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Expanding Your Assay Specificity: Cisbio Joins PerkinElmer

PerkinElmer

The structure of HTRF reagents also makes assays highly resistant to most experimental conditions, and particularly well suited for cell-based assays. The post Expanding Your Assay Specificity: Cisbio Joins PerkinElmer first appeared on PerkinElmer Blog. Learn more about Cisbio here.

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Atherosclerotic vascular disease | BMG LABTECH

BMG Labtech

In this blog, we highlight some of the solutions available for researchers to tackle atherosclerotic vascular disease: from fundamental research rooted in ischemia-reperfusion studies and cell-based assays to drug discovery efforts and the early detection of drug-related side effects.

Disease 52
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Use of Ultra-High-Throughput Screening in Discovery of COVID-19 Virus Structure

PerkinElmer

Following the high-throughput screening were cell-based assays, which demonstrated that the identified leads had strong anti-viral action. Sources [link] [link] The post Use of Ultra-High-Throughput Screening in Discovery of COVID-19 Virus Structure first appeared on PerkinElmer Blog.

Virus 52
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On the misuse of chemical probes

Molecular Design

It’s now time to get back to chemical probes and I’ll be taking a look at S2023 (Systematic literature review reveals suboptimal use of chemical probes in cell-based biomedical research) which has already been reviewed in blog posts from Practical Fragments , In The Pipeline and the Institute of Cancer Research.

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Data checks

The ChEMBL-og

ChEMBL contains a broad range of binding, functional and ADMET type assays in formats ranging from in vitro single protein assays to anti proliferative cell-based assays. Some variation is expected, even for very similar assays, since these are often performed by different groups and institutes.

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Assays for the Future of Drug Discovery

PerkinElmer

Download the whitepaper to learn more about cell-based assays and what to consider as you design yours. The post Assays for the Future of Drug Discovery first appeared on PerkinElmer Blog. By assessing residence time, failure further down the drug discovery workflow can be avoided.

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Archbishop Ussher's guide to efficient selection of development candidates

Molecular Design

As the start of the post, I did mention some errors that you don’t want to be making if cheminformatics is your day job and regular readers of this blog will have already guessed that I’m talking about ligand efficiency (LE).