Vial

DECEMBER 5, 2023

In 2017, the Food & Drug Administration (FDA) approved the first gene therapy for cancer and for inherited diseases, the first multiplex NGS panel for companion diagnostics (CDx), and the first drug targeting a genetic signature though not a disease. Fountzilas et al. Satam et al.

Clinical Trials 52

Clinical Trials Trials RNA Bioinformatics 52

Drug Discovery World

NOVEMBER 13, 2023

Novel/alternative ML-enabled screening technologies for higher POS Following chairperson’s remarks from M Frank Erasmus, PhD, Head, Bioinformatics, Specifica, there will be four presentations and a panel discussion. Jürgen Kuball, PhD, Head, Hematology, University Medical Center Utrecht, on: ‘gdT cell inspired therapies’.

Engineering 147

Engineering Science Bioinformatics Vaccine 147

Drug Discovery World

NOVEMBER 30, 2023

CAR T cell therapies and in vivo solutions Thomas attended a presentation by Chad May, CSO of Serotiny, called: ‘Improving cell therapies with high-throughput CAR libraries’, in the session relating to optimising CARs. From a product perspective, RedShiftBio had the Aurora protein analyser with them in Lisbon this year.

Protein Expression 147

Protein Expression Engineering DNA Therapies 147

Drug Discovery World

NOVEMBER 15, 2022

Gene-to-antibody production begins with scientists entering antibody sequences as starting material, after which bioinformatics tools filter out potentially non-viable sequences. It’s now possible to programme cell-free systems to make RNA and proteins that interact with each other,” Dr Laohakunakorn continues.

DNA 246

DNA Engineering Drugs Vaccine 246

Drug Discovery World

APRIL 14, 2023

The hope is that a better understanding of the entire set of proteins (proteome) behind DIPG could help researchers develop better therapies and diagnostics for the disease. BMC Bioinformatics. To do this, Nautilus will useits protein analysis platform to provide TGen with data on the proteins involved in DPIG. Epub 2013 Jan 21.

DNA 130

DNA Disease Bioinformatics Research 130

Codon

MAY 15, 2023

Made from a Cas9 nickase (the histidine at amino acid position 840 is swapped for an alanine) fused to a reverse transcriptase enzyme (which makes DNA from RNA; transcription in reverse), prime editing clinical trials are expected to begin by 2025. link ) INSPECTR is a diagnostic tool to detect tiny amounts of viral RNA at room temperature.

DNA 52

DNA Bioinformatics Engineering Virus 52

Codon

MAY 15, 2023

Made from a Cas9 nickase (the histidine at amino acid position 840 is swapped for an alanine) fused to a reverse transcriptase enzyme (which makes DNA from RNA; transcription in reverse), prime editing clinical trials are expected to begin by 2025. link ) INSPECTR is a diagnostic tool to detect tiny amounts of viral RNA at room temperature.

DNA 52

DNA Bioinformatics Engineering Virus 52

Codon

AUGUST 10, 2023

Link A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity , by Jinek M. Link CRISPR-Cas →CRISPR-Cas: biology, mechanisms and relevance , by Hille F. & & Charpentier E. Philosophical Transactions of the Royal Society B (2016).

DNA 93

DNA Cell Biology Molecular Biology Engineering 93

Codon

AUGUST 10, 2023

Link A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity , by Jinek M. Link In vitro integration of ribosomal RNA synthesis, ribosome assembly, and translation , by Jewett M.C. Link CRISPR-Cas →CRISPR-Cas: biology, mechanisms and relevance , by Hille F. & & Charpentier E.

DNA 52

DNA Cell Biology Engineering Molecular Biology 52

Codon

APRIL 16, 2023

Compact gene editors , called enOsCas12f1 and enRhCas12f1, are smaller than many existing Cas proteins and can thus be more easily delivered in a single virus for gene therapies. BMC Bioinformatics. Read Development of a translatable gene augmentation therapy for CNGB1-Retinitis Pigmentosa. Molecular Therapy. Occelli L.M.

Engineering 52

Engineering DNA RNA Science 52