Drug Target Review

JANUARY 15, 2024

Research 1 has shown that neutrophil elastase selectively and potently kills cancer cells irrespective of their genetics and anatomical origin, mobilises adaptive immunity, and avoids resistance mechanisms. Could you provide insights into the driving factors behind exploring novel treatments for cancer types?

Treatment 106

Treatment Immune Response Therapies Clinical Trials 106

ASPET

JANUARY 23, 2024

Damage-associated molecular patterns (DAMPs) may contribute to both innate and adaptive immune phases of IDRs, and changes in extracellular vesicle (EV) cargo have been detected post-exposure to several IDR-associated drugs.

Immune Response 100

Immune Response Bioinformatics Regulations Drugs 100

Drug Target Review

DECEMBER 13, 2023

The genes unique to the severe long COVID patients were found to be associated with immune pathways such as myeloid differentiation, macrophage foam cells and lipid signalling pathways. The article mentions that TLR4 antagonists have been identified as potential candidates for repurposing long COVID treatment.

Bioinformatics 145

Bioinformatics Disease Regulations Immune Response 145

PLOS: DNA Science

MAY 16, 2024

Other genomic databases were retooled for the huge datasets that COVID was generating, such as the Cloud Institute for Microbial Bioinformatics, begun in 2014 and rechristened the COVID-19 Genomics UK Consortium ( COG-UK ). • identifies parts of the virus to target to provoke an immune response from a vaccine.

Virus 98

Virus DNA RNA Laboratories 98

Codon

AUGUST 27, 2024

For example, many different filoviruses attack white blood cells and cause similar innate immune responses , which makes it difficult to identify a particular species from only their DNA. Putting a sequencer in every port, hospital, water treatment plant, or subway station isn’t feasible just yet due to the expense.

DNA 84

DNA Laboratories Hospitals Virus 84

The Anticancer Fund

MARCH 24, 2023

In seeking to understand the difference in response in mCRC, the authors uncover an interplay between oncogenic pathways, and that drug targeting of BRAF ± EGFR causes a compensatory activation of SRC kinases leading to treatment resistance. COX2 inhibition, using celecoxib, reduces PGE2 and averts the resistance to BRAF treatment.

Drugs 52

Drugs DNA Trials Treatment 52

Codon

APRIL 16, 2023

Skin microbes can trigger strong immune responses. These microbes were engineered to express tumor antigens that could “elicit T cells that were licensed by the commensal immune program but specific for a tumor,” including both CD4+ and CD8+ T cells, according to the study. BMC Bioinformatics. McCafferty C.L.

Engineering 52

Engineering DNA RNA Science 52