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Malaria unravelled: decoding the parasite’s gene expression control

Drug Target Review

Through phylogenetic analysis and microscopy techniques, they identified a nuclear-encoded apicoplast RNA polymerase σ subunit called ApSigma. The initial subject of my research carrier was RNA polymerase principal sigma factors in bacteria. The first identification was based on a bioinformatic analysis.

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How big data analytics can make personalised care a reality

Drug Discovery World

Johannes Goll, Global Head of Emmes’ Biomedical Data Science and Bioinformatics department, explains how big data analytics can deliver improved therapies and bring clinical research one step close to realising the potential of personalised care. Having the workflow in place allowed us to return an updated 500+ page report within two days.

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The use-case for NGS

Drug Discovery World

DDW Editor Reece Armstrong speaks to Dr Darrell Green , Lecturer in RNA Biology Biomedical Research Centre Norwich Medical School University of East Anglia, about his work using next generation sequencing (NGS) and the areas the technology is impacting within drug discovery and development.

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Can Global Genomic Surveillance Forecast the Next Pandemic?

PLOS: DNA Science

That’s thanks to accelerated genome sequencing technologies, expanded laboratory capabilities, and interacting infrastructure on a global level. As soon as the initial RNA genome sequence of the pathogen that would be named SARS-CoV-2 was published, CDC and other organizations began developing diagnostic tests.

Virus 93
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Defense-Forward Biosecurity

Codon

When doctors sequenced the DNA and RNA found in Alice’s blood and synovial fluid—the liquid that surrounds and lubricates joints—they found abnormally low levels of genes encoding iron-storing proteins and high levels of epidermal growth factor receptor RNA. At least nine laboratories outside the U.S.

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Is That DNA Dangerous?

Codon

A concerned employee at a laboratory supply company had called the Centers for Disease Control, or CDC, after fielding repeated calls from Harris asking when his samples of plague would arrive in the mail. 5 But it could match up to one of the threats in your reference database, so you opt to throw a battery of bioinformatics tools at it.

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What to expect from PEGS Europe 2023: Day 3

Drug Discovery World

Novel/alternative ML-enabled screening technologies for higher POS Following chairperson’s remarks from M Frank Erasmus, PhD, Head, Bioinformatics, Specifica, there will be four presentations and a panel discussion. Jana Langhoff, Tecan, on: ‘Opportunities and challenges of automating high throughput protein purification’.