DrugBaron

NOVEMBER 22, 2022

For example, it is well known that glycation of haemoglobin through non-enzymatic reaction with glucose to generate a product known as Hba1c is a useful measure of glycemic control in diabetic subjects. This can be useful to quantify protein adducts (for example when radiolabelling a protein or preparing antigens for vaccine production).

Bioinformatics 100

Bioinformatics Regulations Molecular Biology Engineering 100

Drug Target Review

JANUARY 15, 2024

It generates potent tumour cytotoxicity, induces productive changes in the immune compartment, and avoids resistance mechanisms. N17350’s mechanism of action delivers three unique attributes for a cancer drug.

Treatment 105

Treatment Immune Response Therapies Clinical Trials 105

The Pharma Data

MARCH 20, 2021

Fermentation is used in the production of renewable feedstocks for food products and ingredients, beverages, pharmaceutical compounds, nutraceuticals, through to fine and bulk chemicals. In this regard, Martin Hoogedoorn, Product Specialist at Elscolab Nederland B.V., Scope of possible application .

Bioinformatics 52

Bioinformatics Laboratories Production Engineering 52

DrugBank

JUNE 5, 2023

Chris Klinger, Scientific Support Lead, Bioinformatics LinkedIn It sounds like there was a lot going on at BioIT, what were your highlights? It made me realize that there are some parts of our products and data that I take for granted, where we have solved problems that are still challenging some parts of industry, and where we could help.

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Bioinformatics Clinical Trials Science Drugs 98

The Pharma Data

NOVEMBER 25, 2020

Egle has leveraged its unique bioinformatic and translational capabilities to successfully identify targets that will now be pursued under the terms of the alliance. We look forward to continuing our productive alliance with Takeda while pushing further our internal programs through the equity component of the alliance.”. “We

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Research Bioinformatics Pharmaceutical Companies Engineering 52

The Open Targets Blog

AUGUST 13, 2024

Building and Sustaining I have huge admiration for the incredible teams at EMBL’s European Bioinformatics Institute and beyond who build and sustain knowledge resources for the community. I am really excited about bringing this to life with the team and where it will take us.

Bioinformatics 70

Bioinformatics Disease Treatment Drugs 70

Drug Target Review

SEPTEMBER 30, 2024

Therefore, once we define a desired target product profile (TPP), we spend months in the lab collecting billions of measurements and accumulating data to train a model that will generate an antibody that is manufacturable and meets our functional requirements. The space of possible parameters is too vast and the available data is too scant.

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Bioinformatics Clinical Trials Clinical Development Treatment 64

Dark Matter Blog

AUGUST 31, 2020

Sites where the probes crosslinked to the RNA could then be determined by reverse transcription (RT) – RT enzymes typically cannot “read through” the bulky photoadduct and thus affords a truncated cDNA product. Our expedition gains altitude After that initial result, it was all hands on deck.

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RNA Small Molecule Bioinformatics Computational Chemistry 52

The Pharma Data

JULY 27, 2021

Teneobio’s discovery platform, TeneoSeek, comprises genetically engineered animals (UniRat® and OmniFlic®), next-generation sequencing, bioinformatics and high-throughput vector assembly technologies. Further, preclinical results do not guarantee safe and effective performance of product candidates in humans.

Production 52

Production Clinical Trials Government Disease 52

The Pharma Data

SEPTEMBER 11, 2021

This precise and rational approach to library fabrication combined with sophisticated bioinformatics and software expertise expedites antibody discovery by decreasing risk, increasing speed, and lowering the failure rate for antibody therapeutic development. About Twist Bioscience Corporation.

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DNA Bioinformatics Production Engineering 52

Practical Cheminformatics

JANUARY 8, 2024

It would be far more productive to privately or publicly fund an effort to generate large, relevant datasets and make the data publicly accessible. Talented scientists in academia or non-consortium companies will not have the opportunity to contribute, and there will be limited opportunities to compare notes on what works and what doesn’t.

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Drugs Small Molecule Bioinformatics Packaging 139

Drug Target Review

SEPTEMBER 26, 2024

Dr Mutlu Dogruel is the VP of AI Solutions, who has outlined a forward-thinking vision to revolutionise drug discovery processes by integrating cutting-edge AI technologies to enhance productivity, streamline workflows, and empower researchers. We are currently integrating our products with generative chemistry and AI chatbots.

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Drugs Production Research Small Molecule 64

The Premier Consulting Blog

JUNE 18, 2023

2 While the randomized clinical trial remains the gold standard for regulatory approval, the FDA noted in the report that in silico clinical trials can be used to evaluate medical products in special circumstances, such as when human clinical trials may be unethical, or for augmenting human trials (e.g.

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The Pharma Data

JANUARY 24, 2021

Diversigen provides consultative end-to-end solutions for sequencing, bioinformatics, and statistical analysis for the study of the microbiome of living organisms and environments. Diversigen, Inc.

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The Pharma Data

DECEMBER 27, 2020

Tyvaso DPI, previously referred to as Treprostinil Technosphere ® , is an investigational drug-device combination product comprised of a dry powder formulation of treprostinil and a small, portable, dry powder inhaler. About Tyvaso DPI. About TYVASO ® (treprostinil) Inhalation Solution. INDICATION. ADVERSE REACTIONS.

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FDA Bioinformatics Disease Production 52

DrugBank

MARCH 15, 2023

The moment you decide which DrugBank license or products best suit your needs isn’t the final step in our relationship, it is just the beginning. We also host product demonstrations. Based on our knowledge of your work we will curate the content that best meets your goals.

Licensing 52

Licensing Licensing International Bioinformatics 52

The Pharma Data

DECEMBER 16, 2020

This includes Evotec’s data analysis platform “PanHunter”, a proprietary, integrated, user-centred bioinformatics platform which facilitates the analysis of PanOmics data integrated with other metadata sets.

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Targeted Protein Degradation Bioinformatics Disease Drugs 40

Agency IQ

OCTOBER 12, 2023

CDER expects all FY 2024 new molecular entity reviews to go through this streamlined template, with some exceptions for oncology products. Joneckis said that CBER has “some limited uses that we have seen in external submissions, mostly in the bioinformatics area,” but not as many as CDER. With 15 gene therapies now approved in the U.S.,

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FDA Clinical Trials International Drugs 40

Codon

AUGUST 27, 2024

These laboratories share data and bioinformatics tools that enabled the early detection of SARS-CoV-2 and monkeypox even before their reference genomes were available. That price tag seems worthwhile if the sequencing data leads to earlier treatment, faster recovery to productivity, and ultimately lives saved.

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DNA Laboratories Hospitals Virus 97

The Open Targets Blog

APRIL 19, 2022

From one of the many possible implementations that answers the question, we chose a word2vec approach as it is reproducible, unsupervised, and production-ready. In the context of this post, we will focus on the first question. It is still one of the most used for linguistic tasks. “It’s a beautiful project.

Disease 52

Disease Bioinformatics FDA Production 52

Codon

MAY 15, 2023

coli universal chassis with reprogrammed metabolic flux suppresses overflow metabolism, enhancing the production and yield of chemicals and proteins, paving the way for efficient bioproduction strain design. Bioinformatics. Bioinformatics. Science Robotics. link ) CReATiNG is a technique to build synthetic chromosomes in yeast.

DNA 52

DNA Bioinformatics Engineering Virus 52

Codon

MAY 15, 2023

coli universal chassis with reprogrammed metabolic flux suppresses overflow metabolism, enhancing the production and yield of chemicals and proteins, paving the way for efficient bioproduction strain design. Bioinformatics. Bioinformatics. Science Robotics. link ) CReATiNG is a technique to build synthetic chromosomes in yeast.

DNA 52

DNA Bioinformatics Engineering Virus 52

The Pharma Data

DECEMBER 8, 2020

This exclusivity would also benefit Treprostinil Technosphere ® , United Therapeutics’ next-generation dry powder inhalation form of treprostinil, upon FDA approval of that product for the IPF indication. Chairman and Chief Executive Officer of United Therapeutics. Caution should be used when selecting a dose for geriatric patients.

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FDA Treatment Drugs FDA Approval 40

The Pharma Data

JANUARY 21, 2021

Founded and led for 30 years by physician-scientists, our unique ability to repeatedly and consistently translate science into medicine has led to eight FDA-approved treatments and numerous product candidates in development, all of which were homegrown in our laboratories.

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Science Engineering Molecular Biology Bioinformatics 40

The Pharma Data

JANUARY 10, 2021

I actually think neuroscience is going to heat up in 2021,” said Ben Zeskind , co-founder and CEO of Immuneering , which is using bioinformatics and computational biology to develop new drugs in this space, along with oncology and immuno-oncology. Moving on From the Amyloid Hypothesis. “I And then, always, ‘science matters.’

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Vaccine Disease Regulations Small Molecule 52

The Pharma Data

OCTOBER 21, 2020

Vice President of Product Development at United Therapeutics. There are no data on the presence of treprostinil in human milk, the effects on the breastfed infant, or the effects on milk production. It is not known whether treprostinil is excreted in human milk or if it affects the breastfed infant or milk production.

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Disease Treatment Therapies Production 40

The Pharma Data

OCTOBER 27, 2020

“As our core business continues to perform well, we have a solid footing to enter 2021 with several key product launches including the potential INCREASE product label expansion for Tyvaso, the Remunity Pump for Remodulin, and the Implantable System for Remodulin,” said Martine Rothblatt , Ph.D., SILVER SPRING, Md.

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FDA Production Licensing Licensing 40

The Pharma Data

SEPTEMBER 1, 2020

Presentation Topic: Biomarkers and Bioinformatics. This press release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995 regarding, among other things, the research, development and commercialization of pharmaceutical products. Author: Harris. Presentation Number: P0118.

Clinical Trials 52

Clinical Trials Treatment Trials Disease 52

Drug Target Review

FEBRUARY 11, 2025

The ongoing transformation is leading to the gradual replacement of traditional processes with more dynamic and data-driven models, with the primary objective of improving clinical success rates and productivity. Clinical bioinformatics desiderata for Molecular Tumor Boards. Refining the impact of genetic evidence on clinical success.

Drug Development 59

Drug Development Bioinformatics Drugs Small Molecule 59

Drug Target Review

MARCH 13, 2025

His leadership has driven international commercial success in areas including image analysis, data management, bioinformatics, advanced clinical trial data analysis leveraging machine learning and federated learning. FDA Proposes Framework to Advance Credibility of AI Models Used for Drug and Biological Product Submissions [Internet].

Drug Development 59

Drug Development Clinical Trials Science FDA 59

Codon

APRIL 16, 2023

BMC Bioinformatics. Read Easy modular integrative fuSion-ready Expression (Easy-MISE) toolkit for fast engineering of heterologous productions in Saccharomyces cerevisiae. Read Deep learning of genomic contexts predicts protein co-regulation and function. Read ICOR: improving codon optimization with recurrent neural networks.

Engineering 52

Engineering DNA RNA Science 52

Codon

AUGUST 10, 2023

Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link An integrated cell-free metabolic platform for protein production and synthetic biology , by Jewett M.C. Link Production of the antimalarial drug precursor artemisinic acid in engineered yeast , by Ro D-K. Nature Biotechnology (2009). Nature (2017).

DNA 97

DNA Cell Biology Molecular Biology Engineering 97

Codon

AUGUST 10, 2023

Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link An integrated cell-free metabolic platform for protein production and synthetic biology , by Jewett M.C. Link Production of the antimalarial drug precursor artemisinic acid in engineered yeast , by Ro D-K. Nature Biotechnology (2009). Nature (2017).

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DNA Cell Biology Engineering Molecular Biology 52