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Advancing vaccine design: potential of peptide mimicry

Drug Target Review

In a new development, a recent paper published in Biology Methods & Protocols by Oxford University Press has highlighted a promising avenue for enhancing vaccine efficacy against infectious pathogens like the COVID-19 virus. The implications of this finding are far-reaching, as it holds the potential to revolutionize vaccine design.

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A quiet revolution in the world of proteomics

DrugBaron

In 2015, Methuselah Health was founded to investigate the role of proteome instability during ageing, and the extent to which the instability of specific proteins might underlie development of age-related diseases – a concept that arose from the ground-breaking work of Professor Miro Radman (which DrugBaron highlighted previously).

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In Silico Modeling Unveils a New Era in Rare Disease Drug Development

The Premier Consulting Blog

One exciting application of these technologies is the use of in silico trials in the development of novel therapies for rare diseases. However, with rare diseases there may be no available treatments that could serve as SoC or active control in a clinical trial and assigning patients to placebo may be unethical.

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Six scientists named as new core institute members at Broad

Broad Institute

At the Broad, he directs the Cancer Genome Computational Analysis Group , and he is a professor of pathology at Harvard Medical School and director of bioinformatics at Massachusetts General Hospital. Anna Greka ’s research focuses on fundamental mechanisms of cellular dysfunction in genetic diseases with a focus on membrane proteins.

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Unlocking the potential of smart antibodies

Drug Target Review

is its relation to the disease well figured out and validated? Dr Ofran received a PhD with distinction in Molecular Biophysics and Biomedical Informatics from Columbia University and was a professor of bioinformatics and molecular research at Bar-Ilan University. Is there still an unmet need? Can our technology solve the problem?

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Not all neoantigens are created equal

Drug Target Review

Recent advances in bioinformatics show clonal neoantigens are the best targets for immunotherapy, as I will elucidate below. Patients with high numbers of clonal neoantigens show improved disease-free survival. These mutations are called clonal mutations or clonal neoantigens.

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Article FDA Thank You Leaders at FDA share highlights and updates for drugs and biologics at RAPS Convergence

Agency IQ

Joneckis said that CBER has “some limited uses that we have seen in external submissions, mostly in the bioinformatics area,” but not as many as CDER. Regarding artificial intelligence (AI), an important topic at RAPS Convergence, the two centers discussed external and internal use cases.

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