Biophysical Assays and Engineering - Drug Discovery Digest

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Biophysical Assays

Engineering

Site-Specific Molecular Glues for the 14-3-3/Tau pS214 ProteinProtein Interaction via Reversible Covalent Imine Tethering

Covalent Modifiers

FEBRUARY 10, 2025

Using different biophysical assays, the stabilizing potency of the imine-bond forming molecules was mapped and X-ray crystallography studies provided structural data on the binding mode of the ternary complexes.

Biophysical Assays

Biophysical Assays Small Molecule Engineering Regulations

Obstacles and innovations of macrocyclic drug development

Drug Target Review

JANUARY 16, 2025

11 Macrocycles can also be engineered in other ways to become more cell permeable; for example, by incorporating N-methyl groups in macrocyclic peptides. 12 Ring bridging strategies have also been effective in addressing permeability, as seen with MK-0616.

Drug Development

Drug Development Small Molecule Drugs FDA Approval

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Site-Specific Molecular Glues for the 14-3-3/Tau pS214 ProteinProtein Interaction via Reversible Covalent Imine Tethering

Obstacles and innovations of macrocyclic drug development

Webinars

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