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In a new development, a recent paper published in Biology Methods & Protocols by Oxford University Press has highlighted a promising avenue for enhancing vaccine efficacy against infectious pathogens like the COVID-19 virus. The role of extracellular vesicles in COVID-19 virus infection [Internet].
Finally, comprehensive genetic knowledge also facilitates the use of powerful bioinformatic tools that strengthen the cell-line development process, especially for enhanced protein expression or monoclonality assessment. The first concern is microbial contamination.
As it turned out, software engineering teams at the Broad Institute had already created a solution — Terra , an open, secure, and collaborative environment created in a collaboration between Broad, Verily, and Microsoft, where users can analyze and share biomedical and public health data.
It’s been very exciting to integrate genetics, bioinformatics, biochemistry, and structural biology approaches in one study to understand this fascinating molecular system.” These bacterial proteins were instead directly sensing key parts of the virus. The cells underwent a dramatic defensive response and survived.
Recent advances in bioinformatics show clonal neoantigens are the best targets for immunotherapy, as I will elucidate below. Using powerful bioinformatics technology developed and validated with sequence data from the TRACERx study, researchers are able to identify clonal neoantigens from a patient’s unique tumour profile.
link ) *New base editors can engineer both mitochondrial and nuclear DNA. link ) *Hypoimmune pluripotent cells were engineered and then used for rejection-free transplantation in primates. link ) Engineered Pseudomonas microbes — which eat plant biomass — make isoprenol, a precursor to aviation fuels, with a 3.5
link ) *New base editors can engineer both mitochondrial and nuclear DNA. link ) *Hypoimmune pluripotent cells were engineered and then used for rejection-free transplantation in primates. link ) Engineered Pseudomonas microbes — which eat plant biomass — make isoprenol, a precursor to aviation fuels, with a 3.5
Codon Digest is my weekly roundup of research, news, and industry highlights about engineered biology. These microbes were engineered to express tumor antigens that could “elicit T cells that were licensed by the commensal immune program but specific for a tumor,” including both CD4+ and CD8+ T cells, according to the study.
During the COVID-19 pandemic, BenevolentAI used its AI platform to identify baricitinib as a potential treatment for the virus in just three days, an impressive example of rapid repurposing of existing drugs. Recently Recursion Pharmaceuticals unbiased, machine learning-powered genomics screen rapidly identified and advanced REC-1245.
And finally, people intent on causing harm could engineer pathogens to become more dangerous. It is relatively straightforward to detect the first threat―creating a virus from scratch using synthetic DNA—by searching for small fragments of known viral DNA sequences in a customer’s order.
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