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Genetic profiling of Lyme disease could bring new therapeutic targets 

Drug Discovery World

The study is the first to use transcriptomics as a blood test to measure RNA levels in patients with long-term Lyme disease. . As part of the study, RNA sequencing was conducted using blood samples from 152 patients with symptoms of post-treatment Lyme disease to measure their immune response. .

Disease 130
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PanOmics: Advancing drug discovery

Drug Discovery World

Using classical bulk (deep) RNA-Seq on thousands of human blood and tissue samples, Evotec has been building a high-quality molecular patient database – E.MPD. All statistical algorithms in PanHunter are peer-reviewed, ensuring that the results are trustworthy and reproducible by users with all levels of bioinformatic skills.

Drugs 130
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Malaria unravelled: decoding the parasite’s gene expression control

Drug Target Review

The results were published in Proceedings of National Academy of Sciences of United States of America (PNAS). Through phylogenetic analysis and microscopy techniques, they identified a nuclear-encoded apicoplast RNA polymerase σ subunit called ApSigma. The first identification was based on a bioinformatic analysis.

RNA 98
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Kickstarting the use of AI for biotechs: part two

Drug Target Review

2 AlphaFold 3 has been built to model DNA, RNA and smaller molecules (ligands). 5 Several major technology areas are not included above, such as cheminformatics and bioinformatics. Google DeepMind’s new AI can model DNA, RNA, and ‘all life’s molecules’. The latest exciting advancement is AlphaFold 3, which was just released.

RNA 59
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Leveraging ADCs in precision oncology strategy

Drug Target Review

Caris Life Sciences® (Caris) has been at the forefront of precision medicine. Caris Discovery, the therapeutic research arm of Caris Life Sciences, was launched to address the paucity of novel oncology drug targets and is uniquely poised to discover first-in-class ADC targets.

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Key industry partnerships advancing drug discovery

Drug Discovery World

Otsuka Pharmaceutical and Ionis Pharmaceuticals Otsuka Pharmaceutical and RNA therapy company Ionis have entered into a licence agreement for Otsuka to acquire exclusive marketing rights to Ionis’ hereditary angioedema (HAE) drug candidate donidalorsen in Europe.

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Looking ahead to AACR  

Drug Discovery World

Science ↔ Survivor Program As mentioned previously, AACR has a Scientist↔Survivor Program. These topics will be represented across a range of session types, including methods workshops, minisymposia, poster and plenary sessions, as well as keynotes, awards and lectures.