PLOS: DNA Science

SEPTEMBER 7, 2023

As genetics morphed into genomics, artificial intelligence stepped in, layering the combinatorial information of comparative genomics onto DNA sequences. Train an algorithm on the DNA sequences of a known disease-causing gene, then search for identical or highly similar sequences in cells from other individuals to assist diagnosis.

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PLOS: DNA Science

NOVEMBER 16, 2023

Here at DNA Scienc e a few years ago, I shared The Peaceable Genomes of Pumpkins. The situation is a little like reading a book review or CliffsNotes (yes, they still exist) to get the main plot points (QTLs) compared to reading the entire book (the genome sequence). But I’m still a biologist at heart.

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PLOS: DNA Science

OCTOBER 12, 2023

In the final chapter of my 2012 book The Forever Fix: Gene Therapy and the Boy Who Saved It , I predicted that the technology would soon expand well beyond the rare disease world. million DNA bases. The DMD gene therapy delivers a shortened version of the dystrophin gene, just 4,558 DNA bases. appeared first on DNA Science.

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sptlabtech

JUNE 9, 2023

Book your tailored demo This further translates to reduced amount of plastic waste. Do you want to learn how firefly can work for you? Our team of scientists and engineers are always on hand to listen and understand your current challenges, so we can provide a demonstration tailored to your specific needs.

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Laboratories Molecular Biology DNA Engineering 89

PLOS: DNA Science

JANUARY 4, 2024

” CRISPRs are short DNA sequences, peppered with repeats, that latch onto DNA-cutting enzymes, commandeering and directing them to snip certain parts of a chromosome. Unlike gene therapy as originally-envisioned since the 1950s, which adds a functioning copy of a gene, CRISPR can add, remove, or replace a DNA sequence.

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PLOS: DNA Science

MAY 4, 2023

Over time, the mineralized microbes of tooth tartar come to comprise a mouthful of tiny fossils, including snippets of degraded bacterial DNA. ” But long DNA molecules fray as they’re copied as bacteria reproduce, from ancient times leaving pieces too small to match entries in DNA databases from modern species.

DNA 52

DNA Production RNA Science 52

Drug Target Review

MAY 24, 2024

2 AlphaFold 3 has been built to model DNA, RNA and smaller molecules (ligands). Google DeepMind’s new AI can model DNA, RNA, and ‘all life’s molecules’. He has published several papers and two books and has twelve issued patents. There are several technologies and specific tools being rolled out in this area. Alphafold 3.0:

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RNA DNA Bioinformatics Science 59

PLOS: DNA Science

JUNE 1, 2023

My now decade-old book The Forever Fix: Gene Therapy and the Boy who Saved It , told the stories of children who had received one-time deliveries of working copies of genes, to compensate for their mutations. This DNA Science post from 2018 traces the history of the efforts. RDEB is inherited from two carrier parents.

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Codon

JULY 27, 2023

They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. And that’s how I learned that there are published books that contain entire chromosome sequences. A real book that contains the full sequence of human chromosome 21. From Ling B et al.

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Codon

JULY 27, 2023

They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. And that’s how I learned that there are published books that contain entire chromosome sequences. A real book that contains the full sequence of human chromosome 21. From Ling B et al.

Therapies 52

Therapies RNA DNA Engineering 52

PLOS: DNA Science

SEPTEMBER 21, 2023

The information on the poster inspired a “Case Study and Research Results” question in my book’s chapter on Human Ancestry and Evolution: “A genome from a person of aborigine ancestry was sequenced from a 100-year-old museum sample. From people who have died?”

DNA 52

DNA Science Medical Schools Government 52

Codon

MAY 30, 2023

This week: A way to measure a transgene’s expression in the brain using ultrasound, a DNA sequencing method that uses 1000x less reagents, and base editors get even smaller. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. so this Digest will be published more irregularly.

DNA 52

DNA RNA Engineering Vaccine 52

Codon

MAY 30, 2023

This week: A way to measure a transgene’s expression in the brain using ultrasound, a DNA sequencing method that uses 1000x less reagents, and base editors get even smaller. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. so this Digest will be published more irregularly.

DNA 52

DNA RNA Engineering Vaccine 52

Codon

OCTOBER 27, 2024

The Most Deadly Infectious Disease “Each successive episode of bleeding left him weaker than before,” wrote Mary Doria Russell of Doc Holliday, the gunslinging gambler, in her eponymous book, Doc. Published in 1971, the book contains unsparing descriptions of Holliday’s deteriorating medical condition.

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Immune Response Doctors Disease Laboratories 77

Codon

JULY 11, 2023

That’s because proteins are made, in the laboratory, using synthetic DNA and cells; and DNA is expensive. Our machine would make proteins without using any DNA or cells. All cells make proteins in two steps: DNA is transcribed into messenger RNA, which is then translated into protein.

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Codon

JULY 11, 2023

That’s because proteins are made, in the laboratory, using synthetic DNA and cells; and DNA is expensive. Our machine would make proteins without using any DNA or cells. All cells make proteins in two steps: DNA is transcribed into messenger RNA, which is then translated into protein.

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RNA DNA Engineering Laboratories 52

Codon

FEBRUARY 20, 2024

I first encountered Von Baer’s thought experiment in Richard Fisher’s book, The Long View. Thanks to decades of progress in molecular sequencing technologies, it is simple to read out the order of nucleotides in a DNA sequence, for example, or to quantify messenger RNAs as they are made by a cell.

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PLOS: DNA Science

OCTOBER 5, 2023

After treatment, we sent notes, books, flowers, gift cards. We watched the special Bandersnatch episode of Black Mirror and played the game of choosing a story path and alternate endings, which inspired my DNA Science post from exactly a year ago comparing the game to a journey with breast cancer.

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PLOS: DNA Science

JUNE 22, 2023

A “DNA damage checkpoint” rests the cell cycle while special proteins repair damaged DNA. She chronicled her journey in Glamour and in My So-Called Normal Life, a book published in 2005. The post How Targeted Cancer Drugs Disrupt the Cell Cycle appeared first on DNA Science. Blood cancer.

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Drugs Small Molecule DNA Bioethics 52

Codon

DECEMBER 17, 2023

Recombinant DNA technologies were invented in the 1970s. Today we’re launching Asimov Press , a new publishing venture modeled on Stripe Press , that will produce a newsletter, magazine, and books that feature writing about biology. Book projects will launch in 2024. Newsletters and magazines will be free to read.

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Engineering Molecular Biology Doctors DNA 52

The Pharma Data

DECEMBER 2, 2020

are acting as joint book-running managers. Twist may also use a portion of the net proceeds to in-license, acquire or invest in complementary businesses or products. Morgan Securities LLC, Goldman Sachs & Co. LLC, Cowen and Company, LLC and Evercore Group L.L.C. Baird & Co. Incorporated is acting as lead manager.

DNA 52

DNA Licensing Licensing Pharmaceuticals 52

Codon

MARCH 12, 2023

“The recombinant DNA breakthrough has provided us with a new and powerful approach to the questions that have intrigued and plagued man for centuries. The central dogma is often depicted as DNA→RNA→protein, but it’s much more: A biophysical marvel inside the smallest of vessels. Biology is a Burrito. 6 of 31.

DNA 52

DNA Engineering Therapies RNA 52

The Open Targets Blog

APRIL 25, 2023

Since the operations at ‘Station X’ became declassified, the wartime work at Bletchley Park including notable individuals such as Alan Turing has become well known in popular films and books. Only later were the first computers established to automate intelligence gathering.

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DNA Government Engineering Laboratories 52

The Pharma Data

JANUARY 20, 2021

Nasdaq: INO), a biotechnology company focused on bringing to market precisely designed DNA medicines to treat and protect people from infectious diseases, including COVID-19, cancer and HPV-associated diseases, today announced the pricing of an underwritten public offering of 17,700,000 shares of its common stock at a public offering price of $8.50

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Codon

APRIL 30, 2023

Yeast die for two reasons: Either their nucleolus (where the DNA is kept) degrades and dies, or their mitochondria whimpers out and they stop making energy. The vaccine printer can make lots of different types of vaccines, including protein, DNA, and mRNA ones, but I’m sure this is all quite expensive right now. From Zhang et al.

Vaccine 52

Vaccine DNA Engineering RNA 52

Codon

APRIL 30, 2023

Yeast die for two reasons: Either their nucleolus (where the DNA is kept) degrades and dies, or their mitochondria whimpers out and they stop making energy. The vaccine printer can make lots of different types of vaccines, including protein, DNA, and mRNA ones, but I’m sure this is all quite expensive right now. From Zhang et al.

Vaccine 52

Vaccine DNA Engineering RNA 52

The Pharma Data

JANUARY 24, 2021

He has published more than 200 articles and book chapters. OraSure, together with its wholly-owned subsidiaries, DNA Genotek, Diversigen, and Novosanis, provides its customers with end-to-end solutions that encompass tools, services and diagnostics. About Diversigen Inc. Diversigen, Inc. Diversigen and CoreBiome, Inc.

Research 40

Research Bioinformatics Laboratories International 40

PLOS: DNA Science

AUGUST 10, 2023

It is an unforgettable book. The post The Covenant of Water by Abraham Verghese: A Geneticist’s Review appeared first on DNA Science. I urge them to stick with it, for this soaring narrative conveys the terror of inherited disease in a way that my own non-fiction – textbooks and articles – never could.

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Disease DNA Doctors Hospitals 98

LifeSciVC

FEBRUARY 16, 2024

In his book The Innovators , Walter Isaacson notes that game-changing tech companies (Intel, Qualcomm, etc.), Choosing the wrong candidate from an artificially limited pool is ultimately disruptive and risks imprinting the wrong habits in the company’s DNA. Pushing for a CEO too early may mean constraining your options.

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Vial

FEBRUARY 19, 2024

Also, payloads that are permeable payloads and specifically microtubule inhibitors or DNA alkylators or chemo. I don’t know if you’ve read that book, but it’s a very important book, where you always do your best. We always try to stick with The Four Agreements. You speak impeccably.

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Small Molecule Therapies Treatment Science 52

The Pharma Data

MAY 14, 2021

The Key To Your Fat Loss (And Your Results) Is Unlocking Your Inner Athlete Which Is Already Built Into Your DNA! Is Built Right Into Your DNA: And This Program Wakes It Up! Instead…they were performing what we call “Functional Movements” or movements that are built right into our DNA. He called it Functional Training.

DNA 52

DNA Production Vaccine Science 52

KIF1A

AUGUST 20, 2024

” And while the Rosens have been open books when asked about their experiences, we’ve also always cautioned that the study is still underway. We’ve been able to discuss the guiding philosophy and design, the steps of research, and more recently the potential amenability in our wider community.

Science 52

Science Treatment Therapies Small Molecule 52

PLOS: DNA Science

JULY 11, 2024

In the classic film Jurassic Park (JP) from 1993, disasters unfurl at a theme park populated with dinosaurs cloned from reptile DNA in mosquitoes fossilized in amber, with modern frog DNA filling in gaps. The animals were cloned from DNA in bits of preserved ear bones, and doctored a bit. percent of our DNA sequence with chimps?

DNA 52

DNA Science Doctors Engineering 52

Codon

FEBRUARY 28, 2023

1 One rarely pauses to ponder how so much DNA — let alone sugar, proteins, and everything else — can fit inside such a small vessel. The graphic is from Ron Milo and Rob Phillips ’ book, Cell Biology by the Numbers , but the calculations originally appeared in the textbook, “ Physiology of the Bacterial Cell.”

RNA 52

RNA DNA Cell Biology Small Molecule 52

Codon

APRIL 2, 2024

in physics at Princeton University, he had a remarkable idea: What if it were possible to build a circuit out of DNA, rather than electronics, and use it to “program” a living cell? In 1997, as Michael Elowitz was studying for a Ph.D.

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RNA Engineering Molecular Biology Synthetic Chemistry 55

PLOS: DNA Science

APRIL 27, 2023

” The subtext: Textbooks shouldn’t use only or mostly photos of white people, and interpreting DNA test results shouldn’t be based on research done mostly on white people. ” The flaggers must not have seen the film or read the book of The Time Machine. ” I thought I’d been doing a decent job.

DNA 52

DNA Disease Science Drug Development 52

PLOS: DNA Science

DECEMBER 21, 2023

A few weeks ago, I noticed a surprising metric when posting my weekly DNA Science blog – at year’s end, I’d hit #500! The Birth of DNA Science When St. Martin’s Press was about to publish my book about gene therapy in 2012, my agent urged me to start blogging. We renamed it DNA Science.

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