Blog DNA Small Molecule 
Codon
FEBRUARY 13, 2025
By training PLACER on structures stored in the Protein Data Bank, the team taught the model to predict atom arrangements that follow the physical and chemical rules governing protein-small molecule interactions. They synthesized DNA encoding each protein variant, expressed the proteins in E.
Dark Matter Blog
APRIL 4, 2023
The bulk of my nearly three decades of experience up to that point was with drugging protein targets using a variety of modalities, but principally small molecules. And unproductive interactions between the RNA target and the DNA barcodes complicated DEL screening. Screening to Set a Course Screening brings its own challenges.
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NIH Director's Blog: Drug Discovery
MARCH 8, 2016
Instead of the black, printed stripes of the Universal Product Codes (UPCs) that we see on everything from package deliveries to clothing tags, they used short, unique snippets of DNA to label cells. DNA barcoding has already empowered single-cell analysis, including for nerve cells in the brain. PRISM consists of two key components.
Dark Matter Blog
AUGUST 31, 2020
The majority of small molecule drugs induce their therapeutic effects by seeking out and binding to their intended target while avoiding most other molecules in the dense milieu of the cell interior. Our overall mission at Arrakis is to expand the set of “druggable” targets for small-molecule medicines to include RNA.
Dark Matter Blog
JULY 16, 2021
As soon as I learned about DNA and RNA, I wanted to be a molecular biologist. Last stops at RNA My last roles in biotech were where my original passion began: DNA and RNA. My last stop at Arrakis Therapeutics is with a company targeting RNA with small molecules. I wanted to use molecular biology to create drugs.
The Premier Consulting Blog
JULY 9, 2023
During the development of new small molecule drug products, developers must conduct impurity and degradant evaluation at several points in the program and to varying degrees. In addition, this guidance focuses on DNA reactive substances that could potentially cause cancer. Global regulatory agencies, including the U.S.
LifeSciVC
DECEMBER 6, 2022
The following blog post provides some valuable real-world perspective on why this initiative is such an important breakthrough in immunology therapeutics. These hair clip-like molecules clamp onto DNA, thereby turning many genes on and off.
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