Sygnature Discovery

JUNE 17, 2024

From hit finding and target engagement studies, to the characterisation of kinetic properties for late-stage candidate molecules, we believe that a biophysical approach complements other assays to deliver a fuller picture of binding behaviour to produce more effective therapeutics.

Biophysical Assays 52

Biophysical Assays Screening Hits Fragment Screening Assay Development 52

Drug Target Review

NOVEMBER 1, 2023

The mission of the CCDD is to discover novel small-molecule therapeutics for the treatment of cancer and progress them to hypothesis testing phase 1 clinical trials. We have several exciting projects in various stages of discovery, but a small-molecule drug that is causing a lot of excitement at the moment is Capivasertib.

Fragment Screening 96

Fragment Screening Biochemical Assays Small Molecule Biophysical Assays 96

Drug Discovery World

AUGUST 9, 2024

The SAMDI technology is amenable to any buffer component, encouraging the optimisation of the assay based on the biological needs of the target. “Affinity selection MS (ASMS) to identify small molecule binders to protein, oligonucleotide, and cellular targets, is promising,” Gurard-Levin adds.

Biophysical Assays 147

Biophysical Assays Small Molecule Drugs DNA 147