Drug Target Review

APRIL 7, 2025

2 Considering 2530 percent of marketed drugs work by binding to GPCRs, 3 it is vital that these challenges are overcome through innovation and research. This crucial role in regulating vital bodily processes makes it a highly important drug target within GPCR research.

Fragment Screening 52

Fragment Screening Drugs Small Molecule Biophysical Assays 52

Drug Target Review

NOVEMBER 1, 2023

Could you provide an overview of your research on target directed cancer drug discovery, particularly your focus on protein lagging interactions. I work in the Centre for Cancer Drug Discovery (CCDD) at The Institute of Cancer Research in London, which is an academic drug discovery centre. Acta Cryst. Acta Cryst. 2013) 56, 2059-2073.

Fragment Screening 96

Fragment Screening Biochemical Assays Small Molecule Biophysical Assays 96

Drug Target Review

JANUARY 16, 2025

3 Antibodies are primarily used to target extracellular proteins, though researchers have generated antibodies that can reach intracellular targets. However, research has shown that constrained cyclic peptides, like macrocycles, are often more stable than non-cyclic peptides. Accounts of Chemical Research , 54(18):36043617, 2021.

Drug Development 52

Drug Development Small Molecule Drugs FDA Approval 52