PerkinElmer

AUGUST 13, 2020

The virus, which can cause a severe form of pneumonia and lead to acute respiratory distress, currently has no FDA-approved targeted therapeutic or vaccine. For this reason, researchers around the globe are scrambling to understand this novel virus and figure out its potentially targetable vulnerabilities.

Virus 52

Virus Cell Based Assays FDA Approval Clinical Trials 52

addgene Blog

OCTOBER 12, 2023

The blood-brain-barrier (BBB) exists to prevent substances in the blood, like proteins and viruses, from crossing into the brain. While helpful from a biological standpoint, it makes delivering AAVs to the brain difficult.

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Virus Research 131

addgene Blog

OCTOBER 3, 2023

Once ~400 cases had amassed in places around the world, hypotheses began to develop that this illness was caused by either SARS-CoV-2, Adenovirus type 41 (AdV-41), or Adenovirus-Associated Virus type 2 (AAV2) – or some unprecedented combination of the three (Servellita et al.,

Virus 126

Virus 126

addgene Blog

OCTOBER 19, 2023

Adeno-associated viruses (AAV) are an important biological tool that allow scientists to express a gene of interest in a cell or animal model. AAV plasmids contain several important elements, but among the most important are the inverted terminal repeats (ITRs). ITRs are the elements that make an AAV plasmid an AAV plasmid.

Virus 121

Virus 121

addgene Blog

JULY 25, 2023

So, if you’ve ever wondered what goes into ‘making virus’ or what gag and pol stand for, we demystify all components of viral vectors here! For safety and production reasons, multiple plasmids with many components are used to package lab grown viruses. It can be intimidating at first to look at so many plasmid maps and protocols!

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Virus Packaging Production 95

BMG Labtech

MARCH 11, 2024

In this blog, we look at immunoassays over the years, provide some examples of current and emerging applications, discuss some tips for optimization, and look at some of the benefits of the different ELISA options available to researchers.

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Vaccine Molecular Biology Laboratories Virus 98

addgene Blog

JULY 30, 2024

As editor of Addgene’s eBooks — including the recently released Viral Vectors 101 2 nd edition — I was incredibly excited when we picked our viral vector service as one of those stories.

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Engineering Virus 93

addgene Blog

JUNE 1, 2023

While it is tempting to just dive right in and start injecting your virus, a successful AAV experiment starts with validation and optimization. Using AAV vectors in complex biological systems can be tricky at best, and downright infuriating at worst.

Virus 97

Virus 97

addgene Blog

AUGUST 15, 2024

What do a viral vector production facility, food allergy testing lab, and the grad student down the hall from you have in common? All of them rely on standard curves in their day-to-day work.

Virus 96

Virus Production 96

PLOS: DNA Science

JUNE 13, 2024

The virus SARS-CoV-2 emerged in Wuhan, home of a premiere research institute that focuses on viruses. An altered virus could have escaped. Evidence that the virus emerged, or escaped, from the wildlife trade is lacking. Her points: 1. Coincidence? I’ve never thought so. RaTG13 shares about 96.1%

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Virus RNA DNA Science 52

NIOSH Science Blog: Drugs

FEBRUARY 3, 2023

Air filtration units were widely used during large wildfire outbreaks in the western United States,[1] and their use surged nationwide during the COVID-19 pandemic as a way to reduce exposure to aerosols containing the SARS-CoV-2 virus.

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Virus Production Engineering Disease 97

Codon

SEPTEMBER 29, 2024

On the surface, they hadn't deviated much from the early 2020s: a virus infected a cell and released the genetic therapy hidden within. Dozens of diverse chemical markers and de novo , evolutionary distinct proteins littered the virus' surface, indicating a previously unseen biological logic.

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Engineering Virus DNA Therapies 141

PerkinElmer

JUNE 14, 2021

In October last year, remdesivir was the first drug approved by the FDA for treating the SARS-CoV-2 virus. Remdesivir was originally developed to treat hepatitis C and was subsequently investigated for Ebola virus disease and Marburg virus infections before being studied as a post-infection treatment for COVID-19.

Virus 52

Virus RNA Vaccine Treatment 52

PerkinElmer

MAY 28, 2020

Unfortunately, the road towards treatment can be time-consuming, especially when utilizing assays with live virus. Additionally, procuring the live virus for an evaluation assay is very difficult and labor intensive. Such high safety measures, although essential, can extend the timing of the development of a vaccine.

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Vaccine Disease Virus Small Molecule 52

PerkinElmer

JULY 13, 2020

From this data, scientists have begun to try to classify different subtypes and create phylogenetic trees of the virus to understand how the viral genome is evolving as it spreads across the globe. The question as to whether these genome variations lead to different strains of the novel virus (i.e. Why and how do viruses evolve?

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Treatment Virus DNA RNA 52

PerkinElmer

JULY 13, 2020

The complex relationship between a virus and its host is one of the hottest topics in science right now, and has been given considerable attention in recent weeks as a result of the race to understand the virus that causes COVID-19 and its potential vulnerabilities.

RNA 52

RNA Virus Laboratories Science 52

NIOSH Science Blog: Drugs

FEBRUARY 8, 2023

Avian influenza A viruses are classified into the following two categories: Highly pathogenic avian influenza (HPAI) virus strains are extremely infectious, often fatal to chickens, and can spread rapidly from flock-to-flock. Avian influenza (bird flu) is caused by infection with avian influenza (flu) Type A viruses.

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Virus Disease 61

EG Life Sciences

FEBRUARY 15, 2023

Going into the third year of the pandemic, we know that the virus still impacts industry operations. Together, top vaccine development companies can join efforts, being transparent with one another to finally stop the spread of the virus around the world.

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Drug Development FDA Approval Drugs Virus 52

New Drug Approvals

DECEMBER 26, 2022

1 heavy chain (1-456) (human vh (homo sapiens ighv1-69*01(ighd)-ighj4*01 (90.1%)) (8.8.19) (1-126) -homo sapiens ighg1*03 Immunoglobulin g1, anti-(human respiratory syncytial virus fusion protein)(human monoclonal med18897.gamma.1-chain), 2] [3] Nirsevimab is designed to bind to the fusion protein on the surface of the RSV virus. [4]

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Virus Clinical Trials Trials Disease 52

FDA Law Blog: Biosimilars

APRIL 7, 2025

However, several of Zenrelias promotional materialsspecifically, FDA looked at a consumer-directed website, a product brochure and risk tracker, and a slide deckomitted the specific phrase from modified live virus vaccines from the boxed warning found in the Important Safety Information.

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PerkinElmer

AUGUST 18, 2020

The time sensitivity of virus research, combined with an increasing complexity of bench tasks, can make it helpful for labs to increase automaticity of experiments. For this reason, it might be necessary for research teams to screen many potential leads before they find one or two with strong potential. Sources Zhang et al.

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Virus Vaccine RNA DNA 52

PerkinElmer

FEBRUARY 28, 2022

Fast-forward to today, and thousands of scientists have turned their attention to studying SARS-CoV-2, the virus responsible for the current COVID-19 pandemic. This research pivot led to a torrent of scientific papers describing the structure and biology of the virus being published. μl of ATPlite-substrate per well. 2021;102(4).

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Virus Vaccine Clinical Trials Treatment 52

NIH Director's Blog: Drug Development

MARCH 18, 2021

Yet they are the source for many of the viruses that have spilled over into humans with devastating effect, including rabies, Ebola virus, Nipah and Hendra viruses, severe acute respiratory syndrome coronavirus (SARS-CoV), and, likely, SARS-CoV-2. Despite carrying all of these viruses, bats rarely show symptoms of being sick.

Virus 52

Virus Immune Response Clinical Trials Treatment 52

Advarra

JUNE 13, 2024

This blog describes why hazard communications are necessary and what an effective SOP should include. Depending on the genetic modifications of the oncolytic virus, exposure may result in an infection or disease with symptoms mimicking those from an infection by the native parent virus. Why Do You Need an SOP About IP Hazards?

Clinical Trials 52

Clinical Trials Engineering Trials Virus 52

NIH Director's Blog: Drug Discovery

NOVEMBER 5, 2020

Because SARS-CoV-2 is so highly infectious, basic researchers without access to specially designed biosafety facilities may be limited in their ability to study the virus. While the quantum dots may bind and enter human cells just like the virus, they can’t cause an infection. But these harmless quantum dots offer a safe workaround.

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Research Laboratories Laboratories Science Drugs 85

addgene Blog

MAY 30, 2023

Adeno-associated virus (AAV) is a single stranded, Parvoviridae DNA virus, packaged in a non-enveloped icosahedral capsid, that can be used to express genes of interest in cell and animal models. This post was contributed by guest blogger Didem Goz Ayturk with edits and updates from Addgenies Karen Guerin and Susanna Stroik.

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Virus Packaging DNA Laboratories 58

PerkinElmer

MAY 7, 2021

The post Hey…Walkaway on the Automated Side first appeared on PerkinElmer Blog. Countless hours and valuable resources are often spent on physically preparing and loading plates into readers-that time could be spent analyzing data or researching a novel, potentially breakthrough target.

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Vaccine DNA Compliance Virus 52

Advarra

AUGUST 8, 2023

In this blog, we summarize the growth, risks, and regulatory requirements for gene therapy research. Viral infection involves the transfer of the virus’ genetic material to host cells, making viruses ideal tools for gene transfer—once the genes responsible for viral replication and disease are removed.

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Therapies Research Engineering Clinical Research 52

NIH Director's Blog: Drug Development

JUNE 30, 2020

A major one is: just how well do those particular antibodies neutralize the virus to fight off the infection and help someone recover from COVID-19? In the Nussenzweig lab, the team has spent years searching for broadly neutralizing antibodies against the human immunodeficiency virus (HIV ). Yet many critical questions remain.

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Immune Response Virus Vaccine Research 52

PerkinElmer

JUNE 23, 2020

However, management of the virus continues to bewilder the world’s finest researchers and clinicians… and our traditional standards of pharmaceutical regulation have necessitated adaptation. The post Pharma’s Adaptive Agility and COVID-19 first appeared on PerkinElmer Blog.

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Clinical Trials Pharmaceuticals Trials Virus 52

PerkinElmer

JANUARY 21, 2021

It is particularly prevalent on cells that line the air sacs in lungs, hence the rampaging respiratory effects we’ve come to associate with the virus. The post Repurpose, Reuse, Rediscover Drugs for COVID-19 Treatments first appeared on PerkinElmer Blog. It influences blood flow and is involved in many organs.

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Treatment Small Molecule Drugs Virus 52

The Premier Consulting Blog

MARCH 7, 2024

For gene therapy vectors, this testing encompasses production cell lines, master and working cell banks (MCB, WCB), and virus banks. Depending on the gene therapy vector, microbial systems may be employed to produce vector DNA (such as in adeno associated virus (AAV)), in which case there may be bacterial cell banks and plasmid banks.

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Production Therapies DNA Virus 52

FDA Law Blog: Biosimilars

OCTOBER 24, 2023

To learn more about our experience with the eSTAR for 510(k)s, check out our previous blogs ( here , here ). Note, however, that there is a virus scanning and technical screening process that will still happen. Make sure you submit your application using the most up-to-date version of eSTAR, as FDA frequently updates eSTAR templates.

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FDA Virus Regulations Production 52

New Drug Approvals

AUGUST 22, 2023

1951476-79-1 Hepatitis B virus (HBV) is an infectious disease that targets the liver resulting in either an acute infection, with symptoms arising in 45 to 160 days, or a chronic infection, which 350 million people worldwide are affected by. EIDD-2173; also known as ATI-2173 Fosclevudine alafenamide Phase 2 Molecular Weight 529.45

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RNA DNA Virus Treatment 52

NIH Director's Blog: Drug Development

FEBRUARY 1, 2022

The ACE2 drug candidate, which is soluble and degrades in the body, also proved ineffective in neutralizing the virus. In the lab, it also appeared to neutralize the virus as well as monoclonal antibodies used to treat COVID-19. In fact, the decoy bound just as well, if not better, to new variants compared to the original virus.

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Virus Clinical Trials Engineering Treatment 52

Alta Sciences

JANUARY 11, 2024

There are three primary vectors employed in gene therapy: adeno-associated virus (AAV), adenovirus, or lentivirus vectors. Image Blog-Thumbnail_The-Altascientist-issue-36.jpg Some therapies are considered both cell and gene therapies, as they alter genes in specific types of cells.

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Therapies Immune Response Disease Virus 52

FDA Law Blog: Drug Discovery

DECEMBER 7, 2022

At the same time, it is understandably important to be able to measure and characterize a treatment’s effect over time. However, with this most recent approval, FDA did not leave the question of durability as something to be answered postapproval, which signals to us that this issue looms large in FDA’s preapproval regulation of gene therapies.

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Therapies FDA FDA Approval Treatment 119