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Codon Digest: Injected Gene Editors

Codon

Read A new DNA polymerase variant, called RT-KTq I614Y, can directly detect RNA modifications, including pseudouridine (Ψ) and queuosine (Q). By combining this new variant with standard sequencing methods, it’s possible to identify RNA modifications in a really simple way. Nucleic Acids Research. Communications Biology.

DNA 52
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Codon Digest: Seeing Colors After Gene Therapy

Codon

A LEGO robot , made by undergraduate students at Arizona State University, pours sucrose gradients (a tube with dense liquid at the bottom, and less dense liquid at the top), which are used to separate, say, proteins from RNA by spinning them really fast in centrifuges. How do transcription factors couple up with the correct RNA molecule?

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Codon Digest: Seeing Colors After Gene Therapy

Codon

A LEGO robot , made by undergraduate students at Arizona State University, pours sucrose gradients (a tube with dense liquid at the bottom, and less dense liquid at the top), which are used to separate, say, proteins from RNA by spinning them really fast in centrifuges. How do transcription factors couple up with the correct RNA molecule?

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Models of Life

Codon

But, regardless of which was first, they all operated with the same core data as their mechanism for understanding life: messenger RNA ( mRNA ). At best, the corporations with the best models released weak versions to the public under non-commercial licenses. There was scFormer in 2022, scGPT in 2023, and plenty of others.

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BioDAOs are Community-Owned Research Translation Engines, Not Investment DAOs

Molecule Blog

The university then licenses the IP to an existing pharmaceutical company or a biotech startup, which takes on Investigational New Drug (IND) enabling studies. This work is often grant-funded and carried out in academic labs until patents or other intellectual property (IP) are filed by the university’s technology transfer office (TTO).

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Gene-Edited Bananas

Codon

In 2016, her team demonstrated that, by adding short snippets of DNA or RNA — which can target and “shut down” the MaMADS regulatory proteins — to bananas, it is possible to slow their ripening. Most of this genetic material codes for proteins: DNA is transcribed into RNA, which is then translated into proteins.

DNA 52
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Gene-Edited Bananas

Codon

In 2016, her team demonstrated that, by adding short snippets of DNA or RNA — which can target and “shut down” the MaMADS regulatory proteins — to bananas, it is possible to slow their ripening. Most of this genetic material codes for proteins: DNA is transcribed into RNA, which is then translated into proteins.

DNA 52