Bioinformatics and Vaccine - Drug Discovery Digest

Advancing vaccine design: potential of peptide mimicry

Drug Target Review

AUGUST 11, 2023

In a new development, a recent paper published in Biology Methods & Protocols by Oxford University Press has highlighted a promising avenue for enhancing vaccine efficacy against infectious pathogens like the COVID-19 virus. The implications of this finding are far-reaching, as it holds the potential to revolutionize vaccine design.

Vaccine

Vaccine Immune Response Bioinformatics Virus

A chance to design better vaccines?

SCIENMAG: Medicine & Health

JULY 24, 2023

A new paper in Biology Methods & Protocols, published by Oxford University Press, shows it may be possible to design vaccines that will induce a stronger immune response to infecting pathogens, such as the virus causing COVID-19.

Vaccine

Vaccine Bioinformatics Immune Response Virus

Not all neoantigens are created equal

Drug Target Review

DECEMBER 28, 2023

Recent advances in bioinformatics show clonal neoantigens are the best targets for immunotherapy, as I will elucidate below. Using powerful bioinformatics technology developed and validated with sequence data from the TRACERx study, researchers are able to identify clonal neoantigens from a patient’s unique tumour profile.

Bioinformatics

Bioinformatics Immune Response DNA Vaccine

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Bridging Innovation & Patient Care: The Growing Role of AI

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Six scientists named as new core institute members at Broad

Broad Institute

AUGUST 7, 2024

At the Broad, he directs the Cancer Genome Computational Analysis Group , and he is a professor of pathology at Harvard Medical School and director of bioinformatics at Massachusetts General Hospital. Gad Getz is one of the world’s leaders in cancer genomics and has pioneered widely used tools for analyzing cancer genomes.

Medical Schools

Medical Schools Hospitals Bioinformatics Vaccine

Can Global Genomic Surveillance Forecast the Next Pandemic?

PLOS: DNA Science

MAY 16, 2024

Had we grown complacent in a world freed from a list of once-deadly infectious diseases, thanks largely to vaccines and other public health measures? Work on vaccines ensued too. • identifies parts of the virus to target to provoke an immune response from a vaccine. COVID clearly caught us off guard. It closed a year ago.

Virus

Virus DNA RNA Vaccine

Transforming cancer treatment for greatest impact

Drug Target Review

JANUARY 15, 2024

N17350 has induced this immune effect in every preclinical model tested, suggesting that its therapeutic efficacy involves direct cancer-cell killing, leading to vaccine-like properties. This induced anti-tumour immunity is also detectable by increased innate and adaptive immune cells in the tumour, spleen and blood.

Treatment

Treatment Immune Response Therapies Clinical Trials

A quiet revolution in the world of proteomics

DrugBaron

NOVEMBER 22, 2022

It incorporates a number of different technological advances both in the practical LC-MS data collection and in the subsequent bioinformatic analysis developed by Methuselah Health over the last decade. This can be useful to quantify protein adducts (for example when radiolabelling a protein or preparing antigens for vaccine production).

Bioinformatics

Bioinformatics Regulations Molecular Biology Engineering

Unlocking the potential of smart antibodies

Drug Target Review

SEPTEMBER 30, 2024

Yanay is also the co-founder and chief scientific officer of Aulos, an immuno-oncology company working to revolutionise cancer care through the development of best-in-class IL-2 therapeutics, and co-founder and chairman of Ukko, a biotech company that designs and develops mRNA vaccines for the treatment of food allergies.

Bioinformatics

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WHO launches global network to detect and prevent infectious disease threats

The Pharma Data

MAY 22, 2023

With this information, scientists and public health officials can identify and track diseases to prevent and respond to outbreaks as part of a broader disease surveillance system, and to develop treatments and vaccines. COVID-19 highlighted the critical role pathogen genomics plays in responding to pandemic threats.

Disease

Disease Bioinformatics Virus Vaccine

Biopharma Executive Perspectives on 2021

The Pharma Data

JANUARY 10, 2021

When our backs were against the wall, the biotech/biopharma community came together to create not one, but two vaccines currently approved for emergency use in the U.S. Regardless of the vaccine, there are two big movements of companies that are setting their destiny to find drugs around mRNA. Moving on From the Amyloid Hypothesis. “I

Vaccine

Vaccine Disease Regulations Small Molecule

Defense-Forward Biosecurity

Codon

AUGUST 27, 2024

New Yorkers wait to receive a monkeypox vaccine. These laboratories share data and bioinformatics tools that enabled the early detection of SARS-CoV-2 and monkeypox even before their reference genomes were available. When an anomaly is detected, a technician comes to remove the filter and analyze the data.

DNA

DNA Laboratories Hospitals Virus

In Silico Modeling Unveils a New Era in Rare Disease Drug Development

The Premier Consulting Blog

JUNE 18, 2023

The information gleaned from these in silico models was used to design and test medicines against the virus, speed-up the vaccine discovery pipeline, predict any therapeutic failures, and minimize undesired effects. BMC Bioinformatics 2020, 21(Suppl 17):527 [link] Accessed April 4, 2023, at: [link] [2] Russo et al.

Drug Development

Drug Development Disease Clinical Trials Drugs

Tackling the Challenges of Limited Resources During a Pandemic

The Pharma Data

MARCH 20, 2021

Bioinformatics in the Faculty. effective SARS-CoV-2 vaccine continues to attract. The MANTIS. liquid handler has also been pivotal. in reducing assay volumes, providing significant cost savings, and again helping to avoid. delays where reagents are in. short supply. Highlight #2 Professor Jo. Vandesompele is a research.

Laboratories

Laboratories Virus RNA Bioinformatics

Monkey Embryos Grow to 25 Days — No Womb Required

Codon

MAY 15, 2023

link ) A phase I trial of a personalized neoantigen vaccine showed that they could boost T-cells and help fight off pancreatic tumors. Bioinformatics. Bioinformatics. Nature Communications. link ) ( Commentary ) 💾 Computers x Bio Papers from the worlds of AI & software. Nucleic Acids Research.

DNA

DNA Bioinformatics Engineering Virus

Monkey Embryos Grow to 25 Days — No Womb Required

Codon

MAY 15, 2023

link ) A phase I trial of a personalized neoantigen vaccine showed that they could boost T-cells and help fight off pancreatic tumors. Bioinformatics. Bioinformatics. Nature Communications. link ) ( Commentary ) 💾 Computers x Bio Papers from the worlds of AI & software. Nucleic Acids Research.

DNA

DNA Bioinformatics Engineering Virus

Article FDA Thank You Leaders at FDA share highlights and updates for drugs and biologics at RAPS Convergence

Agency IQ

OCTOBER 12, 2023

Joneckis said that CBER has “some limited uses that we have seen in external submissions, mostly in the bioinformatics area,” but not as many as CDER. Regarding artificial intelligence (AI), an important topic at RAPS Convergence, the two centers discussed external and internal use cases.

FDA

FDA Clinical Trials International Drugs

Is That DNA Dangerous?

Codon

AUGUST 28, 2024

The Japanese cult Aum Shinrikyo, for example, tried to combine two vaccine strains of Bacillus anthracis to produce an anthrax bioweapon, according to interviews conducted several years later. 5 But it could match up to one of the threats in your reference database, so you opt to throw a battery of bioinformatics tools at it.

DNA

DNA Bioinformatics Virus Government

Bristol Myers Squibb Announces Interim Results from Long-Term Study Reinforcing Efficacy and Safety Profile of Zeposia (ozanimod) in Patients with Relapsing Forms of Multiple Sclerosis

The Pharma Data

SEPTEMBER 1, 2020

Presentation Topic: Biomarkers and Bioinformatics. Patients without a healthcare professional-confirmed history of varicella (chickenpox), or without documentation of a full course of vaccination against varicella zoster virus (VZV), should be tested for antibodies to VZV before initiating ZEPOSIA. Author: Harris. Author: Healy.

Clinical Trials

Clinical Trials Treatment Trials Disease

Codon Digest: GPT-4 Controls a Robot

Codon

APRIL 16, 2023

BMC Bioinformatics. Read The T-cell-directed vaccine BNT162b4 encoding conserved non-spike antigens protects animals from severe SARS-CoV-2 infection. Read Effectiveness of a bivalent mRNA vaccine booster dose to prevent severe COVID-19 outcomes: a retrospective cohort study. McCafferty C.L. Molecular Therapy. Arieta C.M.

Engineering

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