Covalent Modifiers

FEBRUARY 10, 2025

Using different biophysical assays, the stabilizing potency of the imine-bond forming molecules was mapped and X-ray crystallography studies provided structural data on the binding mode of the ternary complexes.

Biophysical Assays 173

Biophysical Assays Small Molecule Engineering Regulations 173

Covalent Modifiers

FEBRUARY 1, 2024

Taken together, the protein bioconjugation toolkit that we disclose herein will contribute towards the generation of both mono and multi-labelled protein-small molecule bioconjugates for applications as diverse as biophysical assays, cellular imaging, and the production of therapeutic protein–drug conjugates.

Biophysical Assays 200

Biophysical Assays Small Molecule Drug Development Production 200

Covalent Modifiers

SEPTEMBER 9, 2023

Orthogonal biophysical assays, including mass spectrometry and fluorescence anisotropy, were used to establish structure–activity relationships. Here, we show the structure-based optimization of the nonselective fragment toward selective and highly potent small-molecule stabilizers of the 14-3-3σ/ERα complex.

Small Molecule 200

Small Molecule Biophysical Assays Production Drugs 200

Sygnature Discovery

JUNE 17, 2024

Comprehensive Assay Development for Diverse Applications Our team here at Sygnature Discovery, comprised of expert biophysicists, is highly experienced in a variety of target classes and drug modalities. Sygnature Discovery’s Biophysical Assay Development Capabilities: 1.

Biophysical Assays 52

Biophysical Assays Screening Hits Assay Development Fragment Screening 52

Zobio

DECEMBER 7, 2023

Biochemical assays are commonly used to assess how organic compounds impact the activity of a protein of interest (POI).

Biochemical Assays 40

Biochemical Assays Biophysical Assays Drugs 40

Drug Target Review

NOVEMBER 1, 2023

In 2007 Dr van Montfort joined the Institute of Cancer Research (London, UK), where he holds a joint position between the Centre for Cancer Drug Discovery (CCDD) and the Division of Structural Biology.

Fragment Screening 96

Fragment Screening Biochemical Assays Small Molecule Biophysical Assays 96

Molecular Design

SEPTEMBER 18, 2024

When examining differences between IC 50 values for the same combination of target and inhibitor it's worth bearing in mind that interference with assay read-outs tends to be more of an issue at high concentration (this is why biophysical assays tend to be favored for screening fragments).

Biochemical Assays 68

Biochemical Assays Biophysical Assays Drugs Cell Based Assays 68