rare diseases. As a direct consequence, in silico methods in human clinical trials are emerging as an important new paradigm in the development of medical therapies – particularly useful for rare diseases.

Drug Development 52

Drug Development Disease Clinical Trials Drugs 52

Codon

MAY 15, 2023

This paper paves the way for off-the-shelf cell therapies that don’t require immunosuppressive drugs. link ) Administering multiple doses of lentiviral vectors (used for gene therapy) into mouse lungs is better for long-term gene expression than a single dose. Gene Therapy. Bioinformatics. Bioinformatics.

DNA 52

DNA Bioinformatics Engineering Virus 52

Codon

MAY 15, 2023

This paper paves the way for off-the-shelf cell therapies that don’t require immunosuppressive drugs. link ) Administering multiple doses of lentiviral vectors (used for gene therapy) into mouse lungs is better for long-term gene expression than a single dose. Gene Therapy. Bioinformatics. Bioinformatics.

DNA 52

DNA Bioinformatics Engineering Virus 52

Crown Bioscience

JANUARY 23, 2025

The integration of data science and bioinformatics has become a cornerstone of modern oncology drug discovery. Through data-driven approaches, researchers are now able to make better, more informed decisions, uncover hidden patterns in cancer biology, and streamline the development of life-saving therapies.

Bioinformatics 52

Bioinformatics Science Drugs Therapies 52

Codon

APRIL 16, 2023

Compact gene editors , called enOsCas12f1 and enRhCas12f1, are smaller than many existing Cas proteins and can thus be more easily delivered in a single virus for gene therapies. BMC Bioinformatics. Read Development of a translatable gene augmentation therapy for CNGB1-Retinitis Pigmentosa. Molecular Therapy. Occelli L.M.

Engineering 52

Engineering DNA RNA Science 52

Codon

AUGUST 10, 2023

Link ( See the blog by Mohammed AlQuraishi.) Link (See this blog about the synthetic yeast project.) Link The coming of age of de novo protein design , by Huang P-S. Nature (2016). Link Highly accurate protein structure prediction with AlphaFold , by Jumper J. Nature (2021). Genome Synthesis →Synthetic Genomes , by Zhang W.

DNA 98

DNA Cell Biology Molecular Biology Engineering 98