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Brusatol induces ferroptosis to inhibit hepatocellular carcinoma progression by targeting ATF3

Chemical Biology and Drug Design

Using RNA-seq and through in vitro and in vivo studies, we determined that brusatol suppresses hepatocellular carcinoma progression by inducing ATF3-mediated ferroptosis. RNA sequencing (RNA-seq) and bioinformatics analyses of HCC cells were utilized to elucidate the mechanism underlying the effects of BRU in HCC.

RNA 100
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LINC00460 knockdown sensitizes cervical cancer to cisplatin by downregulating TGFBI

Chemical Biology and Drug Design

The prognostic value of long noncoding RNA (lncRNA) LINC00460 has been reported in cervical cancer. In present study, LINC00460 was screened out through bioinformatics analysis. Abstract The acquired resistance of cancer to cisplatin (DDP) limits the efficacy of chemotherapy.

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IGF2BP3 loss inhibits cell progression by upregulating has_circRNA_103820, and hsa_circRNA_103820?encoded peptide inhibits cell progression by inactivating the AKT pathway in lung cancer

Chemical Biology and Drug Design

Abstract N6-methyladenosine (m6A) modification and m6A-related RNA-binding proteins (RBPs) play vital roles in various aspects of circRNA metabolism. Moreover, bioinformatics analysis has suggested that hsa_circRNA_103820 possesses potential peptide-coding ability.

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Reaching cruising altitude: New discovery tools to target RNA

Dark Matter Blog

Our overall mission at Arrakis is to expand the set of “druggable” targets for small-molecule medicines to include RNA. Today, we are pleased to announce that our article describing one such platform: “ PEARL-seq, A Photoaffinity Platform for the Analysis of Small Molecule-RNA Interactions ” was published in ACS Chemical Biology.

RNA 52
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Identification of a 2?phenylthiazole derivative acetylcholinesterase modulator with in vitro antitumor activity in breast cancer cells

Chemical Biology and Drug Design

To clarify how A6 affected on MCF-7 cells, RNA-seq analysis was conducted to evaluate the whole genome effect of A6 on gene expression. Moreover, bioinformatic analysis and cell viability test showed A6 plays anticancer role by regulating Best1 and HIST1H2BJ. In addition, A6 induced apoptosis of MCF-7 cells.

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Malaria unravelled: decoding the parasite’s gene expression control

Drug Target Review

Through phylogenetic analysis and microscopy techniques, they identified a nuclear-encoded apicoplast RNA polymerase σ subunit called ApSigma. The initial subject of my research carrier was RNA polymerase principal sigma factors in bacteria. The first identification was based on a bioinformatic analysis.

RNA 98
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Q&A with Lucy Sibbring, an intern with the Open Targets data team

The Open Targets Blog

  With a background in biochemistry and bioinformatics, Lucy was interested in exploring how bioinformatics was applied to real-world healthcare data. I just graduated with a degree in Bioinformatics, and I was interested to see how the skills I learned could be applied.