Bioinformatics, RNA and Science - Drug Discovery Digest

Reaching cruising altitude: New discovery tools to target RNA

Dark Matter Blog

AUGUST 31, 2020

Our overall mission at Arrakis is to expand the set of “druggable” targets for small-molecule medicines to include RNA. Today, we are pleased to announce that our article describing one such platform: “ PEARL-seq, A Photoaffinity Platform for the Analysis of Small Molecule-RNA Interactions ” was published in ACS Chemical Biology.

RNA

RNA Small Molecule Bioinformatics Computational Chemistry

Malaria unravelled: decoding the parasite’s gene expression control

Drug Target Review

JULY 24, 2023

The results were published in Proceedings of National Academy of Sciences of United States of America (PNAS). Through phylogenetic analysis and microscopy techniques, they identified a nuclear-encoded apicoplast RNA polymerase σ subunit called ApSigma. The first identification was based on a bioinformatic analysis.

RNA

RNA Regulations Bioinformatics Laboratories

Can Global Genomic Surveillance Forecast the Next Pandemic?

PLOS: DNA Science

MAY 16, 2024

These factors are converging to enable both identification of novel infectious diseases as well as microbial resistance, before these threats can impact public health, write a team from the European Society for Clinical Microbiology and Infectious Diseases in Frontiers in Science. Work on vaccines ensued too. It closed a year ago. .

Virus

Virus DNA RNA Laboratories

Scientific workflow for hypothesis testing in drug discovery: Part 1

Drug Target Review

DECEMBER 6, 2024

This includes verifying the experimental design and understanding how the data was generated whether it was from RNA sequencing, mass spectrometry, or other biological assays. About the authors Dr Raminderpal Singh Dr Raminderpal Singh is a recognised visionary in the implementation of AI across technology and science-focused industries.

RNA

RNA Drugs Research Science

AI At The Frontier: Empowering Early Career Professionals In Drug Discovery

Elrig

APRIL 29, 2024

With a background in Bioinformatics and Computational Biology, she has a keen interest in using technology to solve problems in healthcare and medicine. She has played a key role inbuilding the target identification platform and a proprietary database of transcriptome-wide, functional RNA structures.

Bioinformatics

Bioinformatics Drugs Molecular Biology Cell Based Assays

Kickstarting the use of AI for biotechs: part two

Drug Target Review

MAY 24, 2024

2 AlphaFold 3 has been built to model DNA, RNA and smaller molecules (ligands). 5 Several major technology areas are not included above, such as cheminformatics and bioinformatics. Google DeepMind’s new AI can model DNA, RNA, and ‘all life’s molecules’. The latest exciting advancement is AlphaFold 3, which was just released.

RNA

RNA DNA Bioinformatics Science

Leveraging ADCs in precision oncology strategy

Drug Target Review

MAY 27, 2024

Caris Life Sciences® (Caris) has been at the forefront of precision medicine. Caris Discovery, the therapeutic research arm of Caris Life Sciences, was launched to address the paucity of novel oncology drug targets and is uniquely poised to discover first-in-class ADC targets.

Clinical Trials

Clinical Trials Science Molecular Biology Bioinformatics

Tackling the Challenges of Limited Resources During a Pandemic

The Pharma Data

MARCH 20, 2021

Bioinformatics in the Faculty. of Medicine and Health Sciences (Ghent University) and. Biogazelle, an innovative bioanalytical services company offering RNA and. study RNA virus replication and virus-host interactions and in particular the use of single-cell proteomics to aid in this research. Highlight #2 Professor Jo.

Laboratories

Laboratories Virus RNA Bioinformatics

Scientists discover new antiviral defense system in bacteria

Broad Institute

AUGUST 11, 2022

The study appears in Science. It’s been very exciting to integrate genetics, bioinformatics, biochemistry, and structural biology approaches in one study to understand this fascinating molecular system.” Most known bacterial defense systems work by sensing viral DNA or RNA, or cellular stress due to the infection.

DNA

DNA Virus Immune Response Bioinformatics

Monkey Embryos Grow to 25 Days — No Womb Required

Codon

MAY 15, 2023

Every science journalist under the sun has covered this paper (though I recommend Ed Yong’s ). link ) INSPECTR is a diagnostic tool to detect tiny amounts of viral RNA at room temperature. Science Robotics. Science Robotics. Science Translational Medicine. Bioinformatics. Bioinformatics.

DNA

DNA Bioinformatics Engineering RNA

Monkey Embryos Grow to 25 Days — No Womb Required

Codon

MAY 15, 2023

Every science journalist under the sun has covered this paper (though I recommend Ed Yong’s ). link ) INSPECTR is a diagnostic tool to detect tiny amounts of viral RNA at room temperature. Science Robotics. Science Robotics. Science Translational Medicine. Bioinformatics. Bioinformatics.

DNA

DNA Bioinformatics Engineering RNA

Is That DNA Dangerous?

Codon

AUGUST 28, 2024

National Science Advisory Board for Biosecurity urged the U.S. 5 But it could match up to one of the threats in your reference database, so you opt to throw a battery of bioinformatics tools at it. BLAST is covered in every introductory bioinformatics course and the 1990 paper introducing has over 110,000 citations.

DNA

DNA Bioinformatics Virus Government

The Codon Guide to Synthetic Biology

Codon

AUGUST 10, 2023

Link A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity , by Jinek M. Science (2018). Science (2017). Science (2010). Science (2016). Science (2023). Politics and the Life Sciences (2009). Science (2014). Trends in Plant Science (2015). Science (2022).

DNA

DNA Cell Biology Molecular Biology Engineering

The Codon Guide to Synthetic Biology

Codon

AUGUST 10, 2023

Link A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity , by Jinek M. Science (2018). Science (2017). Science (2010). Science (2016). Science (2023). Politics and the Life Sciences (2009). Science (2014). & Gersbach C.A. PNAS (2008). Nature (2016).

DNA

DNA Cell Biology Engineering Molecular Biology

Codon Digest: GPT-4 Controls a Robot

Codon

APRIL 16, 2023

BMC Bioinformatics. Read Basic Science *Noncoding translation mitigation. Science Advances. Read Open science and data sharing in cognitive neuroscience with MouseBytes and MouseBytes+. Read An RNA-based system to study hepatitis B virus replication and evaluate antivirals. Science Advances. McCafferty C.L.

Engineering

Engineering DNA RNA Science

Drug Discovery Digest

Reaching cruising altitude: New discovery tools to target RNA

Malaria unravelled: decoding the parasite’s gene expression control

Trending Sources

Can Global Genomic Surveillance Forecast the Next Pandemic?

Scientific workflow for hypothesis testing in drug discovery: Part 1

AI At The Frontier: Empowering Early Career Professionals In Drug Discovery

Kickstarting the use of AI for biotechs: part two

Leveraging ADCs in precision oncology strategy

Tackling the Challenges of Limited Resources During a Pandemic

Scientists discover new antiviral defense system in bacteria

Monkey Embryos Grow to 25 Days — No Womb Required

Monkey Embryos Grow to 25 Days — No Womb Required

Is That DNA Dangerous?

The Codon Guide to Synthetic Biology

The Codon Guide to Synthetic Biology

Codon Digest: GPT-4 Controls a Robot

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