Drug Discovery World

APRIL 18, 2023

DDW’s Megan Thomas rounds up highlights from Tuesday 17 April at AACR 2023, from AI and mathematical oncology to winners of the AACR James S Ewing-Thelma B Dunn Award for Outstanding Achievement in Pathology in Cancer Research. Dunn Award for Outstanding Achievement in Pathology in Cancer Research Another award highlight was the AACR James S.

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Fierce BioTech

OCTOBER 26, 2023

The company has developed a disruptive DNA synthesis platform that pioneers a new method of manufacturing synthetic DNA by “writing” DNA on a silicon chip. Listing Image oracle Listing Introduction Twist Bioscience’s DNA-based products are powering research to improve the lives of millions of people.

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Drug Discovery World

NOVEMBER 7, 2022

A new study led by Medical Research Council-funded researchers from UCL has found that tailoring the analysis of whole genome sequencing to individual patients could double the diagnostic rates of rare diseases. . Context . The study . It also detected potential disease-causing variants in a further 3.9% of patients. .

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Drug Discovery World

SEPTEMBER 9, 2024

This capability enables their use in various bioinformatics and cheminformatics applications, including predicting DNA regulatory elements and optimising drug properties. By providing researchers with valuable insights, AI can help develop drugs targeting complex and hard-to-treat diseases.

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Codon

AUGUST 28, 2024

Tessa Alexanian and Max Langenkamp build computational DNA screening tools for a living. When the CDC contacted Harris to ask about the plague samples, Harris claimed that he was doing research for the CIA to stop an “imminent invasion from Iraq of super-germ-carrying rats.” This article concludes our mini-issue.

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Drug Target Review

MAY 24, 2024

2 AlphaFold 3 has been built to model DNA, RNA and smaller molecules (ligands). 5 Several major technology areas are not included above, such as cheminformatics and bioinformatics. Google DeepMind’s new AI can model DNA, RNA, and ‘all life’s molecules’. The latest exciting advancement is AlphaFold 3, which was just released.

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Drug Target Review

JULY 24, 2023

Researchers from Tokyo Tech’s World Research Hub Initiative conducted a study to investigate the regulation of gene expression in the apicoplast of the malaria parasite Plasmodium falciparum. He has shared his excitement about the study’s implications and how it opens up new avenues in malaria research.

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The Pharma Data

JANUARY 24, 2021

His research focuses on the role of the microbiome in immune defense and disease resistance. “We Diversigen provides consultative end-to-end solutions for sequencing, bioinformatics, and statistical analysis for the study of the microbiome of living organisms and environments. (NASDAQ: OSUR), today announced that Eric Pamer, M.D.,

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The Pharma Data

SEPTEMBER 11, 2021

Senior Corporate Vice President and Global Head of Discovery Research at Boehringer Ingelheim. “We Twist and Boehringer Ingelheim will work together to validate and optimize any resulting new antibody candidates, which could be researched against a range of therapeutic areas. Wood, Ph.D., Leproust, Ph.D., CEO and co-founder of Twist.

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Drug Discovery World

JULY 11, 2023

Now, with the growth of publicly available genomics, transcriptomics, and proteomics databases, the ability to quickly carry out large-scale DNA, RNA, and protein screenings, and the availability of massive sets of de-identified patient data, the amount of high-value, analysable data has reached enormous proportions.

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Drug Discovery World

APRIL 14, 2023

The American Association for Cancer Research (AACR) will honour the following cancer researchers, physician-scientists, advocates, and journalists during its annual meeting to be held April 14-19 at the Orange County Convention Center in Orlando, Florida. June’s award lecture will be held on Sunday April 16 at 4:30pm ET.

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Drug Discovery World

JULY 26, 2023

An industry overview of the role of the microbiome in precision medicine, and its interplay with research tools, diagnostics, and therapeutic development. Research increasingly demonstrates that within each discrete microbial environment (e.g., Research increasingly demonstrates that within each discrete microbial environment (e.g.,

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The Pharma Data

NOVEMBER 23, 2020

and RESEARCH TRIANGLE PARK, N.C. , “Environmental sensitivity and corporate responsibility have been part of our DNA since our inception,” said Martine Rothblatt , Ph.D., and RESEARCH TRIANGLE PARK, N.C. , Report available at corporateresponsibility.unither.com. SILVER SPRING, Md. SILVER SPRING, Md.

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Drug Discovery World

OCTOBER 25, 2023

DDW Editor Reece Armstrong speaks to Dr Darrell Green , Lecturer in RNA Biology Biomedical Research Centre Norwich Medical School University of East Anglia, about his work using next generation sequencing (NGS) and the areas the technology is impacting within drug discovery and development.

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Drug Discovery World

NOVEMBER 15, 2022

Rapid and accurate DNA synthesis . Conventional DNA synthesis, typically used for making sequences such as primers, employs phosphoramidite chemistry, a method that was developed in the 1980s and is still considered the gold standard for DNA synthesis. .

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Codon

AUGUST 27, 2024

Allison Berke makes the case for real-time DNA sequencing and AI tools to detect pathogens before they spread widely. Reading DNA The first step in detecting a novel pathogen is recognizing it as an anomaly amidst a noisy background of other material. After copying the DNA to form a big pool, each piece is sequenced.

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Drug Discovery World

JULY 29, 2022

Scientists from seven research institutions including the University of Oxford and the University of Edinburgh have used pioneering bioinformatic modelling to investigate the molecular interactions of the p53 protein known to give protection against cancers.

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Drug Discovery World

APRIL 29, 2024

Bill Dawson, Chair, Medicines Manufacturing Industry Partnership (MMIP): Dawson is Head of Biologics and Devices Manufacturing at GSK and has over 25 years’ experience in the vaccines, biopharma, pharmaceutical and clinical research (CRO) industries. He has a PhD in Bioinformatics from the University of Cambridge.

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Elrig

APRIL 29, 2024

With a background in Bioinformatics and Computational Biology, she has a keen interest in using technology to solve problems in healthcare and medicine. Miguel Gancedo Rodrigo Miguel Gancedo Rodrigo Research Investigator, Isomorphic Labs My name is Miguel, and I’m from Murcia, Spain.

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Broad Institute

AUGUST 11, 2022

A team led by researchers at the Broad Institute of MIT and Harvard and the McGovern Institute for Brain Research at MIT has discovered and characterized one of these unexplored microbial defense systems. In the new study, the researchers wanted to know if the proteins work the same way in prokaryotes to defend against infection.

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Drug Discovery World

APRIL 14, 2023

At the beginning of 2023, proteomics company Nautilus Biotechnology announced a partnership with the Translational Genomics Research Institute (TGen), to study the specific proteins at work in the rare and often fatal childhood cancer, diffuse intrinsic pontine glioma (DIPG).

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Drug Discovery World

SEPTEMBER 7, 2022

Many companies have embarked on a digitalisation journey, convinced that their notebook entries, DNA and protein designs, samples used in experiments, and experimental conditions should all be tracked and stored in software. If all the work scientists do is captured in software, it ought to be easier to analyse. .

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Drug Discovery World

NOVEMBER 9, 2023

Novel platforms This session will begin with chariperson’s remarks from Lars Linden, PhD, Vice President, Head, Biologics Research, Bayer HealthCare, which will be followed by a keynote presentation by Agnieszka Kielczewska, PhD, Director, Research, Antibody Discovery and Screening, Biologics Discovery, Amgen.

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Drug Discovery World

NOVEMBER 13, 2023

Thereafter, the following presentations will take place: Melody Shahsavarian, PhD, Digital Biologics Platform, Large Molecules Research, Sanofi, on: ‘Enhancing antibody discovery with generative AI’. Ali Madani, PhD, Founder and CEO, Profluent Bio, on: ‘Protein engineering with large language models’.

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Codon

MAY 15, 2023

🔥 Week in Review Biotech research highlights in under 5 minutes. For one of the studies , researchers collected blastocysts from cynomolgus monkeys, the long-tailed macaques native to southeast Asia. 3/ Prime Editing Spree Prime editors can change DNA in ways that Cas9 — and even base editors — cannot.

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Codon

MAY 15, 2023

🔥 Week in Review Biotech research highlights in under 5 minutes. For one of the studies , researchers collected blastocysts from cynomolgus monkeys, the long-tailed macaques native to southeast Asia. 3/ Prime Editing Spree Prime editors can change DNA in ways that Cas9 — and even base editors — cannot.

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Broad Institute

JULY 10, 2023

Thanks in part to her research, more geneticists are now studying a wider diversity of people and accounting for genetic ancestry in their analyses. Through this work, Martin is showing how a methodical, data-driven kind of social justice can help improve equity in scientific research and lead to better science.

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Drug Discovery World

NOVEMBER 30, 2023

Panel moderators included Ulf Grawunder from T-CURX and Astero Klampatsa from the Insitute of Cancer Research, and panellists included John Anderson from University College London, Michael Hudecek from University of Applied Sciences Wuerzburg-Schweinfurt, as well as Sebastian Kobold from Klinikum de Universität München.

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BMG Labtech

OCTOBER 4, 2023

These numbers reflect impressive developments in DNA sequencing technologies but in most cases represent the immediate costs of consumables on the sequencing instrument. 2 DNA sequencing is also reliant on sample processing and DNA library preparation before sequencing as well as bioinformatics and data analysis after sequencing.

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Vial

DECEMBER 5, 2023

Next-generation sequencing (NGS) has revolutionized scientific research and clinical genomics due to high-throughput multiplexing and shed light on genome structure, function, and dynamics. It has become a fundamental tool for researchers to explore the complexities of genetic information and conduct genetic-informed drug development.

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Dark Matter Blog

AUGUST 31, 2020

However, since most small molecule drugs target proteins in the cell, the vast majority of target identification methods available to research scientists are aimed at identifying interactions between small molecules and proteins. With millions of DNA sequences, we could precisely measure the rate of RT pausing at each position of the RNA.

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Broad Institute

AUGUST 4, 2022

To build the CLL map, the team analyzed variations in genetic sequences, gene expression patterns, and chemical modifications to DNA — or genomic, transcriptomic, and epigenomic data — from 1,148 patients. This work was supported by the National Institutes of Health and the Broad/IBM Cancer Resistance Research Project.

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The Anticancer Fund

MARCH 24, 2023

Our intention is to help bring these findings to the attention of the broader cancer research community. All articles need to be critically assessed and viewed in their broader research context. Please get in touch if you’re interested in discussing research based on the findings presented below ( info@anticancerfund.org ).

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DrugBaron

NOVEMBER 22, 2022

To enable that research, the team at Methuselah Health needed a proteomics approach that would accurately quantify post-translational modifications across the proteome – and since that didn’t exist, their Chief Technology Officer, David Mosedale, set about creating it.

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The Pharma Data

MARCH 20, 2021

Medicine in Oxford, Biogazelle, a biotechnology company in Ghent, and the Centre For Proteome Research at the University of Liverpool. Vandesompele is a research. Bioinformatics in the Faculty. DNA biomarker services in an accredited environment. the Emmott Lab in the Centre for Proteome Research at Liverpool University.

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The Pharma Data

JANUARY 10, 2021

I actually think neuroscience is going to heat up in 2021,” said Ben Zeskind , co-founder and CEO of Immuneering , which is using bioinformatics and computational biology to develop new drugs in this space, along with oncology and immuno-oncology. In a boone for Slonim’s research focus, the year 2020 has made this molecule a household name.

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Codon

AUGUST 10, 2023

Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Nucleic Acids Research (2010).

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