Codon

MARCH 12, 2023

“The recombinant DNA breakthrough has provided us with a new and powerful approach to the questions that have intrigued and plagued man for centuries. The central dogma is often depicted as DNA→RNA→protein, but it’s much more: A biophysical marvel inside the smallest of vessels. Biology is a Burrito. 6 of 31.

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Codon

JULY 11, 2023

Scientists at the Institute for Protein Design have crafted proteins that self-assemble into nanomaterials or that can be used as vaccines for the flu and HIV. That’s because proteins are made, in the laboratory, using synthetic DNA and cells; and DNA is expensive. Some catalyze reactions 30 million times per second.

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Codon

DECEMBER 17, 2023

Recombinant DNA technologies were invented in the 1970s. Today we’re launching Asimov Press , a new publishing venture modeled on Stripe Press , that will produce a newsletter, magazine, and books that feature writing about biology. We’re particularly fond of Why We Didn’t Get a Malaria Vaccine Sooner.

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Codon

APRIL 16, 2023

Short DNA strands were discovered that can specifically and tightly bind to zinc and cadmium ions. Perhaps there is now a way to use DNA to extract metals: You could fuse the DNA strands to an antibody, coat them onto electronics, and then use a column to isolate the DNA:metal compounds? coli DNA using a Retro-Cascorder.

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Codon

MAY 30, 2023

This week: A way to measure a transgene’s expression in the brain using ultrasound, a DNA sequencing method that uses 1000x less reagents, and base editors get even smaller. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. so this Digest will be published more irregularly.

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DNA RNA Engineering Vaccine 52

Codon

MAY 30, 2023

This week: A way to measure a transgene’s expression in the brain using ultrasound, a DNA sequencing method that uses 1000x less reagents, and base editors get even smaller. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. so this Digest will be published more irregularly.

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DNA RNA Engineering Vaccine 52

Codon

JANUARY 2, 2025

Our second book is now available for pre-order. Embracing the book’s technology theme, we did something very special: With the help of three companies — CATALOG, Imagene, and Plasmidsaurus — we’ve encoded a complete copy of the book into DNA, thus merging bits with atoms.

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PLOS: DNA Science

FEBRUARY 20, 2025

With infectious diseases on the rise, she asked me to repost CDC’s Adult Vaccine Assessment Tool. could head Health and Human Services, and friends asking me which vaccines they needed to update or get for the first time. Which Vaccines Require Boosters? But which other vaccines should my daughter and her cohort get?

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PLOS: DNA Science

DECEMBER 21, 2023

A few weeks ago, I noticed a surprising metric when posting my weekly DNA Science blog – at year’s end, I’d hit #500! The Birth of DNA Science When St. Martin’s Press was about to publish my book about gene therapy in 2012, my agent urged me to start blogging. We renamed it DNA Science.

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PLOS: DNA Science

FEBRUARY 27, 2025

DNA Science has covered Rare Disease Day for years – links are at the end of this post. Combining genetic material – which is possible because all organisms have DNA and their cells use the same genetic code – was novel and scary. Recombinant DNA technology has become mainstream.

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Disease DNA FDA Therapies 74

Codon

NOVEMBER 1, 2024

Such models will, in turn, make it much easier to invent the sorts of platform tools that Amodei asserts “drive >50% of progress in biology,” such as CRISPR and mRNA vaccines, because the creation of these tools ultimately derive from a deeper understanding of how cells work. If we could get E.

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Codon

AUGUST 10, 2023

Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link Next-Generation DNA Sequencing Methods , by Mardis E.R. Link DNA synthesis technologies to close the gene writing gap , by Hoose et al.

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Codon

OCTOBER 27, 2024

The second part — focused on vaccines and medicines — will be published next Sunday, concluding Issue 04 of Asimov Press. The Most Deadly Infectious Disease “Each successive episode of bleeding left him weaker than before,” wrote Mary Doria Russell of Doc Holliday, the gunslinging gambler, in her eponymous book, Doc.

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Immune Response Doctors Disease Laboratories 91

Codon

MARCH 16, 2025

Today, decades after the invention of DNA sequencing, it is easy to take the accessibility of genomic data for granted. But in the early 1990s, when Guilford’s group began collecting blood and tumor samples from the MacLeods, DNA sequencing technology was still costly and unwieldy. Cite: Jennifer Remmel.

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PLOS: DNA Science

JULY 25, 2024

The book has a conversational tone, an easy read even for the science-shy. Yet the book is also global in scope. “The Search for an HIV Vaccine” chapter clearly explains how vaccines protect, as well as how progress in scientific inquiry slows when we do not know what we do not know.

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