Broad Institute

AUGUST 4, 2022

To build the CLL map, the team analyzed variations in genetic sequences, gene expression patterns, and chemical modifications to DNA — or genomic, transcriptomic, and epigenomic data — from 1,148 patients.

Bioinformatics 52

Bioinformatics Medical Schools Hospitals Treatment 52

The Pharma Data

JANUARY 24, 2021

Diversigen provides consultative end-to-end solutions for sequencing, bioinformatics, and statistical analysis for the study of the microbiome of living organisms and environments. Diversigen, Inc. OraSure Technologies empowers the global community to improve health and wellness by providing access to accurate, essential information.

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The Pharma Data

NOVEMBER 23, 2020

“Environmental sensitivity and corporate responsibility have been part of our DNA since our inception,” said Martine Rothblatt , Ph.D., SILVER SPRING, Md. and RESEARCH TRIANGLE PARK, N.C. , Chairman and Chief Executive Officer of United Therapeutics.

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Vial

DECEMBER 5, 2023

Transforming Genomics Research Next-generation sequencing (NGS) enables comprehensive genome sequencing and has transformed genomics research, offering vastly improved capabilities for analyzing DNA and RNA in a high-throughput and cost-effective manner. Satam et al.

Clinical Trials 52

Clinical Trials Trials RNA Bioinformatics 52

The Open Targets Blog

APRIL 25, 2023

via Wikimedia Commons) Right: Copy of a DNA sequence faxed in 1989 from teams working on the Human Genome Project (from the Wellcome Collection archives, Image credit: Helena Cornu)  Assembling a team At the core of this of course were people to provide both the intellectual input and the perseverance to make things happen. Searls, D.B.

DNA 52

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DrugBaron

NOVEMBER 22, 2022

It incorporates a number of different technological advances both in the practical LC-MS data collection and in the subsequent bioinformatic analysis developed by Methuselah Health over the last decade. A wide range of proprietary bioinformatic tools are then used to extract knowledge from these ultra-large, ultra-accurate datasets.

Bioinformatics 100

Bioinformatics Regulations Molecular Biology Engineering 100

Drug Target Review

JULY 24, 2023

The first identification was based on a bioinformatic analysis. Other than essential cellular processes are likely occurring in the apicoplast compartment. How did the researchers identify a nuclear-encoded apicoplast RNA polymerase σ subunit in the study?

RNA 98

RNA Regulations Bioinformatics Laboratories 98

Broad Institute

AUGUST 11, 2022

It’s been very exciting to integrate genetics, bioinformatics, biochemistry, and structural biology approaches in one study to understand this fascinating molecular system.” Most known bacterial defense systems work by sensing viral DNA or RNA, or cellular stress due to the infection. The finding was striking and unprecedented.

DNA 52

DNA Virus Immune Response Bioinformatics 52

Drug Target Review

DECEMBER 28, 2023

During the process of transformation from a normal cell into a cancer cell, a cell acquires a series of changes, or mutations, in its DNA. But DNA mutations can also result in changes to the proteins that are displayed on the surface of the cancer cell. These mutations are called clonal mutations or clonal neoantigens.

Bioinformatics 105

Bioinformatics Immune Response DNA Vaccine 105

Codon

AUGUST 27, 2024

Allison Berke makes the case for real-time DNA sequencing and AI tools to detect pathogens before they spread widely. Reading DNA The first step in detecting a novel pathogen is recognizing it as an anomaly amidst a noisy background of other material. After copying the DNA to form a big pool, each piece is sequenced.

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DNA Laboratories Hospitals Virus 99

Codon

MAY 15, 2023

3/ Prime Editing Spree Prime editors can change DNA in ways that Cas9 — and even base editors — cannot. Known as a "search-and-replace" gene-editing tool, prime editors can delete or replace DNA up to 10,000 bases in length, or substitute one base for another. Read more in Cell. ( #1 , #2 ) (Video credit: Gong Y.

DNA 52

DNA Bioinformatics Engineering Virus 52

Codon

MAY 15, 2023

3/ Prime Editing Spree Prime editors can change DNA in ways that Cas9 — and even base editors — cannot. Known as a "search-and-replace" gene-editing tool, prime editors can delete or replace DNA up to 10,000 bases in length, or substitute one base for another. Read more in Cell. ( #1 , #2 ) (Video credit: Gong Y.

DNA 52

DNA Bioinformatics Engineering Virus 52

PLOS: DNA Science

MAY 16, 2024

Many of the links below are to some of the 100+ DNA Science posts that I wrote during the pandemic. Other genomic databases were retooled for the huge datasets that COVID was generating, such as the Cloud Institute for Microbial Bioinformatics, begun in 2014 and rechristened the COVID-19 Genomics UK Consortium ( COG-UK ).

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The Pharma Data

MARCH 20, 2021

Bioinformatics in the Faculty. DNA biomarker services in an accredited environment. Vandesompele is a research. professor in Functional Cancer Genomics and Applied. of Medicine and Health Sciences (Ghent University) and. also the co-founder and CSO of. Biogazelle, an innovative bioanalytical services company offering RNA and.

Laboratories 52

Laboratories Virus RNA Bioinformatics 52

Codon

APRIL 16, 2023

Short DNA strands were discovered that can specifically and tightly bind to zinc and cadmium ions. Perhaps there is now a way to use DNA to extract metals: You could fuse the DNA strands to an antibody, coat them onto electronics, and then use a column to isolate the DNA:metal compounds? BMC Bioinformatics. Mansilla S.F.

Engineering 52

Engineering DNA RNA Science 52

Codon

AUGUST 28, 2024

Tessa Alexanian and Max Langenkamp build computational DNA screening tools for a living. But today, rapid advances in DNA synthesis have made it possible for would-be bioterrorists to make pathogens, rather than buy them. government must order synthetic DNA from providers who publicly state that they follow the U.S.

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DNA Bioinformatics Virus Government 92

The Pharma Data

JANUARY 10, 2021

I actually think neuroscience is going to heat up in 2021,” said Ben Zeskind , co-founder and CEO of Immuneering , which is using bioinformatics and computational biology to develop new drugs in this space, along with oncology and immuno-oncology. Moving on From the Amyloid Hypothesis. “I

Vaccine 52

Vaccine Disease Regulations Small Molecule 52

Codon

AUGUST 10, 2023

Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link Next-Generation DNA Sequencing Methods , by Mardis E.R. Link DNA synthesis technologies to close the gene writing gap , by Hoose et al.

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DNA Cell Biology Molecular Biology Engineering 98

Conversations in Drug Development Trends

APRIL 7, 2025

Liquid biopsies, particularly those that detect circulating tumor DNA amongst other known blood-based biomarkers, make the screening process less invasive and more approachable to patients who already undergo multiple blood draws daily, reducing participation burden.

Research 40

Research Clinical Trials Trials Clinical Research 40

Codon

AUGUST 10, 2023

Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link Next-Generation DNA Sequencing Methods , by Mardis E.R. Link DNA synthesis technologies to close the gene writing gap , by Hoose et al.

DNA 52

DNA Cell Biology Engineering Molecular Biology 52