PerkinElmer

SEPTEMBER 8, 2019

The structure of HTRF reagents also makes assays highly resistant to most experimental conditions, and particularly well suited for cell-based assays. The post Expanding Your Assay Specificity: Cisbio Joins PerkinElmer first appeared on PerkinElmer Blog. Learn more about Cisbio here.

Cell Based Assays 52

Cell Based Assays Small Molecule Science Pharmaceuticals 52

PerkinElmer

JANUARY 7, 2020

Here are two predictions for the future: Alpha CETSA ® for target engagement While traditional assay methods detect either the displacement of a radioligand binding to the target by a competitor molecule, or the modulation of some function of the target, a new method is making headway: Cellular Thermo Shift Assay (CETSA) from Pelago Bioscience.

Small Molecule 52

Small Molecule Cell Based Assays Drugs Drug Development 52

Molecular Design

JUNE 8, 2023

Nevertheless, those small molecule drug properties that show consistent differentiation from their target compounds over time, namely, potency, ligand efficiencies (LE and LLE), and the aromatic ring count and lipophilicity of carboaromatic drugs, are those that are most likely to remain future-proof.

Cell Based Assays 62

Cell Based Assays Small Molecule Drugs Marketing 62

Molecular Design

DECEMBER 31, 2023

The effects of curcumin, EGCG (epigallocatechin gallate), genistein and resveratrol on four membrane proteins were reported in Ref9 and these effects would raise doubts about activity for any of these compounds (or their close structural analogs) that had been observed in a cell-based assay.

Drugs 96

Drugs Packaging Cell Based Assays Small Molecule 96