Drug Target Review

JULY 12, 2023

In April 2023, we presented preliminary safety data at the AACR Annual Meeting where our lead product candidate was observed to be well tolerated with no dose limiting toxicities observed in cancer patients through the first four dose levels. We are pleased that to date our lead product candidate has aligned DCI profiles as expected.

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Biochemical Assays Treatment Bioinformatics Disease 98

DrugBank

JUNE 5, 2023

In the middle of May, we packed up our bags, our conference booth, and one USB stick with a presentation about the future of Data-Centric AI and hit the road to Boston for the 2023 BioIT World Conference & Expo. There were several excellent presentations on how to use AI/ML/data science to advance drug discovery efforts.

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Bioinformatics Clinical Trials Science Drugs 98

The Open Targets Blog

OCTOBER 24, 2023

Amir Feizi is the Director of Bioinformatics at OMass Therapeutics, a spinout from Professor Dame Carol Robinson’s Laboratory at the University of Oxford. Their work was recently published in Bioinformatics. We chat with him about otargen, and the importance of sharing open-source resources within the bioinformatics community.

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Bioinformatics Packaging Pharmaceutical Companies Pharma Companies 62

DrugBaron

NOVEMBER 22, 2022

Most proteomics methodology used today provides an enumeration of the major proteins present with poorly validated attempts at quantitation and even less focus on the subtly different variants of each “protein” present in the mixture.

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Bioinformatics Regulations Molecular Biology Engineering 100

Drug Target Review

MARCH 28, 2024

Accelerating characterisation While there is substantial evidence supporting natural products as a high-quality source of potential drug leads, the process of discovering such molecules presents various challenges, including the scope of unknown chemistry and biological function. References Newman DJ, Cragg GM.

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Production Drugs Small Molecule Bioinformatics 128

The Pharma Data

OCTOBER 21, 2020

Seven poster presentations are available at ir.unither.com. ” The research, The Impact of Inhaled Treprostinil on Patient Lung Function: Results from the INCREASE Study, was presented by Aaron Waxman , M.D., SILVER SPRING, Md. and RESEARCH TRIANGLE PARK, N.C. , SILVER SPRING, Md.

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The Open Targets Blog

FEBRUARY 29, 2024

  With a background in biochemistry and bioinformatics, Lucy was interested in exploring how bioinformatics was applied to real-world healthcare data. I just graduated with a degree in Bioinformatics, and I was interested to see how the skills I learned could be applied. Was there anything surprising about your results?

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International Bioinformatics RNA Disease 57

Drug Target Review

JANUARY 15, 2024

Additionally, in evaluating the effectiveness of our initial pipeline asset, we sought tumours suitable for intratumoural injection that present surface-accessible lesions. Activation of the ELANE pathway appears pivotal. How does this activation align with the distinctive characteristics of the various cancers you are working with?

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Treatment Immune Response Therapies Clinical Trials 105

Practical Cheminformatics

JANUARY 8, 2024

In November and December, several large pharmas held “AI Day” presentations featuring LLM applications for clinical trial data analysis. A paper by Bran and coworkers from EFPL and the University of Rochester presented ChemCrow, a system for integrating Chemistry capabilities into LLMs.

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Nvidia Developer: Drug Discovery

DECEMBER 19, 2023

HiFi-NN annotates protein sequences with enzyme commission (EC) numbers beating the current bioinformatics tool of choice ( blastp ), as well as other SoTA DL models, including CLEAN , in precision and recall (Table 1).

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Science Small Molecule Bioinformatics Research 102

Codon

AUGUST 27, 2024

” These are short sequences of DNA that are highly conserved, meaning they are likely to be present in a wide variety of sequences. While reading all the sequences present in a sample, researchers want to find any that are out of place, such as those that belong to a never-before-seen virus.

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Drug Target Review

MAY 27, 2024

His research expertise focused on the use of genomics in translational oncology with a focus on clinical trials, genomically-informed drug combinations, liquid biopsy & MRD, and creating novel bioinformatic pipelines for cancer genome analyses.

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Clinical Trials Science Molecular Biology Bioinformatics 59

The ChEMBL-og

MARCH 13, 2023

The next UKQSAR meeting will be held at the European Bioinformatic Institute (EBI) on 20th April. Suggested reading [link] [link] [link] FOR POSTER PRESENTERS As part of the registration process, you will be offered to submit an abstract. This is where the ChEMBL team is also located! See below for the official announcement.

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Bioinformatics Research Drugs 52

Drug Target Review

APRIL 11, 2025

While traditional artificial intelligence/machine learning (AI/ML) offers some benefits, generative AI, particularly when integrated with clinical genomics, presents a transformative opportunity. Examples of large-scale applications and future perspectives are presented.

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Clinical Development Drugs Pharmaceuticals Clinical Trials 52

The Open Targets Blog

AUGUST 7, 2023

Following my interest in natural sciences, I moved to Novosibirsk (central Siberia) as soon as I was able, to study general biology, with a focus on statistical genetics and bioinformatics. My PhD was about non-additive effects of genes in the human metabolome (the collection of metabolites present in human blood).

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Bioinformatics Disease Science 52

The Pharma Data

MARCH 20, 2021

presented the. Bioinformatics in the Faculty. Medicine in Oxford, Biogazelle, a biotechnology company in Ghent, and the Centre For Proteome Research at the University of Liverpool. Highlight #1 Dr. Neil Ashley, the Single-Cell Core Facility Manager at the Weatherall Institute of Molecular Medicine (WIMM) in Oxford, U.K., The MANTIS.

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Laboratories Virus RNA Bioinformatics 52

Broad Institute

MARCH 11, 2024

A comment on your comfort level with bioinformatics, images, and custom analysis. If we decide to run the data in batches, we will be available for interim meetings where we will present QC metrics and share impressions before proceeding to the next batch.

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RNA Bioinformatics International Clinical Trials 52

Drug Target Review

SEPTEMBER 26, 2024

While these models present an informed starting point, it’s important to integrate these insights with human expertise to navigate the complexities of drug discovery.

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The Open Targets Blog

APRIL 19, 2022

To streamline this process, Shyamasree Saha and Santosh Tirunagari from the Europe PMC team at EMBL’s European Bioinformatics Institute began to investigate machine learning approaches. “From the beginning, we knew that deep learning would be the solution,” says Shyamasree.

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The Pharma Data

JULY 27, 2021

Teneobio’s discovery platform, TeneoSeek, comprises genetically engineered animals (UniRat® and OmniFlic®), next-generation sequencing, bioinformatics and high-throughput vector assembly technologies. About Teneobio Teneobio, Inc.

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Production Clinical Trials Government Disease 52

The Pharma Data

DECEMBER 8, 2020

. “ TETON represents a significant move outside the pulmonary hypertension space, but based on data collected during the recent INCREASE study we’re confident that inhaled treprostinil can help address clinical gaps presented by existing therapies in IPF.”

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The Open Targets Blog

APRIL 25, 2023

Each Christmas presented the opportunity for the leaders to make fools of themselves in the annual pantomime, a tradition which we had inherited from the MRC Laboratory of Molecular Biology (LMB) in Cambridge and perhaps from earlier scientists who had known ENSA during service in the War. Comput Appl Biosci 13, 523–535 (1997).

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The Pharma Data

OCTOBER 27, 2020

A reconciliation of net income to non-GAAP earnings is presented below (in millions, except per share data): . ” We also presented a poster at the October 2020 CHEST annual meeting detailing improvements in forced vital capacity associated with safety observations during the INCREASE study. .

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The Pharma Data

SEPTEMBER 1, 2020

These data (Presentation #P0217) will be presented at the MSVirtual2020: 8th Joint ACTRIMS-ECTRIMS Meeting. At the MSVirtual2020: 8th Joint ACTRIMS-ECTRIMS Meeting, Bristol Myers Squibb and collaborators will present 15 clinical and non-clinical abstracts that reinforce the breadth and depth of the company’s research in MS.

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Treatment Clinical Trials Trials Disease 52

Codon

APRIL 16, 2023

This was no small feat, because moths respond to a complex mixture of two or three different molecules that must be present at specific ratios. BMC Bioinformatics. Tobacco plants were genetically-engineered to produce moth sex pheromones. Read Deep learning of genomic contexts predicts protein co-regulation and function.

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Engineering DNA RNA Science 52

Chemical Biology and Drug Design

FEBRUARY 5, 2025

ABSTRACT Luteolin and quercetin, which are flavonoids, are present in various traditional Chinese medicines. Bioinformatic analyses were performed to identify potential target genes and pathways regulated by luteolin/quercetin during adipogenesis.

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RNA Bioinformatics Regulations Research 100

Drug Target Review

FEBRUARY 11, 2025

Each stage presents its own set of complexities and potential delays. Managing this data deluge requires the expertise of multidisciplinary fields like clinical bioinformatics , which bridges statistics, biology and computer science. Clinical bioinformatics desiderata for Molecular Tumor Boards.

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Drug Target Review

MARCH 13, 2025

This presents a significant hurdle for investors, as reliable benchmarks for assessing investment opportunities may be limited. His leadership has driven international commercial success in areas including image analysis, data management, bioinformatics, advanced clinical trial data analysis leveraging machine learning and federated learning.

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Drug Development Science Clinical Trials FDA 59

Conversations in Drug Development Trends

APRIL 7, 2025

Solid tumors present a significant challenge to clinical research due to their complex and heterogeneous nature. However, the emergence of precision medicine is revolutionizing the way we approach these tumors, offering new hope and innovative solutions.

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Research Clinical Trials Trials Clinical Research 40

Codon

AUGUST 10, 2023

Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link The Systems Biology Graphical Notation , by Le Novère N. Nature Biotechnology (2009). Link Subscribe to get future posts. Nature (2017). Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Synthesis.cc (2022).

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DNA Cell Biology Molecular Biology Engineering 98

Codon

AUGUST 10, 2023

Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link The Systems Biology Graphical Notation , by Le Novère N. Nature Biotechnology (2009). Link Subscribe to get future posts. Nature (2017). Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Synthesis.cc (2022).

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DNA Cell Biology Engineering Molecular Biology 52