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Not all neoantigens are created equal

Drug Target Review

During the process of transformation from a normal cell into a cancer cell, a cell acquires a series of changes, or mutations, in its DNA. But DNA mutations can also result in changes to the proteins that are displayed on the surface of the cancer cell. These mutations are called clonal mutations or clonal neoantigens.

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Can Global Genomic Surveillance Forecast the Next Pandemic?

PLOS: DNA Science

Many of the links below are to some of the 100+ DNA Science posts that I wrote during the pandemic. Other genomic databases were retooled for the huge datasets that COVID was generating, such as the Cloud Institute for Microbial Bioinformatics, begun in 2014 and rechristened the COVID-19 Genomics UK Consortium ( COG-UK ).

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Twist Bioscience Harnesses AI-Powered Cloud for Synthetic Biology Breakthroughs

Fierce BioTech

The company has developed a disruptive DNA synthesis platform that pioneers a new method of manufacturing synthetic DNA by “writing” DNA on a silicon chip. Listing Image oracle Listing Introduction Twist Bioscience’s DNA-based products are powering research to improve the lives of millions of people. Click here to login.

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Defense-Forward Biosecurity

Codon

Allison Berke makes the case for real-time DNA sequencing and AI tools to detect pathogens before they spread widely. Reading DNA The first step in detecting a novel pathogen is recognizing it as an anomaly amidst a noisy background of other material. After copying the DNA to form a big pool, each piece is sequenced.

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Malaria unravelled: decoding the parasite’s gene expression control

Drug Target Review

The first identification was based on a bioinformatic analysis. Other than essential cellular processes are likely occurring in the apicoplast compartment. How did the researchers identify a nuclear-encoded apicoplast RNA polymerase σ subunit in the study?

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Kickstarting the use of AI for biotechs: part two

Drug Target Review

2 AlphaFold 3 has been built to model DNA, RNA and smaller molecules (ligands). 5 Several major technology areas are not included above, such as cheminformatics and bioinformatics. Google DeepMind’s new AI can model DNA, RNA, and ‘all life’s molecules’. The latest exciting advancement is AlphaFold 3, which was just released.

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Boehringer Ingelheim and Twist Bioscience Enter Therapeutic Antibody Discovery Collaboration

The Pharma Data

By leveraging our unique ability to manufacture DNA at scale, we can construct proprietary antibody libraries precisely designed to match sequences that occur in the human body. The core of the platform is a proprietary technology that pioneers a new method of manufacturing synthetic DNA by “writing” DNA on a silicon chip.

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