Codon

JULY 27, 2023

a lower risk of immune responses. reports Cas9 proteins that can penetrate into the central nervous system without being packaged into an adeno-associated virus, all while causing a lower immune response than a prior version of the same technology. ” A blog by Olek Pisera, PhD student at UC Irvine.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

APRIL 30, 2023

In one experiment, the microneedle patches were used to deliver a SARS-CoV-2 vaccine into mice, producing immune responses similar to a traditional injection. Printed vaccines caused mice to have a faster immune response. It’s an easier way to get CRISPR into cells! But the printed vaccines are very good!

Vaccine 52

Vaccine DNA Engineering RNA 52

Codon

APRIL 30, 2023

In one experiment, the microneedle patches were used to deliver a SARS-CoV-2 vaccine into mice, producing immune responses similar to a traditional injection. Printed vaccines caused mice to have a faster immune response. It’s an easier way to get CRISPR into cells! But the printed vaccines are very good!

Vaccine 52

Vaccine DNA Engineering RNA 52

Codon

SEPTEMBER 29, 2024

On the surface, they hadn't deviated much from the early 2020s: a virus infected a cell and released the genetic therapy hidden within. Dozens of diverse chemical markers and de novo , evolutionary distinct proteins littered the virus' surface, indicating a previously unseen biological logic.

Engineering 142

Engineering Virus DNA Therapies 142

NIH Director's Blog: Drug Development

JUNE 30, 2020

A major one is: just how well do those particular antibodies neutralize the virus to fight off the infection and help someone recover from COVID-19? Fortunately, most people get better—but should the typical antibody response take the credit? Not surprisingly, all volunteers had produced antibodies in response to the virus.

Immune Response 52

Immune Response Virus Vaccine Research 52

Codon

APRIL 9, 2023

Read Rational design of a highly immunogenic prefusion-stabilized F glycoprotein antigen for a respiratory syncytial virus vaccine. Read An engineered HIV-1 Gag-based VLP displaying high antigen density induces strong antibody-dependent functional immune responses. The New England Journal of Medicine. McGrady N.R. Gene Therapy.

Therapies 52

Therapies RNA Engineering Vaccine 52

NIH Director's Blog: Drug Development

MAY 21, 2020

B38 blocks SARS-CoV-2 from binding to the ACE2 receptor (light pink) of a human cell, ACE2 is what the virus uses to infect cells. References : [1] Humoral immune response and prolonged PCR positivity in a cohort of 1343 SARS-CoV 2 patients in the New York City region. In the U.S. Preprint Posted May 5, 2020. [2]

Virus 52

Virus Vaccine Laboratories Science 52

NIH Director's Blog: Drug Development

FEBRUARY 16, 2021

They are called immune modulators because they help to minimize the effects of an overactive immune response in some COVID-19 patients. This response, called a “cytokine storm,” can lead to acute respiratory distress syndrome, multiple organ failure, and other life-threatening complications.

Clinical Trials 52

Clinical Trials Trials Hospitals Vaccine 52

NIH Director's Blog: Drug Development

MARCH 18, 2021

Yet they are the source for many of the viruses that have spilled over into humans with devastating effect, including rabies, Ebola virus, Nipah and Hendra viruses, severe acute respiratory syndrome coronavirus (SARS-CoV), and, likely, SARS-CoV-2. Despite carrying all of these viruses, bats rarely show symptoms of being sick.

Virus 52

Virus Immune Response Clinical Trials Treatment 52

NIH Director's Blog: Drug Development

FEBRUARY 1, 2022

The ACE2 drug candidate, which is soluble and degrades in the body, also proved ineffective in neutralizing the virus. In the lab, it also appeared to neutralize the virus as well as monoclonal antibodies used to treat COVID-19. In fact, the decoy bound just as well, if not better, to new variants compared to the original virus.

Virus 52

Virus Clinical Trials Engineering Treatment 52

Codon

APRIL 16, 2023

Skin microbes can trigger strong immune responses. These microbes were engineered to express tumor antigens that could “elicit T cells that were licensed by the commensal immune program but specific for a tumor,” including both CD4+ and CD8+ T cells, according to the study. Nature Communications. Science Advances.

Engineering 52

Engineering DNA RNA Science 52

PLOS: DNA Science

FEBRUARY 20, 2025

Influenza incidence and severity are increasing , against a backdrop of novel drifts (small genetic changes) and shifts (larger changes) to the virus, all against a backdrop of novel infection pathways, such as birds to cows to people. The mRNA in COVID vaccines tells cells to produce the virus’s spike protein. Vaccines work!!!

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Vaccine Science RNA Disease 94