Biophysical Assays, Drug Development and Drugs

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Biophysical Assays

Drug Development

Drugs

Location-agnostic site-specific protein bioconjugation via Baylis Hillman adducts

Covalent Modifiers

FEBRUARY 1, 2024

link] Proteins labelled site-specifically with small molecules are valuable assets for chemical biology and drug development. Nat Commun 15 , 859 (2024). The unique reactivity profile of the 1,2-aminothiol moiety of N -terminal cysteines ( N -Cys) of proteins renders it highly attractive for regioselective protein labelling.

Biophysical Assays

Biophysical Assays Small Molecule Drug Development Production

Target-directed cancer: protein-ligand interactions

Drug Target Review

NOVEMBER 1, 2023

Could you provide an overview of your research on target directed cancer drug discovery, particularly your focus on protein lagging interactions. I work in the Centre for Cancer Drug Discovery (CCDD) at The Institute of Cancer Research in London, which is an academic drug discovery centre. 2013) 56, 2059-2073.

Fragment Screening

Fragment Screening Biochemical Assays Small Molecule Biophysical Assays

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Location-agnostic site-specific protein bioconjugation via Baylis Hillman adducts

Target-directed cancer: protein-ligand interactions

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