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Effectors of signal transmission events Second messengers are small molecules or ions that transmit signals received at the cell surface to the inside environment of the cell (Fig.
They did it using cryo-electron microscopy (cryo-EM), a groundbreaking technique featured several times here on my blog. That includes those involved in regulating our appetites and our moods, via a class of G proteins known as inhibitory G proteins (G i ).
Read Probe-based bacterial single-cell RNA sequencing predicts toxin regulation. Current Biology. ACS Synthetic Biology. A programmable and red light-regulated CRISPR-dCas9 system for the activation of endogenous genes in Saccharomyces cerevisiae. ACS Synthetic Biology. Nature CellBiology.
Cell metabolism and disease Metabolic perturbations and metabolic reprogramming are associated with common human diseases. In fact, metabolism should not be considered as a self-regulating entity that is independent of other biological pathways. On the contrary, cell metabolism affects or is affected by a multitude of processes.
An open-source FACS automation system for high-throughput cellbiology. Cell Systems. Read Small-molecule aptamer for regulating RNA functions in mammalian cells and animals. Read A general, deep learning tool to segment “ambiguous” biological images and datasets. Might be useful! Wiener D.M.
Read Stem cells were induced to form insulin-secreting pancreas cells and then transplanted into diabetic mice, where they successfully restored glucose levels. Nature CellBiology. A new paper engineers a communication network between cells using DNA instead. .” Synthetic Biology. That’s a win.
Read Stem cells were induced to form insulin-secreting pancreas cells and then transplanted into diabetic mice, where they successfully restored glucose levels. Nature CellBiology. A new paper engineers a communication network between cells using DNA instead. .” Synthetic Biology. That’s a win.
As such, it has been proposed that inhibiting CDK7 would provide a potent means of inhibiting cell cycle progression, which may be especially relevant given that there is compelling evidence from gene knockout studies in mice for lack of an absolute requirement for CDK2, CDK4 and CDK6 for the cell cycle at least in most cell types (M alumbres et al.,
They achieved this by treating mouse fetal ovaries with an enzyme mixture to break them apart into single cells, isolating the ovarian supporting cells, and mixing them with human PGC-like cells to form aggregates, which were then cultured in liquid media for up to 120 days. He also writes the blog De Novo.
Read Deep learning of genomic contexts predicts protein co-regulation and function. Cell Reports. Read RIP-PEN-seq identifies a class of kink-turn RNAs as splicing regulators. Nature CellBiology. Rea Chromatin context-dependent regulation and epigenetic manipulation of prime editing. BMC Bioinformatics.
Post-translational modification of proteins, which includes the alteration of certain amino acid side chains by the introduction of different chemical groups, takes place in eukaryotic and prokaryotic cells. For example, it may result in changes to cell metabolism or lead to alterations in crucial signaling events. NPJ Parkinsons Dis.
Nature Reviews Molecular CellBiology (2009). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular CellBiology (2014). . & Weiss R.
Nature Reviews Molecular CellBiology (2009). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular CellBiology (2014). . & Weiss R.
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