LifeSciVC

JULY 1, 2024

Build your social immunity. The adaptive immune response identifies and responds to highly specific antigens associated with infections and cancer. This response often involves the development of immunity thru the generation and maturation of antibodies which help eliminate threats.

Science 86

Science Immune Response Molecular Biology RNA 86

PerkinElmer

NOVEMBER 9, 2022

These cells overexpress PD-L1, leading to inhibition of cytotoxic T-cells by binding to the PD-1 receptor on activated T-cells, and subsequent evasion of an immune response. To date, the only FDA approved immune checkpoint inhibitors targeting the PD-1/PD-L1 pathway are monoclonal antibodies (mAbs).

Small Molecule 52

Small Molecule Research Immune Response FDA Approval 52

PerkinElmer

MAY 6, 2022

One approach currently being explored involves stimulating innate immune response pathways. For example, the STimulator of InterferoN Genes (STING) pathway, which is known to play a critical role in innate immunity in response to viral and bacterial DNA, has also been shown to promote anti-tumor immune responses.

Immune Response 52

Immune Response DNA Clinical Trials Engineering 52

The Premier Consulting Blog

APRIL 18, 2024

This blog will outline three characteristics of a successful nonclinical program to support entry into clinical trials for a cell or gene therapy product. The Cell and Gene Therapy (CGT) field has unprecedented potential to effectively treat and/or cure genetic-based rare and orphan diseases and expand the reach of personalized medicine.

Therapies 52

Therapies Clinical Trials Small Molecule Immune Response 52

Alta Sciences

JANUARY 11, 2024

The in vivo nonclinical study of cell and gene therapies includes a thorough understanding of on-and-off-target activity, immune responses, and other adverse events just to name a few. Image Blog-Thumbnail_The-Altascientist-issue-36.jpg All of which require careful monitoring, and rigorous assessments.

Therapies 52

Therapies Immune Response Disease Virus 52

PerkinElmer

AUGUST 25, 2019

1 AlphaLISA ® Assay Technology Studies done using human tumor cell lines by PerkinElmer Application Scientist Jeanine Hinterneder have contributed to our understanding of how tumor cells develop the ability to evade the immune response. The post Tracking Elusive Breast Cancer Cells first appeared on PerkinElmer Blog.

Protein Expression 52

Protein Expression Immune Response Treatment Research 52

Codon

SEPTEMBER 29, 2024

The new viruses could shuffle surface antigens after encountering an immune response, rapidly adopt new conformations to fit through tight cellular junctions, and self-replicate at safe background levels for years on end. Prior therapeutic viruses had had their replication capabilities crippled out of fear of severe immune responses.

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Engineering Virus DNA Therapies 142

PerkinElmer

JANUARY 25, 2023

This should tell us that further development of new and existing diagnostic tools to understand immune response at the cellular level will be worthwhile in 2023 and beyond, not only for long COVID, but for other conditions too. Click the button below to view other blog posts authored by technical experts on laboratory best practices.

Science 52

Science Laboratories Immune Response Disease 52

Advarra

JANUARY 11, 2024

In this blog, we examine how mRNA can impact cancer treatment, the unique challenges associated with working with mRNA, and strategies for researchers proposing mRNA-based cancer trials. Sites also face difficulty in identifying the right participants for highly specific investigational treatments.

Vaccine 52

Vaccine Therapies Clinical Trials Small Molecule 52

NIH Director's Blog: Drug Development

DECEMBER 15, 2020

A collaboration between several NIH components and 25 of the nation’s top biomedical research institutions, SeroNet will increase the national capacity for antibody testing, while also investigating all aspects of the immune response to SARS-CoV-2, the coronavirus that causes COVID-19.

Clinical Trials 52

Clinical Trials Vaccine Trials Immune Response 52

Dark Matter Blog

JULY 16, 2021

Delivering the IFN-β gene into tumors caused cancer cell apoptosis and activated both innate and adaptive anti-tumor immune responses. We saw a new phenomenon with the emergence of social media that enabled us to follow the experiences of patients through their blogs and social media postings.

Small Molecule 52

Small Molecule RNA Clinical Trials DNA 52

NIH Director's Blog: Drug Development

FEBRUARY 1, 2022

What’s especially promising about this approach is it could be used in combination with treatments that work in other ways, such as by preventing virus that’s already infected cells from growing or limiting an excessive and damaging immune response to the infection.

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Virus Clinical Trials Engineering Treatment 52

New Drug Approvals

DECEMBER 16, 2023

3 Additionally, iptacopan has the benefit of targeting factor B, which only affect the alternative complement pathway, leaving the classic and lectin pathway untouched for the body to still mount adequate immune responses against pathogens. of patients experienced a sustained hemoglobin improvement without transfusions respectively.

FDA 62

FDA Small Molecule FDA Approval Treatment 62

NIH Director's Blog: Drug Development

OCTOBER 27, 2020

While further study is needed to understand all the details and their implications, it suggests that this interaction may alter important aspects of the human immune response, including blocking interferon signals that are crucial for sounding the alarm to prevent serious illness.

Drug Development 52

Drug Development Drugs Virus Science 52

NIH Director's Blog: Drug Development

MARCH 18, 2021

These days, the Veesler lab has been hard at work to understand SARS-CoV-2 and the human immune response to the virus. The researcher didn’t see SARS-CoV-2 coming, but he recognized the potential for some kind of novel coronavirus outbreak in the future.

Virus 52

Virus Immune Response Clinical Trials Treatment 52

NIH Director's Blog: Drug Development

MAY 21, 2020

References : [1] Humoral immune response and prolonged PCR positivity in a cohort of 1343 SARS-CoV 2 patients in the New York City region. In the U.S. Stay tuned for more information about these potentially significant advances in the next few months. medRxiv.

Virus 52

Virus Vaccine Laboratories Science 52

NIH Director's Blog: Drug Development

FEBRUARY 16, 2021

They are called immune modulators because they help to minimize the effects of an overactive immune response in some COVID-19 patients. This response, called a “cytokine storm,” can lead to acute respiratory distress syndrome, multiple organ failure, and other life-threatening complications.

Clinical Trials 52

Clinical Trials Trials Hospitals Vaccine 52

Codon

APRIL 30, 2023

In one experiment, the microneedle patches were used to deliver a SARS-CoV-2 vaccine into mice, producing immune responses similar to a traditional injection. Printed vaccines caused mice to have a faster immune response. But the printed vaccines are very good! That’s a win.

Vaccine 52

Vaccine DNA Engineering RNA 52

Codon

APRIL 30, 2023

In one experiment, the microneedle patches were used to deliver a SARS-CoV-2 vaccine into mice, producing immune responses similar to a traditional injection. Printed vaccines caused mice to have a faster immune response. But the printed vaccines are very good! That’s a win.

Vaccine 52

Vaccine DNA Engineering RNA 52

Codon

JULY 27, 2023

a lower risk of immune responses. reports Cas9 proteins that can penetrate into the central nervous system without being packaged into an adeno-associated virus, all while causing a lower immune response than a prior version of the same technology. ” A blog by Olek Pisera, PhD student at UC Irvine.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

a lower risk of immune responses. reports Cas9 proteins that can penetrate into the central nervous system without being packaged into an adeno-associated virus, all while causing a lower immune response than a prior version of the same technology. ” A blog by Olek Pisera, PhD student at UC Irvine.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

APRIL 9, 2023

Read An engineered HIV-1 Gag-based VLP displaying high antigen density induces strong antibody-dependent functional immune responses. Read Combinatorial gene therapy for epilepsy: Gene sequence positioning and AAV serotype influence expression and inhibitory effect on seizures. Gene Therapy. Tarrés-Freixas F. npj Vaccines.

Therapies 52

Therapies RNA Engineering Vaccine 52

Codon

APRIL 23, 2023

Unfortunately, they can also trigger immune responses, and they are not super efficient at gene-editing some parts of the brain. These ribonucleoproteins also caused a lower immune response compared to the viruses, and are much easier to make in the lab. billion together. Press release.

Vaccine 52

Vaccine DNA Virus Engineering 52

Codon

APRIL 23, 2023

Unfortunately, they can also trigger immune responses, and they are not super efficient at gene-editing some parts of the brain. These ribonucleoproteins also caused a lower immune response compared to the viruses, and are much easier to make in the lab. billion together. Press release.

Vaccine 52

Vaccine DNA Virus Engineering 52

Codon

APRIL 16, 2023

Skin microbes can trigger strong immune responses. These microbes were engineered to express tumor antigens that could “elicit T cells that were licensed by the commensal immune program but specific for a tumor,” including both CD4+ and CD8+ T cells, according to the study.

Engineering 52

Engineering DNA RNA Science 52

PLOS: DNA Science

FEBRUARY 20, 2025

All 38 editions of the life science textbooks I’ve written have chapters on immunology that clearly define vaccine: “an inactive, disabled, or part of a pathogen that stimulates an immune response. Vaccines range in size from entire pathogens to their macromolecules, such as proteins or nucleic acids.”

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Vaccine Science RNA Disease 94