Drug Target Review

DECEMBER 28, 2023

In most cancers, the tumour evolves by acquiring mutations that confer growth advantages or resistance to therapies. Recent advances in bioinformatics show clonal neoantigens are the best targets for immunotherapy, as I will elucidate below. This allows the cancer to evolve and develop resistance to the therapy.

Bioinformatics 105

Bioinformatics Immune Response DNA Vaccine 105

Drug Target Review

SEPTEMBER 30, 2024

Compared to traditional antibody therapies, how does the precision binding approach in your antibody design impact the therapeutic window and dosing regimen in preclinical models? Our approach represents a paradigm shift. Traditional drug discovery is based on the premise that target proteins have biological functions.

Bioinformatics 64

Bioinformatics Clinical Trials Clinical Development Treatment 64

The Premier Consulting Blog

JUNE 18, 2023

One exciting application of these technologies is the use of in silico trials in the development of novel therapies for rare diseases. As a direct consequence, in silico methods in human clinical trials are emerging as an important new paradigm in the development of medical therapies – particularly useful for rare diseases.

Drug Development 52

Drug Development Disease Clinical Trials Drugs 52

Broad Institute

AUGUST 7, 2024

At the Broad, he directs the Cancer Genome Computational Analysis Group , and he is a professor of pathology at Harvard Medical School and director of bioinformatics at Massachusetts General Hospital. She has developed innovative approaches to viral diagnostics and novel systems biology approaches to gene regulation and gene therapy.

Medical Schools 90

Medical Schools Hospitals Bioinformatics Vaccine 90

Agency IQ

OCTOBER 12, 2023

Joneckis said that CBER has “some limited uses that we have seen in external submissions, mostly in the bioinformatics area,” but not as many as CDER. Marks also offered thoughts on the “critical juncture” for gene therapies. With 15 gene therapies now approved in the U.S., With 15 gene therapies now approved in the U.S.,

FDA 40

FDA Clinical Trials International Drugs 40

Drug Target Review

JANUARY 15, 2024

Immunotherapy has become a cornerstone of cancer therapy and significantly improved patient outcomes Immunotherapy has become a cornerstone of cancer therapy and significantly improved patient outcomes The tumour regression at the metastatic site (abscopal effect) in the 4T1 tumour model is driven by CD8+ killer T cells.

Treatment 105

Treatment Immune Response Therapies Clinical Trials 105

Codon

MAY 15, 2023

This paper paves the way for off-the-shelf cell therapies that don’t require immunosuppressive drugs. link ) Administering multiple doses of lentiviral vectors (used for gene therapy) into mouse lungs is better for long-term gene expression than a single dose. Gene Therapy. Bioinformatics. Bioinformatics.

DNA 52

DNA Bioinformatics Engineering Virus 52