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Mirati Therapeutics Announces Pricing Of Public Offering Of Common Stock – Oct 28, 2020

The Pharma Data

are acting as joint book-running managers in the offering. are also acting as book-running managers in the offering. Sitravatinib is an investigational spectrum-selective inhibitor of receptor tyrosine kinases (RTK) designed to enhance immune responses through the inhibition of immunosuppressive signaling.

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Scientific workflow for hypothesis testing in drug discovery: Part 3 of 3

Drug Target Review

The KEGG Pathway database provides insights into metabolic pathways, genetic interactions and disease mechanisms, which are crucial for understanding how a dataset can inform our understanding of complex biological phenomena such as signal transduction, cell proliferation, or immune responses.

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Replimune Announces Pricing of Upsized Public Offering – Oct 22, 2020

The Pharma Data

are acting as joint book-running managers for the offering. Replimune is developing novel, proprietary therapeutics intended to improve the direct cancer-killing effects of selective virus replication and the potency of the immune response to the tumor antigens released. Wedbush Securities Inc.

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Is Recent Gene Therapy Setback for Duchenne Muscular Dystrophy (DMD) Déjà vu All Over Again?

PLOS: DNA Science

In the final chapter of my 2012 book The Forever Fix: Gene Therapy and the Boy Who Saved It , I predicted that the technology would soon expand well beyond the rare disease world. Can they deliver healing genes without triggering an overactive immune response? An immune response is two-tiered. I was overoptimistic.

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CRISPR Tackles Diverse Single-Gene Conditions

PLOS: DNA Science

The microbes deploy them to dismantle the genetic material of infecting viruses, a little like an immune response. My book The Forever Fix: Gene Therapy and the Boy Who Saved It , describes early gene therapy attempts, beginning with the first clinical trial in 1990.

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INOVIO Announces Pricing of Public Offering of Common Stock – Jan 21, 2021

The Pharma Data

BofA Securities, Jefferies and Cantor are acting as joint book-running managers for the offering. INOVIO is the first and only company to have clinically demonstrated that a DNA medicine can be delivered directly into cells in the body via a proprietary smart device to produce a robust and tolerable immune response.

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Synthetic Origins

Codon

I was reading a lot of molecular biology papers about different systems, especially circadian clocks, and also a book called Biological Feedback , by Thomas and D’Ari, that sketched out really simple models for different kinds of feedback circuits. Another one is immunogenicity.

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