Drug Target Review

DECEMBER 28, 2023

In most cancers, the tumour evolves by acquiring mutations that confer growth advantages or resistance to therapies. These neoantigens are identified by T cells of the immune system as foreign proteins and thus trigger an immune response. Neoantigens are recognised as non-self and trigger an immune response.

Bioinformatics 105

Bioinformatics Immune Response DNA Vaccine 105

Drug Target Review

JANUARY 15, 2024

The preclinical results demonstrated significant immune responses and tumour regression. Could you elaborate on the mechanisms by which these responses are initiated within cancer cells? This induced anti-tumour immunity is also detectable by increased innate and adaptive immune cells in the tumour, spleen and blood.

Treatment 106

Treatment Immune Response Therapies Clinical Trials 106

Drug Target Review

DECEMBER 13, 2023

These disease signatures capture both the linear and non-linear effects of genetic and molecular interaction networks and enable the identification of associations including those that are only relevant to a subgroup of patients that influence disease risk, prognosis and/or therapy response.

Bioinformatics 145

Bioinformatics Disease Regulations Immune Response 145

The Anticancer Fund

MARCH 24, 2023

In seeking to understand the difference in response in mCRC, the authors uncover an interplay between oncogenic pathways, and that drug targeting of BRAF ± EGFR causes a compensatory activation of SRC kinases leading to treatment resistance. COX2 inhibition, using celecoxib, reduces PGE2 and averts the resistance to BRAF treatment.

Drugs 52

Drugs DNA Trials Treatment 52

Codon

APRIL 16, 2023

Skin microbes can trigger strong immune responses. These microbes were engineered to express tumor antigens that could “elicit T cells that were licensed by the commensal immune program but specific for a tumor,” including both CD4+ and CD8+ T cells, according to the study. BMC Bioinformatics. McCafferty C.L.

Engineering 52

Engineering DNA RNA Science 52