Drug Target Review

JULY 24, 2023

Through phylogenetic analysis and microscopy techniques, they identified a nuclear-encoded apicoplast RNA polymerase σ subunit called ApSigma. The initial subject of my research carrier was RNA polymerase principal sigma factors in bacteria. The first identification was based on a bioinformatic analysis.

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RNA Regulations Bioinformatics Laboratories 98

Drug Target Review

MAY 24, 2024

2 AlphaFold 3 has been built to model DNA, RNA and smaller molecules (ligands). 5 Several major technology areas are not included above, such as cheminformatics and bioinformatics. Google DeepMind’s new AI can model DNA, RNA, and ‘all life’s molecules’. The latest exciting advancement is AlphaFold 3, which was just released.

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RNA DNA Bioinformatics Science 59

Drug Discovery World

DECEMBER 26, 2023

Otsuka Pharmaceutical and Ionis Pharmaceuticals Otsuka Pharmaceutical and RNA therapy company Ionis have entered into a licence agreement for Otsuka to acquire exclusive marketing rights to Ionis’ hereditary angioedema (HAE) drug candidate donidalorsen in Europe.

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Small Molecule Drugs Molecular Biology Bioinformatics 130

Drug Target Review

MAY 27, 2024

By identifying proteins that only interact with each other in cancer, but not normal tissues, we can really expand the repertoire of ADC therapeutics beyond monoclonal antibodies developed based solely on RNA expression profiles. His work has been published in many high-impact journals and presented at international oncology meetings.

Clinical Trials 59

Clinical Trials Science Molecular Biology Bioinformatics 59

Broad Institute

MARCH 11, 2024

What other data have you collected from these samples (especially RNA-seq/scRNA-seq) Share any images you have of your samples H&E, immunofluorescence, ISH. A comment on your comfort level with bioinformatics, images, and custom analysis. If you don’t have any of your samples, a literature example can still be very helpful.

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RNA Bioinformatics International Clinical Trials 52

Drug Discovery World

APRIL 6, 2023

These topics will be represented across a range of session types, including methods workshops, minisymposia, poster and plenary sessions, as well as keynotes, awards and lectures.

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Small Molecule Targeted Protein Degradation Clinical Trials Engineering 130

Drug Discovery World

OCTOBER 25, 2023

DDW Editor Reece Armstrong speaks to Dr Darrell Green , Lecturer in RNA Biology Biomedical Research Centre Norwich Medical School University of East Anglia, about his work using next generation sequencing (NGS) and the areas the technology is impacting within drug discovery and development.

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Bioinformatics Pharmacogenetics RNA Medical Schools 288

Drug Discovery World

FEBRUARY 6, 2023

Johannes Goll, Global Head of Emmes’ Biomedical Data Science and Bioinformatics department, explains how big data analytics can deliver improved therapies and bring clinical research one step close to realising the potential of personalised care. Figure 2: Advanced data visualisation examples for transcriptomics data.

Bioinformatics 130

Bioinformatics RNA Vaccine Clinical Trials 130

Dark Matter Blog

AUGUST 31, 2020

Our overall mission at Arrakis is to expand the set of “druggable” targets for small-molecule medicines to include RNA. Today, we are pleased to announce that our article describing one such platform: “ PEARL-seq, A Photoaffinity Platform for the Analysis of Small Molecule-RNA Interactions ” was published in ACS Chemical Biology.

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RNA Small Molecule Bioinformatics Computational Chemistry 52

Drug Discovery World

JULY 11, 2023

Now, with the growth of publicly available genomics, transcriptomics, and proteomics databases, the ability to quickly carry out large-scale DNA, RNA, and protein screenings, and the availability of massive sets of de-identified patient data, the amount of high-value, analysable data has reached enormous proportions.

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Science Drugs FDA Engineering 100

Drug Discovery World

JULY 26, 2023

This leap in understanding, which has been facilitated by the emergence of next generation sequencing (NGS) technologies and bioinformatics tools such as artificial intelligence (AI), has brought forward a new wave of precision medicine resources, diagnostics, and therapeutics specifically aiming to leverage the microbiome.

Bioinformatics 130

Bioinformatics Clinical Trials DNA Disease 130

Elrig

APRIL 29, 2024

With a background in Bioinformatics and Computational Biology, she has a keen interest in using technology to solve problems in healthcare and medicine. She has played a key role inbuilding the target identification platform and a proprietary database of transcriptome-wide, functional RNA structures.

Bioinformatics 59

Bioinformatics Molecular Biology Drugs Cell Based Assays 59

Codon

AUGUST 28, 2024

5 But it could match up to one of the threats in your reference database, so you opt to throw a battery of bioinformatics tools at it. BLAST is covered in every introductory bioinformatics course and the 1990 paper introducing has over 110,000 citations. Bioinformatic results from SecureDNA. Bioinformatic results from HMMScan.

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DNA Bioinformatics Virus Government 88

PLOS: DNA Science

MAY 16, 2024

As soon as the initial RNA genome sequence of the pathogen that would be named SARS-CoV-2 was published, CDC and other organizations began developing diagnostic tests. After sequencing, artificial intelligence adds context to RNA and DNA sequences through comparisons to others. Work on vaccines ensued too. It closed a year ago.

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Virus DNA RNA Laboratories 82

Vial

DECEMBER 5, 2023

Transforming Genomics Research Next-generation sequencing (NGS) enables comprehensive genome sequencing and has transformed genomics research, offering vastly improved capabilities for analyzing DNA and RNA in a high-throughput and cost-effective manner. Satam et al.

Clinical Trials 52

Clinical Trials Trials RNA Bioinformatics 52

The Open Targets Blog

FEBRUARY 29, 2024

  With a background in biochemistry and bioinformatics, Lucy was interested in exploring how bioinformatics was applied to real-world healthcare data. I just graduated with a degree in Bioinformatics, and I was interested to see how the skills I learned could be applied.

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International Bioinformatics RNA Disease 59

Codon

AUGUST 27, 2024

When doctors sequenced the DNA and RNA found in Alice’s blood and synovial fluid—the liquid that surrounds and lubricates joints—they found abnormally low levels of genes encoding iron-storing proteins and high levels of epidermal growth factor receptor RNA. At least nine laboratories outside the U.S.

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DNA Hospitals Laboratories Virus 78

Drug Discovery World

NOVEMBER 13, 2023

Novel/alternative ML-enabled screening technologies for higher POS Following chairperson’s remarks from M Frank Erasmus, PhD, Head, Bioinformatics, Specifica, there will be four presentations and a panel discussion. Jana Langhoff, Tecan, on: ‘Opportunities and challenges of automating high throughput protein purification’.

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Engineering Science Bioinformatics Vaccine 148

Drug Discovery World

NOVEMBER 15, 2022

Gene-to-antibody production begins with scientists entering antibody sequences as starting material, after which bioinformatics tools filter out potentially non-viable sequences. It’s now possible to programme cell-free systems to make RNA and proteins that interact with each other,” Dr Laohakunakorn continues.

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DNA Engineering Drugs Vaccine 246

BMG Labtech

OCTOBER 4, 2023

2 DNA sequencing is also reliant on sample processing and DNA library preparation before sequencing as well as bioinformatics and data analysis after sequencing. In contrast, long-read sequencing analyzes longer strands of DNA or RNA in one go without breaking the long strands into smaller fragments.

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DNA RNA Bioinformatics Research 52

Drug Discovery World

APRIL 14, 2023

For instance, Mallick says he believes “80% of pontine gliomas have mutations in histone H3,” which in turn has a consequence on the “downstream chromatin landscape,” – a structure of DNA, RNA, histones and proteins which house the eukaryotic genome and in which mutations can lead to the development of cancers. “We BMC Bioinformatics.

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DNA Disease Bioinformatics Research 130

Broad Institute

AUGUST 11, 2022

It’s been very exciting to integrate genetics, bioinformatics, biochemistry, and structural biology approaches in one study to understand this fascinating molecular system.” Most known bacterial defense systems work by sensing viral DNA or RNA, or cellular stress due to the infection. The finding was striking and unprecedented.

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DNA Virus Immune Response Bioinformatics 52

Codon

MAY 15, 2023

Made from a Cas9 nickase (the histidine at amino acid position 840 is swapped for an alanine) fused to a reverse transcriptase enzyme (which makes DNA from RNA; transcription in reverse), prime editing clinical trials are expected to begin by 2025. link ) INSPECTR is a diagnostic tool to detect tiny amounts of viral RNA at room temperature.

DNA 52

DNA Bioinformatics Engineering Virus 52

Codon

MAY 15, 2023

Made from a Cas9 nickase (the histidine at amino acid position 840 is swapped for an alanine) fused to a reverse transcriptase enzyme (which makes DNA from RNA; transcription in reverse), prime editing clinical trials are expected to begin by 2025. link ) INSPECTR is a diagnostic tool to detect tiny amounts of viral RNA at room temperature.

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DNA Bioinformatics Engineering Virus 52

Drug Discovery World

NOVEMBER 30, 2023

She presented on how GV20 uses bioinformatics and AI to decode natural B-cell responses from large cohorts of patient tumours to uncover novel targets and antibodies simultaneously, and has brought a first-in-class antibody against a novel innate checkpoint to Ph1 clinical trial in the US.

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Protein Expression Engineering DNA Therapies 148

The Pharma Data

MARCH 20, 2021

Bioinformatics in the Faculty. Biogazelle, an innovative bioanalytical services company offering RNA and. study RNA virus replication and virus-host interactions and in particular the use of single-cell proteomics to aid in this research. Highlight #2 Professor Jo. Vandesompele is a research. also the co-founder and CSO of.

Laboratories 52

Laboratories Virus RNA Bioinformatics 52

Codon

AUGUST 10, 2023

Link A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity , by Jinek M. Link CRISPR-Cas →CRISPR-Cas: biology, mechanisms and relevance , by Hille F. & & Charpentier E. Philosophical Transactions of the Royal Society B (2016).

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DNA Cell Biology Molecular Biology Engineering 95

Codon

AUGUST 10, 2023

Link A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity , by Jinek M. Link In vitro integration of ribosomal RNA synthesis, ribosome assembly, and translation , by Jewett M.C. Link CRISPR-Cas →CRISPR-Cas: biology, mechanisms and relevance , by Hille F. & & Charpentier E.

DNA 52

DNA Cell Biology Engineering Molecular Biology 52

Codon

APRIL 16, 2023

BMC Bioinformatics. Read An RNA-based system to study hepatitis B virus replication and evaluate antivirals. Read [Comment] Delivering the next generation of cancer immunotherapies with RNA. Comparison of transformations for single-cell RNA-seq data. Read ICOR: improving codon optimization with recurrent neural networks.

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Engineering DNA RNA Science 52