Bioinformatics and Virus - Drug Discovery Digest

Advancing vaccine design: potential of peptide mimicry

Drug Target Review

AUGUST 11, 2023

In a new development, a recent paper published in Biology Methods & Protocols by Oxford University Press has highlighted a promising avenue for enhancing vaccine efficacy against infectious pathogens like the COVID-19 virus. The role of extracellular vesicles in COVID-19 virus infection [Internet].

Vaccine

Vaccine Immune Response Bioinformatics Virus

A chance to design better vaccines?

SCIENMAG: Medicine & Health

JULY 24, 2023

A new paper in Biology Methods & Protocols, published by Oxford University Press, shows it may be possible to design vaccines that will induce a stronger immune response to infecting pathogens, such as the virus causing COVID-19.

Vaccine

Vaccine Bioinformatics Immune Response Virus

Finding the right CDMO partner for cell line development

Drug Target Review

APRIL 5, 2024

Finally, comprehensive genetic knowledge also facilitates the use of powerful bioinformatic tools that strengthen the cell-line development process, especially for enhanced protein expression or monoclonality assessment. The first concern is microbial contamination.

Protein Production

Protein Production Protein Expression Bioinformatics Production

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Q&A: How Terra became a backbone of public health pathogen surveillance

Broad Institute

SEPTEMBER 30, 2024

BM: During COVID, there was an exponential increase in the need to analyze pathogen genomic data in public health settings quickly, locally, and often without deep bioinformatics capacity. Terra was one of the few systems that was available and ready to meet the moment.

Bioinformatics

Bioinformatics Disease Engineering Virus

A new viral surveillance system in West Africa is showing the world how to prevent the next pandemic

Broad Institute

APRIL 25, 2024

The Sentinel team has also trained more than 1,600 scientists from all 54 African countries in genomics, diagnostics, and bioinformatics. It can take only 36 hours for a virus that is emerging in a very remote place to find itself in New York or Paris — they are just a few flights away,” Happi said.

Virus

Virus Hospitals Disease Government

Scientists discover new antiviral defense system in bacteria

Broad Institute

AUGUST 11, 2022

It’s been very exciting to integrate genetics, bioinformatics, biochemistry, and structural biology approaches in one study to understand this fascinating molecular system.” These bacterial proteins were instead directly sensing key parts of the virus. The cells underwent a dramatic defensive response and survived.

DNA

DNA Virus Immune Response Bioinformatics

Not all neoantigens are created equal

Drug Target Review

DECEMBER 28, 2023

Recent advances in bioinformatics show clonal neoantigens are the best targets for immunotherapy, as I will elucidate below. Using powerful bioinformatics technology developed and validated with sequence data from the TRACERx study, researchers are able to identify clonal neoantigens from a patient’s unique tumour profile.

Bioinformatics

Bioinformatics Immune Response DNA Vaccine

In Silico Modeling Unveils a New Era in Rare Disease Drug Development

The Premier Consulting Blog

JUNE 18, 2023

The information gleaned from these in silico models was used to design and test medicines against the virus, speed-up the vaccine discovery pipeline, predict any therapeutic failures, and minimize undesired effects. BMC Bioinformatics 2020, 21(Suppl 17):527 [link] Accessed April 4, 2023, at: [link] [2] Russo et al.

Drug Development

Drug Development Disease Clinical Trials Drugs

Defense-Forward Biosecurity

Codon

AUGUST 27, 2024

While reading all the sequences present in a sample, researchers want to find any that are out of place, such as those that belong to a never-before-seen virus. These laboratories share data and bioinformatics tools that enabled the early detection of SARS-CoV-2 and monkeypox even before their reference genomes were available.

DNA

DNA Laboratories Hospitals Virus

Monkey Embryos Grow to 25 Days — No Womb Required

Codon

MAY 15, 2023

Bioinformatics. Bioinformatics. This means that there’s no need to deliver the proteins at all; they are already lurking in the genome. And a third study shows that prime editors can be split up and delivered into cells via two separate viruses. Nature Communications. grams per liter titer. coli infections and eradicate biofilms.

DNA

DNA Bioinformatics Engineering Virus

Monkey Embryos Grow to 25 Days — No Womb Required

Codon

MAY 15, 2023

Bioinformatics. Bioinformatics. This means that there’s no need to deliver the proteins at all; they are already lurking in the genome. And a third study shows that prime editors can be split up and delivered into cells via two separate viruses. Nature Communications. grams per liter titer. coli infections and eradicate biofilms.

DNA

DNA Bioinformatics Engineering Virus

Can Global Genomic Surveillance Forecast the Next Pandemic?

PLOS: DNA Science

MAY 16, 2024

A Novel Virus Appears In retrospect, everything unfolded with astonishing speed. Did it there either recombine with another virus on its own, or inspire a manipulation of another virus of a key part of the spike gene, seeding the pandemic through a “lab leak?” Work on vaccines ensued too. It closed a year ago.

Virus

Virus DNA RNA Vaccine

Tackling the Challenges of Limited Resources During a Pandemic

The Pharma Data

MARCH 20, 2021

Bioinformatics in the Faculty. Ghent University Hospital for SARS-CoV-2 virus screening. study RNA virus replication and virus-host interactions and in particular the use of single-cell proteomics to aid in this research. The MANTIS. liquid handler has also been pivotal. delays where reagents are in. short supply.

Laboratories

Laboratories Virus RNA Bioinformatics

WHO launches global network to detect and prevent infectious disease threats

The Pharma Data

MAY 22, 2023

New, more transmissible variants of the virus would not have been as quickly identified. Argentina is deeply invested in building our own country capacity in pathogen genomics and the capacity of other countries,” said Josefina Campos, Director of the National Genomics and Bioinformatics Center at ANLIS Malbrán, Argentina.

Disease

Disease Bioinformatics Virus Vaccine

Codon Digest: GPT-4 Controls a Robot

Codon

APRIL 16, 2023

Compact gene editors , called enOsCas12f1 and enRhCas12f1, are smaller than many existing Cas proteins and can thus be more easily delivered in a single virus for gene therapies. BMC Bioinformatics. Read An RNA-based system to study hepatitis B virus replication and evaluate antivirals. McCafferty C.L. Nature Communications.

Engineering

Engineering DNA RNA Science

Early evidence and emerging trends: How AI is shaping drug discovery and clinical development

Drug Target Review

APRIL 11, 2025

During the COVID-19 pandemic, BenevolentAI used its AI platform to identify baricitinib as a potential treatment for the virus in just three days, an impressive example of rapid repurposing of existing drugs. Recently Recursion Pharmaceuticals unbiased, machine learning-powered genomics screen rapidly identified and advanced REC-1245.

Clinical Development

Clinical Development Drugs Pharmaceuticals Clinical Trials

Is That DNA Dangerous?

Codon

AUGUST 28, 2024

It is relatively straightforward to detect the first threat―creating a virus from scratch using synthetic DNA—by searching for small fragments of known viral DNA sequences in a customer’s order. This incident spurred new laws to restrict the sale of bacteria or viruses. Journalists gather outside No.

DNA

DNA Bioinformatics Virus Government

Bristol Myers Squibb Announces Interim Results from Long-Term Study Reinforcing Efficacy and Safety Profile of Zeposia (ozanimod) in Patients with Relapsing Forms of Multiple Sclerosis

The Pharma Data

SEPTEMBER 1, 2020

Presentation Topic: Biomarkers and Bioinformatics. Patients without a healthcare professional-confirmed history of varicella (chickenpox), or without documentation of a full course of vaccination against varicella zoster virus (VZV), should be tested for antibodies to VZV before initiating ZEPOSIA. Author: Harris. Author: Healy.

Clinical Trials

Clinical Trials Treatment Trials Disease

Drug Discovery Digest

Advancing vaccine design: potential of peptide mimicry

A chance to design better vaccines?

Webinars

Trending Sources

Finding the right CDMO partner for cell line development

Webinars

Q&A: How Terra became a backbone of public health pathogen surveillance

A new viral surveillance system in West Africa is showing the world how to prevent the next pandemic

Scientists discover new antiviral defense system in bacteria

Not all neoantigens are created equal

In Silico Modeling Unveils a New Era in Rare Disease Drug Development

Defense-Forward Biosecurity

Monkey Embryos Grow to 25 Days — No Womb Required

Monkey Embryos Grow to 25 Days — No Womb Required

Can Global Genomic Surveillance Forecast the Next Pandemic?

Tackling the Challenges of Limited Resources During a Pandemic

WHO launches global network to detect and prevent infectious disease threats

Codon Digest: GPT-4 Controls a Robot

Early evidence and emerging trends: How AI is shaping drug discovery and clinical development

Is That DNA Dangerous?

Bristol Myers Squibb Announces Interim Results from Long-Term Study Reinforcing Efficacy and Safety Profile of Zeposia (ozanimod) in Patients with Relapsing Forms of Multiple Sclerosis

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