Chemical Biology and Drug Design

NOVEMBER 27, 2023

A6 play anticancer role by regulating Best1 and HIST1H2BJ. Moreover, bioinformatic analysis and cell viability test showed A6 plays anticancer role by regulating Best1 and HIST1H2BJ. A6 significantly disrupted the amino acid metabolism, inhibited migration and invasion and induced apoptosis of MCF-7.

Bioinformatics 100

Bioinformatics RNA Regulations Therapies 100

Chemical Biology and Drug Design

JANUARY 1, 2024

Then, Bioinformatics was applied to sort out the candidate interacting with Stachydrine as well as its expression and downstream target in BC. Abstract Considering the therapeutic efficacy of Stachydrine on breast cancer (BC), this study aims to decipher the relevant mechanism.

Bioinformatics 100

Bioinformatics Regulations Disease Research 100

Chemical Biology and Drug Design

DECEMBER 28, 2023

LINC00460 knockdown contributed to DDP sensitivity of cervical cancer by regulating TGFBI, providing a novel mechanism underlying the acquisition of DDP sensitivity. In present study, LINC00460 was screened out through bioinformatics analysis. However, its effect on DDP sensitivity in cervical cancer remains poorly understood.

Bioinformatics 100

Bioinformatics RNA Regulations Drugs 100

ASPET

APRIL 5, 2024

PTP4A3 is thought to regulate multiple oncogenic signaling pathways, including STAT3, SRC, and ERK. Bioinformatic network analyses indicated alterations in cellular signaling nodes. The oncogenic protein tyrosine phosphatase PTP4A3 is frequently overexpressed in human ovarian cancers and is associated with poor patient prognosis.

Bioinformatics 100

Bioinformatics Therapies Regulations 100

ASPET

JANUARY 23, 2024

Proteomic and bioinformatic analyses demonstrated an increased number of differentially expressed proteins with clozapine that were enriched in pathways related to inflammation, myeloid cell chemotaxis, wounding, transforming growth factor (TGF)-β signaling, and negative regulation of stimuli response.

Immune Response 100

Immune Response Bioinformatics Regulations Drugs 100

Elrig

MARCH 25, 2025

Prof Rory Johnson is an Associate Professor at University College Dublin, where his research focusses on uncovering the roles of long noncoding RNAs (lncRNAs) in human health and disease using an interdisciplinary combination of bioinformatic and experimental methods.

RNA 59

RNA Bioinformatics Science Pharmacokinetics 59

Drug Target Review

JULY 24, 2023

Researchers from Tokyo Tech’s World Research Hub Initiative conducted a study to investigate the regulation of gene expression in the apicoplast of the malaria parasite Plasmodium falciparum. The first identification was based on a bioinformatic analysis. What is the main focus of the recent study conducted?

RNA 98

RNA Regulations Bioinformatics Laboratories 98

Broad Institute

AUGUST 7, 2024

At the Broad, he directs the Cancer Genome Computational Analysis Group , and he is a professor of pathology at Harvard Medical School and director of bioinformatics at Massachusetts General Hospital. She has developed innovative approaches to viral diagnostics and novel systems biology approaches to gene regulation and gene therapy.

Medical Schools 90

Medical Schools Hospitals Bioinformatics Vaccine 90

Drug Target Review

MARCH 19, 2024

These genes have a broad range of function including gene regulation particularly in relation to the metabolism of sugars, lipids, and mitochondrial function (among other pathways). Murray has used his expertise in bioinformatics to establish an internationally recognised laboratory specialising in complex trait genomics.

Laboratories 105

Laboratories Bioinformatics International Research Laboratories 105

DrugBaron

NOVEMBER 22, 2022

But data is accumulating to suggest it matters a lot: resolving one variant from another – and understanding what drives their relative concentrations – may be just as important in biology as regulation of gene expression.

Bioinformatics 100

Bioinformatics Regulations Molecular Biology Engineering 100

Vial

DECEMBER 5, 2023

The application of NGS has given researchers deep insights into genetic variation, gene expression, epigenetic modifications, alternative splicing, non-coding RNA regulation, microbial diversity, and various biological processes and diseases. In addition, NGS facilitates transcriptomics , epigenomics, metagenomics, and other omics studies.

Clinical Trials 52

Clinical Trials Trials RNA Bioinformatics 52

The Pharma Data

JANUARY 10, 2021

I actually think neuroscience is going to heat up in 2021,” said Ben Zeskind , co-founder and CEO of Immuneering , which is using bioinformatics and computational biology to develop new drugs in this space, along with oncology and immuno-oncology. 2020 Was Educational for Industry & Regulators.

Vaccine 52

Vaccine Disease Regulations Small Molecule 52

The Pharma Data

JULY 27, 2021

Teneobio’s discovery platform, TeneoSeek, comprises genetically engineered animals (UniRat® and OmniFlic®), next-generation sequencing, bioinformatics and high-throughput vector assembly technologies. About Teneobio Teneobio, Inc. Our business may be impacted by government investigations, litigation and product liability claims.

Production 52

Production Clinical Trials Government Disease 52

Codon

AUGUST 28, 2024

One way to detect toxin-coding genes is to store the genomes of regulated pathogens and any genes that encode regulated toxins in a new database. Also, such screening must take into account that many regulated toxins have beneficial applications. Bioinformatic results from SecureDNA. For now, the U.S.

DNA 90

DNA Bioinformatics Virus Government 90

Broad Institute

JANUARY 24, 2024

Through Terra, researchers can gain access to genomics and other data modalities used for biomedical research, as well as run state-of-the-art workflows developed by Broad and wider bioinformatics community. health system customers and Data Processor Agreements for customers regulated by GDPR.

Bioinformatics 140

Bioinformatics Compliance Science Research 140

Chemical Biology and Drug Design

FEBRUARY 5, 2025

Differentially expressed genes (DEGs) involved in luteolin and quercetin action that regulate adipogenic differentiation were identified using RNA sequencing (RNA-seq). Bioinformatic analyses were performed to identify potential target genes and pathways regulated by luteolin/quercetin during adipogenesis.

RNA 100

RNA Bioinformatics Regulations Research 100

Drug Target Review

MARCH 13, 2025

The journey from distrust to collaboration among industry, academia and regulators will expedite integration, minimise clinical failures and enhance economic sustainability. FDA Perspective on the Regulation of Artificial Intelligence in Health Care and Biomedicine. Lifescienceleader.com. 2024 [cited 2025 Feb 7]. JAMA [Internet].

Drug Development 59

Drug Development Science Clinical Trials FDA 59

Codon

APRIL 16, 2023

Read Deep learning of genomic contexts predicts protein co-regulation and function. BMC Bioinformatics. Read RIP-PEN-seq identifies a class of kink-turn RNAs as splicing regulators. Rea Chromatin context-dependent regulation and epigenetic manipulation of prime editing. Schofield J.A. & & Hahn S. Cell Reports.

Engineering 52

Engineering DNA RNA Science 52

Codon

AUGUST 10, 2023

Link Gene Expression & Regulation →Genetic regulatory mechanisms in the synthesis of proteins , by Jacob F. & Gene Expression and Regulation. Link Biological Networks & Mathematics →Network motifs in the transcriptional regulation network of Escherichia coli , by Shen-Orr S.S. & Xie X.S. Cell (2002).

DNA 97

DNA Cell Biology Molecular Biology Engineering 97

Codon

AUGUST 10, 2023

Link Gene Expression & Regulation →Genetic regulatory mechanisms in the synthesis of proteins , by Jacob F. & Gene Expression and Regulation. Link Biological Networks & Mathematics →Network motifs in the transcriptional regulation network of Escherichia coli , by Shen-Orr S.S. & Xie X.S. PNAS (2012).

DNA 52

DNA Cell Biology Engineering Molecular Biology 52