Blog Small Molecule Virus 
PerkinElmer
JANUARY 21, 2021
It is particularly prevalent on cells that line the air sacs in lungs, hence the rampaging respiratory effects we’ve come to associate with the virus. AlphaLISA assay technology can be used in small molecule discovery but can also be applied to large molecule discovery, including biologics, vaccines and cell-based therapies.
PerkinElmer
MAY 28, 2020
Unfortunately, the road towards treatment can be time-consuming, especially when utilizing assays with live virus. Additionally, procuring the live virus for an evaluation assay is very difficult and labor intensive. Such high safety measures, although essential, can extend the timing of the development of a vaccine.
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NIH Director's Blog: Drug Discovery
APRIL 11, 2017
Researchers soon began screening a chemical library and its more than 380,000 traditional drug candidates to find the right small-molecule inhibitor, the preferred compound in drug discovery. Missing was the usual pocket-shaped active site, where a traditional small molecule can readily bind and block function.
NIH Director's Blog: Drug Development
MAY 21, 2020
B38 blocks SARS-CoV-2 from binding to the ACE2 receptor (light pink) of a human cell, ACE2 is what the virus uses to infect cells. One advantage of this class of therapeutics is that the timelines for their development, testing, and approval are typically shorter than those for drugs made of chemical compounds, called small molecules.
Advarra
JANUARY 11, 2024
In this blog, we examine how mRNA can impact cancer treatment, the unique challenges associated with working with mRNA, and strategies for researchers proposing mRNA-based cancer trials. Immunomodulatory Proteins Immunomodulators are molecules influencing the pathways regulating the body’s immune system activities.
New Drug Approvals
JANUARY 31, 2024
BLZ945 decreases the growth of malignant cells in the mouse mammary tumor virus-driven polyomavirus middle T antigen (MMTV-PyMT) model of mammary carcinogenesis. BLZ945 attenuates the turnover rate of TAMs while increasing the number of CD8+ T cells that infiltrate cervical and breast carcinomas. ES/MS m/z 398.1(MH 3 : 100091.
NIH Director's Blog: Drug Discovery
MARCH 8, 2016
Golub and colleagues produced the library by using a virus to insert a distinct DNA barcode, just 24 nucleotides long, stably into the genomes of each genetically distinct tumor cell line. With PRISM, it’s now feasible to screen entire small molecule libraries across large panels of cancer cell lines.
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