Drug Target Review

MARCH 28, 2024

Between 2000 and 2020, approximately 30 percent of the newly introduced small molecule drugs were derived from natural products. Her major focus has been untargeted metabolomics method development and bioinformatics solutions for structure elucidation. References Newman DJ, Cragg GM.

Production 128

Production Drugs Small Molecule Bioinformatics 128

Drug Discovery World

JULY 11, 2023

Much of the early AI work in the biopharmaceutical industry had been done in small molecule drug discovery due to their well-understood chemical structures and availability of large amounts of high- quality physiochemical data.

Science 100

Science Drugs FDA Engineering 100

The Pharma Data

NOVEMBER 15, 2020

R&D collaboration building on Lead Pharma’s expertise in the discovery, design and optimization of small molecule treatments. Lead Pharma may receive payments of up to €260 million plus royalties on sales. OSS, Netherlands , Nov. OSS, Netherlands , Nov.

Small Molecule 52

Small Molecule Licensing Licensing Disease 52

Drug Discovery World

AUGUST 7, 2024

Companies are already starting to collaborate on open-source software projects around managing data in areas like molecular modelling, connectivity to lab instruments, and bioinformatics code. Pre-competitive collaboration can extend even further to how AI models themselves are built.

Pharma R&D 174

Pharma R&D Clinical Trials Pharma Companies Trials 174

Drug Discovery World

APRIL 29, 2024

Jean-Baptiste Agnus, Chief Business Officer, and Peter Carbone, Chief Quality Officer, KBI Biopharma: Agnus brings more than two decades of experience in the biopharmaceutical industry with expertise in biologics, small molecule APIs, antibody-drug conjugates (ADCs), and cell and gene therapies.

Drugs 130

Drugs Small Molecule Bioinformatics Pharmaceuticals 130

Dark Matter Blog

AUGUST 31, 2020

The majority of small molecule drugs induce their therapeutic effects by seeking out and binding to their intended target while avoiding most other molecules in the dense milieu of the cell interior. Our overall mission at Arrakis is to expand the set of “druggable” targets for small-molecule medicines to include RNA.

RNA 52

RNA Small Molecule Bioinformatics Computational Chemistry 52

Nvidia Developer: Drug Discovery

DECEMBER 19, 2023

HiFi-NN annotates protein sequences with enzyme commission (EC) numbers beating the current bioinformatics tool of choice ( blastp ), as well as other SoTA DL models, including CLEAN , in precision and recall (Table 1). This platform streamlines and expedites the training of models.

Small Molecule 131

Small Molecule Science Bioinformatics Research 131

Elrig

APRIL 29, 2024

With a background in Bioinformatics and Computational Biology, she has a keen interest in using technology to solve problems in healthcare and medicine. There, I supported AI-enabled DD efforts in their small molecule portfolio. Bioinformatics is all about bringing together different areas of knowledge.

Bioinformatics 59

Bioinformatics Molecular Biology Drugs Cell Based Assays 59

Practical Cheminformatics

JANUARY 8, 2024

A Tutorial on Encoding and Generating Small Molecules with COATI [link] COATI: multi-modal contrastive pre-training for representing and traversing chemical space [link] The team at AstraZeneca released version 4 of their software package REINVENT for generative design.

Drugs 141

Drugs Small Molecule Packaging Bioinformatics 141

Drug Discovery World

NOVEMBER 13, 2023

Novel/alternative ML-enabled screening technologies for higher POS Following chairperson’s remarks from M Frank Erasmus, PhD, Head, Bioinformatics, Specifica, there will be four presentations and a panel discussion.

Engineering 148

Engineering Science Bioinformatics Vaccine 148

Codon

AUGUST 27, 2024

Extra pieces of data, including proteins, lipids, or small molecules, are helpful when a particular DNA sequence is difficult to amplify or isolate from a sample, or when sequencing results don’t point squarely at a single disease-causing organism. But DNA alone is not always enough to identify a pathogen.

DNA 78

DNA Hospitals Laboratories Virus 78

Drug Discovery World

NOVEMBER 15, 2022

Gene-to-antibody production begins with scientists entering antibody sequences as starting material, after which bioinformatics tools filter out potentially non-viable sequences. They detect specific intracellular changes or the accumulation of small molecules of interest and then translate these into measurable outputs.

DNA 246

DNA Engineering Drugs Vaccine 246

The Pharma Data

JANUARY 10, 2021

I actually think neuroscience is going to heat up in 2021,” said Ben Zeskind , co-founder and CEO of Immuneering , which is using bioinformatics and computational biology to develop new drugs in this space, along with oncology and immuno-oncology. In a boone for Slonim’s research focus, the year 2020 has made this molecule a household name.

Vaccine 52

Vaccine Regulations Disease Small Molecule 52

Codon

APRIL 16, 2023

BMC Bioinformatics. Read Aer Therapeutics, a University of California, San Francisco lab spinout developing an inhaled small molecule drug for chronic obstructive pulmonary disease, raised $36 million in a Series A. Read Deep learning of genomic contexts predicts protein co-regulation and function. McCafferty C.L. million ($1.58

Engineering 52

Engineering DNA RNA Science 52