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In a new development, a recent paper published in Biology Methods & Protocols by Oxford University Press has highlighted a promising avenue for enhancing vaccine efficacy against infectious pathogens like the COVID-19 virus. The implications of this finding are far-reaching, as it holds the potential to revolutionize vaccine design.
In 2015, Methuselah Health was founded to investigate the role of proteome instability during ageing, and the extent to which the instability of specific proteins might underlie development of age-related diseases – a concept that arose from the ground-breaking work of Professor Miro Radman (which DrugBaron highlighted previously).
One exciting application of these technologies is the use of in silico trials in the development of novel therapies for rare diseases. However, with rare diseases there may be no available treatments that could serve as SoC or active control in a clinical trial and assigning patients to placebo may be unethical.
At the Broad, he directs the Cancer Genome Computational Analysis Group , and he is a professor of pathology at Harvard Medical School and director of bioinformatics at Massachusetts General Hospital. Anna Greka ’s research focuses on fundamental mechanisms of cellular dysfunction in genetic diseases with a focus on membrane proteins.
is its relation to the disease well figured out and validated? Dr Ofran received a PhD with distinction in Molecular Biophysics and Biomedical Informatics from Columbia University and was a professor of bioinformatics and molecular research at Bar-Ilan University. Is there still an unmet need? Can our technology solve the problem?
Recent advances in bioinformatics show clonal neoantigens are the best targets for immunotherapy, as I will elucidate below. Patients with high numbers of clonal neoantigens show improved disease-free survival. These mutations are called clonal mutations or clonal neoantigens.
Joneckis said that CBER has “some limited uses that we have seen in external submissions, mostly in the bioinformatics area,” but not as many as CDER. Regarding artificial intelligence (AI), an important topic at RAPS Convergence, the two centers discussed external and internal use cases.
Doctors in training are told that when they hear hoofbeats, they should think horses, not zebras; rare diseases are the exception, not the rule. Sometimes, though, novel diseases do emerge, and as COVID-19 demonstrated, they can surprise us. New Yorkers wait to receive a monkeypox vaccine.
Cancer is a disease driven by variable genetic mutations. N17350 has induced this immune effect in every preclinical model tested, suggesting that its therapeutic efficacy involves direct cancer-cell killing, leading to vaccine-like properties.
Early targets may include sickle-cell disease, Friedrich’s ataxia, and cystic fibrosis. link ) A phase I trial of a personalized neoantigen vaccine showed that they could boost T-cells and help fight off pancreatic tumors. Bioinformatics. Bioinformatics. Nature Communications. Nucleic Acids Research.
Early targets may include sickle-cell disease, Friedrich’s ataxia, and cystic fibrosis. link ) A phase I trial of a personalized neoantigen vaccine showed that they could boost T-cells and help fight off pancreatic tumors. Bioinformatics. Bioinformatics. Nature Communications. Nucleic Acids Research.
These factors are converging to enable both identification of novel infectious diseases as well as microbial resistance, before these threats can impact public health, write a team from the European Society for Clinical Microbiology and Infectious Diseases in Frontiers in Science. Work on vaccines ensued too.
WHO launches global network to detect and prevent infectious disease threats WHO and partners are launching a global network to help protect people from infectious disease threats through the power of pathogen genomics. Diseases do not respect borders: a disease threat in one country is also a threat to others.
When our backs were against the wall, the biotech/biopharma community came together to create not one, but two vaccines currently approved for emergency use in the U.S. Maybe we need to treat the host rather than the cell or the disease. This has earned the industry a lot of respect. Maybe we need to modulate the host.”.
BMC Bioinformatics. Read The T-cell-directed vaccine BNT162b4 encoding conserved non-spike antigens protects animals from severe SARS-CoV-2 infection. Read Effectiveness of a bivalent mRNA vaccine booster dose to prevent severe COVID-19 outcomes: a retrospective cohort study. The Lancet Infectious Diseases. Arieta C.M.
A concerned employee at a laboratory supply company had called the Centers for Disease Control, or CDC, after fielding repeated calls from Harris asking when his samples of plague would arrive in the mail. 5 But it could match up to one of the threats in your reference database, so you opt to throw a battery of bioinformatics tools at it.
“Alongside our industry-leading collaborators, we are investigating novel endpoints, brain volume and cognition, which may help to further our understanding of the safety and efficacy profile of Zeposia and can advance transformational science for multiple sclerosis patients experiencing this unpredictable, debilitating disease.”.
Drug Discovery Today: Disease Models (2008). Craig Venter Higher Animals: Vaccines, Synthetic Biology, and the Future of Life , by Michael Specter What’s Your Bio Strategy? , Link Artificial Gene Regulatory Networks—A Review , by Cussat-Blanc S. Artificial Life (2018).
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