PerkinElmer

JANUARY 7, 2020

Successful researchers and companies master and use different technologies, making sure the interpretation of data does not suffer experimental or analytical bias and leads to better success rates and higher profitability for drug developers. The post Assays for the Future of Drug Discovery first appeared on PerkinElmer Blog.

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The Premier Consulting Blog

APRIL 18, 2024

This blog will outline three characteristics of a successful nonclinical program to support entry into clinical trials for a cell or gene therapy product. As in all nonclinical drug development programs, the goal is to identify potential safety issues in humans. Can you identify a safe AND efficacious clinical dose?

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Nvidia Developer: Drug Discovery

APRIL 20, 2020

Molecular dynamics simulations offer accurate approximations of real molecular behavior, which is useful in different stages of drug development. They are used to simulate proteins and lipids and they shed light on how drugs might bind to a protein.

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The Premier Consulting Blog

MAY 31, 2023

As a cornerstone of the drug development process, nonclinical investigational new drug (IND)-enabling studies are essential for supporting first-in-human (FIH) dosing for novel therapeutics. Pharmacology A typical IND-enabling package includes information on the primary, secondary, and safety pharmacology of the drug.

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NIH Director's Blog: Drug Development

OCTOBER 11, 2022

For clinical researchers, click chemistry has emerged as a workhorse in drug discovery and the improved targeting of cancer chemotherapies and other small-molecule drugs. 2004, 126 (46), 15046–15047 [5] In vivo imaging of membrane associated glycans in developing zebrafish. Science 2008, 320 (5876), 664–667. [6]

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Metabolite Tales Blog

OCTOBER 5, 2023

Missing metabolites Accounting for metabolites is a key activity in drug development programs. Trapping agents are described for reactive metabolites that could ordinarily be overlooked due to quenching with endogenous small molecules and protein nucleophiles.

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NIH Director's Blog: Drug Discovery

JANUARY 14, 2016

The technique, which involves flash-freezing molecules in liquid nitrogen and bombarding them with electrons to capture their images with a special camera, has advanced dramatically since its inception thanks to the efforts of many creative minds. The implications for drug discovery and development are perhaps most exciting.

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Alta Sciences

NOVEMBER 5, 2024

Since poorly soluble drugs are difficult to formulate as tablets, formulation scientists are looking to two-piece, liquid-filled hard-shell capsules as a solution. Last but not least, they offer patient benefits with increased bioavailability and sustained release drug delivery. Contact Us today to see how we can help.

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PerkinElmer

FEBRUARY 18, 2021

Which high throughput screening (HTS) approach is the most productive in finding hits for drug development: target-based or phenotypic? Small molecules are making a comeback. PerkinElmer can bring novel reagents, high content screening and analysis, and seamless data integration into pre-clinical drug development. “If

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Biochemical Assays Drugs Small Molecule Pharma Companies 52

PerkinElmer

JANUARY 4, 2021

Mice with 4T1-luc breast cancer xenografts were treated with a small molecule inhibitor of GLUT1 that blocks glucose transport in cancer models. Monitoring the development and progression of diseases linked to aberrant glucose uptake. Screening GLUT inhibitors in drug development. Reference Maric, T., Mikhaylov, G.,

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The Premier Consulting Blog

AUGUST 8, 2024

Typically, new drug development under the 505(b)(2) pathway requires less capital and time and has a higher success rate versus the 505(b)(1) pathway, where the Sponsor develops safety and effectiveness information from scratch. It can simply start with a strategic assessment of your drug product. [i] 89 FR 61474.

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The Premier Consulting Blog

JULY 9, 2023

During the development of new small molecule drug products, developers must conduct impurity and degradant evaluation at several points in the program and to varying degrees. Global regulatory agencies, including the U.S.

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The Premier Consulting Blog

SEPTEMBER 11, 2024

The 505(b)(2) new drug application (NDA) pathway offers a unique opportunity for small molecule developers to bring innovative products to market more efficiently by leveraging existing data they do not own or have right of reference to.

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NIH Director's Blog: Drug Development

JULY 20, 2017

Beginning about 20 years ago, building on increasingly deep understanding of CFTR function derived by NIH-funded academic researchers, a partnership of the Cystic Fibrosis Foundation and a small company called Aurora (that later became Vertex) began searching for small molecules that would allow the abnormal CFTR protein to fold correctly (these are (..)

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NIH Director's Blog: Drug Development

APRIL 7, 2015

After a whirlwind tour of the cutting-edge robotics facility for high throughput screening of small molecules, she joined me and NCATS Director Dr. Chris Austin in announcing that, thanks to an innovative public-private partnership, an experimental drug originally developed to fight cancer is now showing promise against Alzheimer’s disease.

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NIH Director's Blog: Drug Discovery

APRIL 11, 2017

Researchers soon began screening a chemical library and its more than 380,000 traditional drug candidates to find the right small-molecule inhibitor, the preferred compound in drug discovery. Missing was the usual pocket-shaped active site, where a traditional small molecule can readily bind and block function.

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The Premier Consulting Blog

APRIL 25, 2023

Opinions regarding how the new act will impact the industry vary, with predictions ranging from everything remaining at the status quo to the end of animal testing for new drug development and approvals. In the US, new small molecule drugs are developed under the requirements of Sections 505(b)(1) and 505(b)(2) of the FFDCA.

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New Drug Approvals

DECEMBER 3, 2022

852808-04-9 ABT-737 is a small molecule drug that inhibits Bcl-2 and Bcl-xL , two members of the Bcl-2 family of evolutionarily-conserved proteins that share B cl-2 H omology (BH) domains. “Bcl-2 inhibitors: small molecules with a big impact on cancer therapy.” ABT-737 Molecular Weight 813.43

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PerkinElmer

JANUARY 21, 2021

Using drugs that are already on the market was the quickest path forward to evaluate these compounds and possibly help patients now because novel drug development typically takes years. Scientists needed to evaluate the field of potential drugs-and fast. COVID-19 is a difficult disease to understand and treat.

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Dark Matter Blog

APRIL 8, 2020

And we’re flexing our “resilience” muscles – great exercise for anyone in the long game of drug development. Our ambition was to unlock vast swaths of valuable biology inaccessible to medicine today because the proteins involved elude our reach. We’re staying connected and we’re getting to know each other’s kids and pets on video.

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Conversations in Drug Development Trends

MAY 30, 2024

This trend is on the rise despite recent disappointments with clinical trial outcomes, which have the potential to destabilize the industry in the short term regarding drug development strategy and optimal study designs. The shared placebo design is another approach to accelerating drug development in ALS research.

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NIH Director's Blog: Drug Development

MAY 21, 2020

One advantage of this class of therapeutics is that the timelines for their development, testing, and approval are typically shorter than those for drugs made of chemical compounds, called small molecules.

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