Biophysical Assays and Drug Development

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Biophysical Assays

Drug Development

Location-agnostic site-specific protein bioconjugation via Baylis Hillman adducts

Covalent Modifiers

FEBRUARY 1, 2024

link] Proteins labelled site-specifically with small molecules are valuable assets for chemical biology and drug development. Nat Commun 15 , 859 (2024). The unique reactivity profile of the 1,2-aminothiol moiety of N -terminal cysteines ( N -Cys) of proteins renders it highly attractive for regioselective protein labelling.

Biophysical Assays

Biophysical Assays Small Molecule Drug Development Production

Target-directed cancer: protein-ligand interactions

Drug Target Review

NOVEMBER 1, 2023

In 2007 Dr van Montfort joined the Institute of Cancer Research (London, UK), where he holds a joint position between the Centre for Cancer Drug Discovery (CCDD) and the Division of Structural Biology. In 2019 he became Reader in Structural Biology and Cancer Drug Discovery.

Fragment Screening

Fragment Screening Biochemical Assays Small Molecule Biophysical Assays

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Location-agnostic site-specific protein bioconjugation via Baylis Hillman adducts

Target-directed cancer: protein-ligand interactions

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