Dark Matter Blog

AUGUST 27, 2020

A few years ago, at Arrakis Therapeutics, we set out to conquer a strange new territory, drugging RNA structures with small molecules. Dramatic discoveries of small molecules targeting SMN2 Prior to those outstanding therapeutic achievements, in 2015, a group from Novartis published an important paper in Nature Chemical Biology.

Small Molecule 52

Small Molecule RNA Clinical Trials Drugs 52

Codon

FEBRUARY 13, 2025

By training PLACER on structures stored in the Protein Data Bank, the team taught the model to predict atom arrangements that follow the physical and chemical rules governing protein-small molecule interactions. He also writes on a blog focused on the intersection of biology and AI at owlposting.com.

Small Molecule 124

Small Molecule Engineering Production DNA 124

addgene Blog

JULY 25, 2024

originally developed the ELISA assay to measure antibody levels, scientists have since adapted it for a host of different proteins and small molecules from a variety of sample types (Engvall 1971). An enzyme-linked immunosorbent assay (ELISA) is a versatile method used to quantify the level of target antigen in a sample.

Small Molecule 94

Small Molecule Research Drugs 94

Atomwise Blog

MARCH 9, 2022

At the American Chemical Society Spring National Meeting & Expo, Atomwise members were selected to present their research and work. Learn what our Atoms have been working on below and visit Atomwise at ACS Spring 2022 National Meeting for other presentation sessions.

Small Molecule 52

Small Molecule Research 52

FDA Law Blog: Biosimilars

AUGUST 27, 2024

The series, held virtually on Tuesday and Thursday afternoons on ACI’s interactive platform, will provide an in-depth review of Hatch-Waxman and the BPCIA, as well as other intellectual property basics related to small molecules and biologics. FDA Law Blog readers receive a 10% discount (use FDA Law Blog promo code: D10-999-FDA25).

Small Molecule 59

Small Molecule FDA Regulations Science 59

The Premier Consulting Blog

NOVEMBER 20, 2024

In the case of urgent or immediate public interest, process validation may be conducted concurrently with manufacturing the commercial small molecule or biologic product to expedite product availability for patients.

Small Molecule 52

Small Molecule Drugs FDA Production 52

NIH Director's Blog: Drug Development

OCTOBER 30, 2018

Now comes word of another absolutely incredible use of cryo-EM: determining with great ease and exquisite precision the structure of the smaller organic chemical compounds, or “small molecules,” that play such key roles in biological exploration and drug development. Also analyzed were eight less-familiar small molecules.

Small Molecule 52

Small Molecule Science Drug Development Organic Chemistry 52

Dark Matter Blog

JANUARY 16, 2023

We want to mark this progress with some updates and perspectives in the Dark Matter blog. Our terra firma is small-molecule medicines. As we know, small molecules have been the mainstay of our pharmacopeia for several centuries and have, almost without exception, targeted proteins.

Small Molecule 52

Small Molecule RNA Drugs Disease 52

FDA Law Blog: Biosimilars

SEPTEMBER 11, 2024

Last week’s guidance is featured on FDA’s new nitrosamines webpage and recommends that manufacturers implement revisions to control measures by August 1, 2025, noting that manufacturers and sponsors of approved products were expected to complete evaluations for small molecule nitrosamines last year.

Small Molecule 105

Small Molecule FDA Production Drugs 105

FDA Law Blog: Biosimilars

JULY 24, 2024

FDA Law Blog readers receive a 10% discount off the tuition fee (promo code D10-999-FDA25 ). Karst will moderate a panel discussion, titled “Fireside Chat on the Future of the FDA: Regulatory Initiatives, and Agency Developments for Hatch Waxman Practitioners to Watch.” You can register for the conference here.

Small Molecule 52

Small Molecule Clinical Trials FDA Pharmaceuticals 52

FDA Law Blog: Biosimilars

JULY 21, 2023

This series will provide an in-depth review of Hatch-Waxman and the BPCIA along with other IP basics relative to small molecules and biologics. Save 10% with the FDA Law Blog promo code: D10-999-FDA24. To learn more visit here , or email at customerservice@americanconference.com.

Small Molecule 52

Small Molecule Regulations FDA Science 52

LifeSciVC

APRIL 24, 2024

and whether a molecule’s pharmacology can help to mitigate safety risk. Especially for oligo or small molecule discovery and development, it’s important to understand whether there are highly homologous sequences or proteins that may be impacted by a given therapeutic approach. based on “tool” molecule precedent.

Production 117

Production Small Molecule Regulations Trials 117

PerkinElmer

NOVEMBER 9, 2022

Recent efforts have focused on the development of small-molecule inhibitors as an alternative approach to therapeutically target PD-1 or PD-L1. Compared with mAbs, small molecules can provide increased oral bioavailability, bio-efficiency, and shorter half-life activity.

Small Molecule 52

Small Molecule Research Immune Response FDA Approval 52

Molecular Design

DECEMBER 31, 2024

My pulse will be quickenin' With each drop of strychnine We feed to a pigeon It just takes a smidgin To poison a pigeon in the park Tom Lehrer, Poisoning Pigeons in the Park | video ** Ill be reviewing the H2024 study (Occurrence of Natural Selection in Successful Small Molecule Drug Discovery) in this post.

Small Molecule 85

Small Molecule Drugs Production Science 85

PerkinElmer

JANUARY 21, 2021

AlphaLISA assay technology can be used in small molecule discovery but can also be applied to large molecule discovery, including biologics, vaccines and cell-based therapies. The next focus for the team is to identify similar small molecules to the 25 hits they uncovered and then try to improve the potency of each.

Treatment 52

Treatment Small Molecule Drugs Virus 52

PerkinElmer

SEPTEMBER 8, 2019

The addition of Cisbio’s capabilities to PerkinElmer will enable life science researchers to have access to assay tools that address the broad diversity of target types and biological configurations, for both small molecule and biologic drug discovery. Learn more about Cisbio here.

Cell Based Assays 52

Cell Based Assays Small Molecule Science Pharmaceuticals 52

BMG Labtech

APRIL 16, 2024

In this blog, we take stock of progress, look at what’s in store for drug development, and give examples of ways microplate readers can help advance research into molecular glues. Conventional drug development has often focused on finding small molecules that fit the active site of a protein.

Targeted Protein Degradation 40

Targeted Protein Degradation Small Molecule Drug Development Disease 40

Conversations in Drug Development Trends

MAY 30, 2024

Other researchers are investigating approaches that use AAV-mediated trophic support and antibody-based therapies, such as vaccines and small molecule drugs, to modify various protein expressions. For a more in-depth discussion on challenges and solutions to ALS research, read our blog.

Treatment 81

Treatment Clinical Trials Small Molecule Therapies 81

Dark Matter Blog

JUNE 21, 2023

Since our company’s founding in 2015, we have taken the long view and been singularly focused on building an extremely flexible and broadly applicable platform that can develop a host of RNA‑targeted small molecules (rSMs) to deliver precision medicines for dozens of targets that have been out of reach for conventional approaches.

Small Molecule 52

Small Molecule RNA Pharma Companies Science 52

The Strateos Blog: Drug Discovery

MARCH 18, 2022

Strateos had the pleasure of participating at the PharmaIQ Live: Smartlab Digital 2022 conference held between March 8-9th, which focused on the potential of Lab 4.0 strategies to increase the speed, efficiency and reduce the cost of the drug discovery process. John Harman, Sr.

Small Molecule 52

Small Molecule Laboratories Production Drugs 52

PerkinElmer

JANUARY 7, 2020

Here are two predictions for the future: Alpha CETSA ® for target engagement While traditional assay methods detect either the displacement of a radioligand binding to the target by a competitor molecule, or the modulation of some function of the target, a new method is making headway: Cellular Thermo Shift Assay (CETSA) from Pelago Bioscience.

Small Molecule 52

Small Molecule Cell Based Assays Drugs Drug Development 52

BMG Labtech

NOVEMBER 21, 2023

Effectors of signal transmission events Second messengers are small molecules or ions that transmit signals received at the cell surface to the inside environment of the cell (Fig.

Small Molecule 40

Small Molecule Regulations Research Cell Biology 40

Dark Matter Blog

AUGUST 31, 2020

The majority of small molecule drugs induce their therapeutic effects by seeking out and binding to their intended target while avoiding most other molecules in the dense milieu of the cell interior. Our overall mission at Arrakis is to expand the set of “druggable” targets for small-molecule medicines to include RNA.

RNA 52

RNA Small Molecule Bioinformatics Computational Chemistry 52

Dark Matter Blog

JULY 16, 2021

My last stop at Arrakis Therapeutics is with a company targeting RNA with small molecules. I was enticed by Arrakis’ founder Jen Petter to serve in one more operational role, leading the research group at Arrakis as the company launched as one of the first biotechs to target RNA with drug-like small molecules.

Small Molecule 52

Small Molecule RNA Clinical Trials DNA 52

Atomwise Blog

JULY 11, 2022

These methods typically use a physics-based scoring function to generate ranked lists of plausible poses, which are models of physical interactions between small molecules and protein targets. They are often effective at suggesting good poses, but the best ones are typically not at the top of the list.

Small Molecule 52

Small Molecule Drugs 52

Metabolite Tales Blog

FEBRUARY 15, 2024

As part of a team, the successful applicant will undertake a variety of interesting projects to deliver purified small molecules to collaborators and for our own proprietary projects in the field of biotransformation and natural products drug discovery. The role is predominantly lab-based.

Small Molecule 52

Small Molecule Laboratories Production Pharmaceuticals 52

NIH Director's Blog: Drug Discovery

APRIL 11, 2017

Researchers soon began screening a chemical library and its more than 380,000 traditional drug candidates to find the right small-molecule inhibitor, the preferred compound in drug discovery. Missing was the usual pocket-shaped active site, where a traditional small molecule can readily bind and block function.

Small Molecule 52

Small Molecule Science Drug Development Disease 52

Metabolite Tales Blog

DECEMBER 13, 2023

N -glucuronidation: the human element By Julia Shanu-Wilson In our last blog of the year, we look at why N -glucuronidation of drugs is important in human drug metabolism. Conjugation of small molecule drugs to glucuronic acid is catalysed by several UGTs to frequently form N – and O -glucuronides. Derun Li, David L.

Small Molecule 59

Small Molecule Metabolic Stability Treatment Drugs 59

The Premier Consulting Blog

APRIL 18, 2024

This blog will outline three characteristics of a successful nonclinical program to support entry into clinical trials for a cell or gene therapy product. Thus, while the same types of safety endpoints need to be evaluated, the studies done to do so often look different compared to those for a small molecule.

Therapies 52

Therapies Clinical Trials Small Molecule Immune Response 52

Practical Cheminformatics

JANUARY 8, 2024

Gotta be SAFE: A New Framework for Molecular Design [link] A blog post by Edward Williams from Terray Therapeutics introduced Contrastive Optimization for Accelerated Therapeutic Inference (COATI). This novel embedding considers both the topological and three-dimensional structure of molecules. In this paper, the authors then used 1.1

Drugs 139

Drugs Small Molecule Bioinformatics Packaging 139

PerkinElmer

MAY 28, 2020

The EnSight multimode plate reader offers best-in-class luminescence detection technology at high throughput rates (less than 1 min per 96-well plate) and can support biologics, vaccines, and small molecule research.

Vaccine 52

Vaccine Disease Virus Small Molecule 52

Dark Matter Blog

JULY 19, 2021

Or should I say back to retirement, as he was comfortably relaxing at home back in 2016 when Jen Petter lured him back into the fray with the siren call of developing a new class of RNA-targeted small-molecule medicines here at Arrakis. I won’t dwell on Jim’s many accomplishments here.

Small Molecule 52

Small Molecule RNA Science Therapies 52

The Premier Consulting Blog

MAY 31, 2023

In this blog post, we outline typical elements of an IND-enabling package for a single ascending dose (SAD)/multiple ascending dose (MAD) study of an oral small molecule for a non-cancer indication with a maximum of 14 days of dosing.

Packaging 52

Packaging Pharmacokinetics Small Molecule Clinical Trials 52

The Premier Consulting Blog

APRIL 18, 2024

In this blog, we will address common questions we receive from our clients and aspects to consider when designing those nonclinical studies. If the compound is not active in any species (eg, human-specific gene target), a surrogate molecule could be used. In which species should the toxicity study be conducted?

Therapies 52

Therapies Small Molecule Production Clinical Trials 52

The Premier Consulting Blog

JANUARY 31, 2023

This blog post will explain how the WoE approach is used in toxicology studies and how the S1B(R1) addendum could affect your nonclinical program. Background The addendum’s development was informed by both prospective and retrospective evaluations of animal carcinogenicity data submitted to the ICH.

Small Molecule 52

Small Molecule Pharmaceuticals FDA Production 52

FDA Law Blog: Biosimilars

MARCH 3, 2024

Scope Part 1— though the Act’s restrictions are seemingly limited to equipment and services that perform activities in relation to “biological materials”—a term that is not defined in the Act—the restrictions may still impact manufacturers of small molecule drugs or API that contract with third-parties using covered products or services as part of, (..)

Small Molecule 102

Small Molecule Government FDA Approval Regulations 102

The Strateos Blog: Drug Discovery

SEPTEMBER 24, 2021

OVERCOMING BOTTLENECKS IN TRADITIONAL WORKFLOWS Conventional small molecule drug discovery workflows take upwards of 6 years to progress from target ID through to IND submission with key medicinal chemistry (MedChem) steps involved in lead generation. Ben Miles, Ph.D.,

Synthetic Chemistry 52

Synthetic Chemistry Small Molecule Production Science 52