Remove Biophysical Assays Remove Fragment Screening Remove Science
article thumbnail

Advancements in hit identification for membrane protein drug discovery

Drug Target Review

This stability enables the application of hit identification approaches such as fragment-based screening (FBS). The development of PoLiPa technology marks a new era in membrane protein drug discovery, rendering otherwise difficult targets accessible to structural biology, biophysical assays and other screening technologies.

article thumbnail

Target-directed cancer: protein-ligand interactions  

Drug Target Review

In terms of compound libraries, we have a high-throughput screening library of about 200,000 ligands. For fragment screening, which are much smaller compounds, we have a library of about 3000 fragments. We can screen with many different formats and modalities.