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Expanding Your Assay Specificity: Cisbio Joins PerkinElmer

PerkinElmer

Over the last 20 years, Cisbio has become a leading Life Sciences company which develops, manufactures, and markets high quality kits and reagents for the drug discovery and life science markets used by pharmaceutical, biotechnology, academia and contract research organizations across the globe. Learn more about Cisbio here.

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Chemical con artists foil drug discovery

Molecular Design

BW2014 has been heavily cited in the drug discovery literature (it was cited as the first reference in the ACS assay interference editorial which I reviewed in K2017 ) despite providing nothing in the way of practical advice for dealing with nuisance behavior. Given that M2003 had been published over a decade previously.

Drugs 96
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Assays for the Future of Drug Discovery

PerkinElmer

Drug discovery is always evolving. From new processes to advanced technologies, excellence in drug discovery is the result of combining different approaches. Emerging and Resurrecting Technologies We’ve made huge strides in the drug discovery process, and it’s only getting better as we move forward.

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Atherosclerotic vascular disease | BMG LABTECH

BMG Labtech

In this blog, we highlight some of the solutions available for researchers to tackle atherosclerotic vascular disease: from fundamental research rooted in ischemia-reperfusion studies and cell-based assays to drug discovery efforts and the early detection of drug-related side effects.

Disease 52
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Use of Ultra-High-Throughput Screening in Discovery of COVID-19 Virus Structure

PerkinElmer

COVID-19’s Main Viral Protease Identified as Target More Than 10,000 Compounds Quickly Assayed Using computer-aided drug design, the Shanghai-based team identified an inhibitor of M pro , called N3. They then visualized not only the crystal structure of the SARS-CoV-2 virus, but also N3 in complex with SARS-CoV-2.

Virus 52
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On the misuse of chemical probes

Molecular Design

It’s now time to get back to chemical probes and I’ll be taking a look at S2023 (Systematic literature review reveals suboptimal use of chemical probes in cell-based biomedical research) which has already been reviewed in blog posts from Practical Fragments , In The Pipeline and the Institute of Cancer Research.

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Data checks

The ChEMBL-og

ChEMBL contains a broad range of binding, functional and ADMET type assays in formats ranging from in vitro single protein assays to anti proliferative cell-based assays. Some variation is expected, even for very similar assays, since these are often performed by different groups and institutes.