Broad Institute

AUGUST 29, 2016

Software Engineering Broad scientists generate 24TB of raw genomic sequence data every day. Computational Biology Broad computational biologists and bioinformatics analysts collaborate with interdisciplinary teams of scientists who are working together to revolutionize the way biomedical research is done.

Bioinformatics 52

Bioinformatics Engineering Science Research 52

DrugBaron

NOVEMBER 22, 2022

For example, thrombin is generated by the cleavage of prothrombin by the prothrombinase complex; C3b the “engine” of the complement response is generated by the cleavage of C3 by enzymes such as complement factor B. Yet most modern proteomic protocols cannot readily distinguish thrombin from prothrombin or C3b from C3.

Bioinformatics 100

Bioinformatics Regulations Molecular Biology Engineering 100

Elrig

APRIL 29, 2024

With a background in Bioinformatics and Computational Biology, she has a keen interest in using technology to solve problems in healthcare and medicine. Bioinformatics is all about bringing together different areas of knowledge. Do you think the current talent pool supply meets the demand?

Bioinformatics 59

Bioinformatics Drugs Molecular Biology Cell Based Assays 59

Broad Institute

SEPTEMBER 30, 2024

As it turned out, software engineering teams at the Broad Institute had already created a solution — Terra , an open, secure, and collaborative environment created in a collaboration between Broad, Verily, and Microsoft, where users can analyze and share biomedical and public health data.

Bioinformatics 101

Bioinformatics Disease Engineering Virus 101

The Pharma Data

NOVEMBER 25, 2020

Egle has leveraged its unique bioinformatic and translational capabilities to successfully identify targets that will now be pursued under the terms of the alliance. Upon achievement of the target identification, Egle will receive an R&D milestone payment and investment from Takeda.

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Research Bioinformatics Pharmaceutical Companies Engineering 52

The Pharma Data

MARCH 20, 2021

In connection with research programs covering yeast fermentation, fungal fermentation, lactic acid fermentation, bio catalysis and genomic tools including bioinformatics, the center is always on the lookout for the latest developments in inline measurement technology. Scope of possible application .

Bioinformatics 52

Bioinformatics Laboratories Production Engineering 52

Practical Cheminformatics

JANUARY 8, 2024

No member company will agree to use a representation that can potentially be reverse-engineered to reveal the chemical structures of its molecules. Any effort like MELLODDY, where data privacy is the prime concern, will have to compromise on the molecular representation used. Further, private consortia do little to advance the field.

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Drugs Small Molecule Bioinformatics Packaging 141

Dark Matter Blog

AUGUST 31, 2020

The initial discussions that would lead to the PEARL-seq platform involved scanning the literature for the wings, propellers, and engines that we thought we could use. Finally, if we found an rSM that had biological activity, could we correlate that activity with the ability of the rSM to bind RNA?

RNA 52

RNA Small Molecule Bioinformatics Computational Chemistry 52

Codon

MAY 15, 2023

link ) *New base editors can engineer both mitochondrial and nuclear DNA. link ) *Hypoimmune pluripotent cells were engineered and then used for rejection-free transplantation in primates. link ) Engineered Pseudomonas microbes — which eat plant biomass — make isoprenol, a precursor to aviation fuels, with a 3.5

DNA 52

DNA Bioinformatics Engineering RNA 52

Codon

MAY 15, 2023

link ) *New base editors can engineer both mitochondrial and nuclear DNA. link ) *Hypoimmune pluripotent cells were engineered and then used for rejection-free transplantation in primates. link ) Engineered Pseudomonas microbes — which eat plant biomass — make isoprenol, a precursor to aviation fuels, with a 3.5

DNA 52

DNA Bioinformatics Engineering RNA 52

Vial

DECEMBER 5, 2023

Improvements in bioinformatics, robotics, liquid handling, and nucleic acid preparation will continue to transform NGS sequencing methods. We are more than just a CRO — we are “doers” — innovators, engineers, and ClinOps leaders. Conclusion NGS has tremendous potential for advancement and application in clinical research.

Clinical Trials 52

Clinical Trials Trials RNA Bioinformatics 52

The Pharma Data

JANUARY 21, 2021

“Finalists are the top young scientists and engineers in the United States who will someday solve some of the world’s most vexing problems. Our most significant philanthropic commitments are in the area of science education, including the Regeneron Science Talent Search and Regeneron International Science and Engineering Fair.

Science 40

Science Engineering Molecular Biology Bioinformatics 40

The Pharma Data

SEPTEMBER 11, 2021

This precise and rational approach to library fabrication combined with sophisticated bioinformatics and software expertise expedites antibody discovery by decreasing risk, increasing speed, and lowering the failure rate for antibody therapeutic development. About Twist Bioscience Corporation. About Twist Bioscience Corporation.

DNA 52

DNA Bioinformatics Production Engineering 52

The Open Targets Blog

APRIL 25, 2023

Although the estate was undoubtedly pretty, the Hall had seen better days and was rather dominated by a 1950s building that provided laboratories for the light engineering company that had owned the site. ranging from university academics through engineers and clerical staff to the military. The same went for analysis tools.

DNA 52

DNA Government Engineering Laboratories 52

Broad Institute

AUGUST 11, 2022

It’s been very exciting to integrate genetics, bioinformatics, biochemistry, and structural biology approaches in one study to understand this fascinating molecular system.”

DNA 52

DNA Virus Immune Response Bioinformatics 52

Drug Target Review

SEPTEMBER 26, 2024

Mutlu has a robust academic background that includes a bachelor’s degree in physics, a master’s degree in bioengineering, and a PhD in bioinformatics from the University of Cambridge. He also held a genomics consultancy role and worked as an R&D engineer in the speech-to-text domain at Hewlett Packard.

Drugs 64

Drugs Production Research Small Molecule 64

The Pharma Data

JULY 27, 2021

“Over the last five years, Teneobio developed leading-edge expertise in efficiently engineering differentiated multispecific and bispecific therapeutics for numerous indications with potentially better safety, efficacy and pharmacokinetic profiles than the first generation of T-cell engagers. chief executive officer of Teneobio.

Production 52

Production Clinical Trials Government Disease 52

The Open Targets Blog

APRIL 19, 2022

He is now a data engineering technical lead at AstraZeneca. "The To streamline this process, Shyamasree Saha and Santosh Tirunagari from the Europe PMC team at EMBL’s European Bioinformatics Institute began to investigate machine learning approaches.

Disease 52

Disease Bioinformatics FDA Production 52

The Pharma Data

OCTOBER 27, 2020

the phase 2 SAPPHIRE study seeks to evaluate the use of autologous endothelial progenitor cells (EPCs) genetically engineered to express endothelial nitric oxide synthase in patients with PAH taking conventional PAH treatments. Conducted by our Canadian affiliate Northern Therapeutics, Inc.,

FDA 40

FDA Production Licensing Licensing 40

Codon

AUGUST 28, 2024

And finally, people intent on causing harm could engineer pathogens to become more dangerous. But DNA screening tools can't simply flag any sequence that is similar to a potentially dangerous virus because the public databases also include engineered sequences comprising DNA sequences created from multiple different organisms.

DNA 79

DNA Bioinformatics Virus Government 79

Codon

AUGUST 10, 2023

Engineered biology has profound potential to change how we live, but the field has become broad, bloated, nebulous. ” Foundations Basics of Synthetic Biology →Foundations for engineering biology , by Endy D. Link Engineering stability in gene networks by autoregulation , by Becskei A. & Nature (2005).

DNA 91

DNA Cell Biology Molecular Biology Engineering 91

Codon

AUGUST 10, 2023

Engineered biology has profound potential to change how we live, but the field has become broad, bloated, nebulous. ” Foundations Basics of Synthetic Biology →Foundations for engineering biology , by Endy D. Journal of Biological Engineering (2010). Link Engineering Escherichia coli to see light , by Levskaya A.

DNA 52

DNA Cell Biology Engineering Molecular Biology 52

Codon

APRIL 16, 2023

Codon Digest is my weekly roundup of research, news, and industry highlights about engineered biology. These microbes were engineered to express tumor antigens that could “elicit T cells that were licensed by the commensal immune program but specific for a tumor,” including both CD4+ and CD8+ T cells, according to the study.

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Engineering DNA RNA Science 52