Chemical Biology and Drug Design

JUNE 21, 2023

Hsa-miR-503-5p expression in LUAD and the target gene downstream of hsa-miR-503-5p was predicted by bioinformatics analysis. The results showed that hsa-miR-503-5p showed high expression, while its target gene CTDSPL presented decreased expression in LUAD.

Regulations 100

Regulations Protein Expression Bioinformatics Drugs 100

Chemical Biology and Drug Design

AUGUST 20, 2023

Hederagenin attenuated HG-induced increase in mRNA and protein expression of NLRP3, ASC, and IL-1β. Bioinformatics analysis predicted cathepsin B (CTSB) as a target of hederagenin to modulate NOD-like receptor (NLR) pathway. Hederagenin also suppressed HG-induced increase in mRNA and secretion levels of FN, Col.

Bioinformatics 100

Bioinformatics Protein Expression Research 100

Chemical Biology and Drug Design

AUGUST 9, 2023

A label-free proteomics technology was employed to investigate alterations in protein expression in LoVo cells treated with plumbagin. The LC-MS/MS proteomics assay revealed 78 proteins that were differentially expressed upon treatment with plumbagin.

Bioinformatics 100

Bioinformatics Protein Expression Treatment Research 100

Drug Discovery World

SEPTEMBER 25, 2024

DISCO’s approach is to analyse the “surfaceome” of cancer cells – the totality of all proteins expressed on the cell surface – looking for ways that diseased tissue is differentiated from normal tissue. Ries noted that there are other things to think about aside from finding targets expressed only on tumour cells. .”

Therapies 162

Therapies Pharma Companies FDA Approval FDA 162

Drug Discovery World

NOVEMBER 8, 2023

Cell line and systems engineering The sixth track of PEGS Europe 2023 is Cell Line and Systems Engineering, which will feature a range of sessions made up of presentations, talks and posters which cover applying data science to enhance protein expression, and engineering and developing host cell lines. Claes Gustafsson, Ph.D,

Engineering 162

Engineering Protein Expression Therapies Science 162

Drug Target Review

APRIL 5, 2024

Together, these attributes provide a strong foundation for protein expression with enough adaptability to produce much of the commercial and therapeutic protein market.

Protein Production 96

Protein Production Protein Expression Bioinformatics Production 96

Drug Discovery World

NOVEMBER 30, 2023

This presentation covered three primary drivers for a protein expression model: speed, cost and sustainability. “It

Protein Expression 147

Protein Expression Engineering DNA Therapies 147