Biophysical Assays, Science and Screening Hits

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Biophysical Assays

Science

Screening Hits

Advancements in hit identification for membrane protein drug discovery

Drug Target Review

APRIL 7, 2025

Advancements in screening technologies for small-molecule drug discovery including cellular assays, computational screening, and biophysics-based methods enhanced by structural biology breakthroughs have improved screening hit rates and facilitated the identification of drug candidates for previously undruggable targets.

Fragment Screening

Fragment Screening Drugs Small Molecule Biophysical Assays

Target-directed cancer: protein-ligand interactions

Drug Target Review

NOVEMBER 1, 2023

So that is a wide range of techniques to look at the protein-ligand interactions, all with the aim to guide the optimisation of our first screening hits to potent inhibitors that hopefully are cell-active at some point. You need to be resilient because science is difficult and things will fail.

Fragment Screening

Fragment Screening Biochemical Assays Small Molecule Biophysical Assays

Webinars

Bridging Innovation & Patient Care: The Growing Role of AI

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Drug Discovery Digest

Advancements in hit identification for membrane protein drug discovery

Target-directed cancer: protein-ligand interactions

Webinars

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