Bioinformatics, Vaccine and Virus - Drug Discovery Digest

Advancing vaccine design: potential of peptide mimicry

Drug Target Review

AUGUST 11, 2023

In a new development, a recent paper published in Biology Methods & Protocols by Oxford University Press has highlighted a promising avenue for enhancing vaccine efficacy against infectious pathogens like the COVID-19 virus. Since December 2019, SARS-CoV-2 (COVID-19) infection has become a worldwide urgent public health concern.

Vaccine

Vaccine Immune Response Bioinformatics Virus

A chance to design better vaccines?

SCIENMAG: Medicine & Health

JULY 24, 2023

A new paper in Biology Methods & Protocols, published by Oxford University Press, shows it may be possible to design vaccines that will induce a stronger immune response to infecting pathogens, such as the virus causing COVID-19.

Vaccine

Vaccine Bioinformatics Immune Response Virus

Not all neoantigens are created equal

Drug Target Review

DECEMBER 28, 2023

Recent advances in bioinformatics show clonal neoantigens are the best targets for immunotherapy, as I will elucidate below. Using powerful bioinformatics technology developed and validated with sequence data from the TRACERx study, researchers are able to identify clonal neoantigens from a patient’s unique tumour profile.

Bioinformatics

Bioinformatics Immune Response DNA Vaccine

Webinars

Bridging Innovation & Patient Care: The Growing Role of AI

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Can Global Genomic Surveillance Forecast the Next Pandemic?

PLOS: DNA Science

MAY 16, 2024

Had we grown complacent in a world freed from a list of once-deadly infectious diseases, thanks largely to vaccines and other public health measures? A Novel Virus Appears In retrospect, everything unfolded with astonishing speed. Work on vaccines ensued too. COVID clearly caught us off guard. It closed a year ago.

Virus

Virus DNA RNA Vaccine

Defense-Forward Biosecurity

Codon

AUGUST 27, 2024

While reading all the sequences present in a sample, researchers want to find any that are out of place, such as those that belong to a never-before-seen virus. New Yorkers wait to receive a monkeypox vaccine. This cleaning, annotation, and characterization work is all performed computationally.

DNA

DNA Laboratories Hospitals Virus

WHO launches global network to detect and prevent infectious disease threats

The Pharma Data

MAY 22, 2023

With this information, scientists and public health officials can identify and track diseases to prevent and respond to outbreaks as part of a broader disease surveillance system, and to develop treatments and vaccines. New, more transmissible variants of the virus would not have been as quickly identified.

Disease

Disease Bioinformatics Virus Vaccine

Tackling the Challenges of Limited Resources During a Pandemic

The Pharma Data

MARCH 20, 2021

Bioinformatics in the Faculty. Ghent University Hospital for SARS-CoV-2 virus screening. study RNA virus replication and virus-host interactions and in particular the use of single-cell proteomics to aid in this research. effective SARS-CoV-2 vaccine continues to attract. The MANTIS. delays where reagents are in.

Laboratories

Laboratories Virus RNA Bioinformatics

In Silico Modeling Unveils a New Era in Rare Disease Drug Development

The Premier Consulting Blog

JUNE 18, 2023

The information gleaned from these in silico models was used to design and test medicines against the virus, speed-up the vaccine discovery pipeline, predict any therapeutic failures, and minimize undesired effects. BMC Bioinformatics 2020, 21(Suppl 17):527 [link] Accessed April 4, 2023, at: [link] [2] Russo et al.

Drug Development

Drug Development Disease Clinical Trials Drugs

Monkey Embryos Grow to 25 Days — No Womb Required

Codon

MAY 15, 2023

link ) A phase I trial of a personalized neoantigen vaccine showed that they could boost T-cells and help fight off pancreatic tumors. Bioinformatics. Bioinformatics. This means that there’s no need to deliver the proteins at all; they are already lurking in the genome. Nature Communications. grams per liter titer.

DNA

DNA Bioinformatics Engineering Virus

Monkey Embryos Grow to 25 Days — No Womb Required

Codon

MAY 15, 2023

link ) A phase I trial of a personalized neoantigen vaccine showed that they could boost T-cells and help fight off pancreatic tumors. Bioinformatics. Bioinformatics. This means that there’s no need to deliver the proteins at all; they are already lurking in the genome. Nature Communications. grams per liter titer.

DNA

DNA Bioinformatics Engineering Virus

Is That DNA Dangerous?

Codon

AUGUST 28, 2024

The Japanese cult Aum Shinrikyo, for example, tried to combine two vaccine strains of Bacillus anthracis to produce an anthrax bioweapon, according to interviews conducted several years later. It wasn’t illegal, however, for Harris to order the vials of deadly bacteria that Ohio police officers later found in his car.

DNA

DNA Bioinformatics Virus Government

Codon Digest: GPT-4 Controls a Robot

Codon

APRIL 16, 2023

Compact gene editors , called enOsCas12f1 and enRhCas12f1, are smaller than many existing Cas proteins and can thus be more easily delivered in a single virus for gene therapies. BMC Bioinformatics. Read The T-cell-directed vaccine BNT162b4 encoding conserved non-spike antigens protects animals from severe SARS-CoV-2 infection.

Engineering

Engineering DNA RNA Science

Bristol Myers Squibb Announces Interim Results from Long-Term Study Reinforcing Efficacy and Safety Profile of Zeposia (ozanimod) in Patients with Relapsing Forms of Multiple Sclerosis

The Pharma Data

SEPTEMBER 1, 2020

Presentation Topic: Biomarkers and Bioinformatics. Patients without a healthcare professional-confirmed history of varicella (chickenpox), or without documentation of a full course of vaccination against varicella zoster virus (VZV), should be tested for antibodies to VZV before initiating ZEPOSIA. Author: Harris. Author: Healy.

Treatment

Treatment Clinical Trials Trials Disease

Drug Discovery Digest

Advancing vaccine design: potential of peptide mimicry

A chance to design better vaccines?

Webinars

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Not all neoantigens are created equal

Webinars

Can Global Genomic Surveillance Forecast the Next Pandemic?

Defense-Forward Biosecurity

WHO launches global network to detect and prevent infectious disease threats

Tackling the Challenges of Limited Resources During a Pandemic

In Silico Modeling Unveils a New Era in Rare Disease Drug Development

Monkey Embryos Grow to 25 Days — No Womb Required

Monkey Embryos Grow to 25 Days — No Womb Required

Is That DNA Dangerous?

Codon Digest: GPT-4 Controls a Robot

Bristol Myers Squibb Announces Interim Results from Long-Term Study Reinforcing Efficacy and Safety Profile of Zeposia (ozanimod) in Patients with Relapsing Forms of Multiple Sclerosis

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